Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

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Inhibitor Brutto MW Action Reference Reference 2
SGK1-Sanofi-308-R   C23H23FN6O4S 498.53 SGK1
SGK1-Sanofi-308-S   C23H23FN6O4S 498.53 SGK1
SGK1-Sanofi-ex.290-R   C24H25ClN6O5S 545.01 SGK1
SGK1-Sanofi-ex.290-S   C24H25ClN6O5S 545.01 SGK1
Simotinib   C25H26ClFN4O4 500.90 EGFR
Sirolimus   C51H79NO13 914.20 p70S6K, mTOR Powell D.J. (2003) Mol. Cell Biol. 23 7794 Braun W. (1995) FASEB J. 9 63
SL-327 (MEK1-2 Inhibitor)   C16H12F3N3S 335.40 MEK1, MEK2 Hetman M. (2002) J. Biol. Chem. 277 49577 Ohno M. (2001) Nat. Neurosci. 4 1238
SL0101-1   C25H24O12 516.46 RSK Smith (2005) Cancer Res. 65 1027 Goden Sayeski (2006) Am. J. Cell. Physiol. 291 1308
Sodium salicylate   HOC6H4COONa 160.10 p38 Schwenger P. (1998) Mol Cell Biol. Jan 18(1) 78-84
Sodium valproate   C8H15NaO2 166.19 Histone deacetylase Phiel (2001) J.Biol.Chem. 276 36734 Kostrouchova (2007) Folia Biologica 53 37
Sorafenib   C21H16ClF3N4O3 464.80 Raf, Multiple Tyrosine Kinases Targeted Lyons J.F. (2001) Endocrine Related Cancer 8 3 219-225 Wilhelm S.M. (2004) Cancer Res. 64(19) 7099-109
Sotorasib   C30H30F2N6O3 560.60
SP600125 (JNK Inhibitor II, SAPK Inhibitor II)   C14H8N2O 220.20 JNK Shin M. Boyd Y.D. (2002) Biochim. Biophys. Acta 1589 311 Bennett B.L. (2001) Proc. Natl. Acad. Sci. USA 98 13681
Sphingosine Kinase Inhibitor (SKI II)   C15H11ClN2OS 339.20 SphK1 French (2003) Cancer Res. 63 5962. French (2006) J.Pharmacol.Exp.Ther. 318 596
SRC Inhibitor 1   C22H19N3O3 373.40 Src Tian G. (2001) Biochemistry 40 7084
SRT 1720   C27H24F3N7O3S 583.59 SIRT1 Milne J.C. Lambert P.D. Schenk S. (2007) Nature 450 712-716
Staurosporine C28H26N4O3 466.54 Broad spectrum Boix J. (1997) Neuropharmacology 36 811-821 Wiesner D.A. and Dawson G. (1996) J. Neurochem. 66 1418-1425
STO 609   C19H10N2O3 • CH3CO2H 374.40 CaMKK Levine Y. (2007) J. Biol. Chem. 282 20351 Tokumitsu H. (2003) J. Biol. Chem. 278 10908
STOCK1S-50699   C29H31IN2S2 598.60 WNK Mori T. (2013) Biochem J. 1 455(3) 339-45
STOCK2S-26016   C20H19N3O2 333.39 WNK Mori T. (2013) Biochem J. 1 455(3) 339-45
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