| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| Sorafenib | C21H16ClF3N4O3 | 464.80 | 284461-73-0 | 216239 | Raf, Multiple Tyrosine Kinases Targeted | Lyons J.F. (2001) Endocrine Related Cancer 8 3 219-225 | Wilhelm S.M. (2004) Cancer Res. 64(19) 7099-109 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| AMPK | 89 | 4 |
| Aurora B | 15 | 1 |
| Aurora C | 34 | 1 |
| BRSK2 | 80 | 2 |
| CAMK1 | 53 | 3 |
| CAMKK alpha | 97 | 1 |
| CAMKK beta | 88 | 3 |
| CDK2-Cyclin A | 80 | 7 |
| CHK1 | 89 | 5 |
| CHK2 | 99 | 0 |
| CK1 delta | 99 | 3 |
| CK2 | 95 | 3 |
| CSK | 63 | 3 |
| DYRK1A | 82 | 8 |
| DYRK2 | 81 | 4 |
| DYRK3 | 47 | 8 |
| EF2K | 99 | 1 |
| ERK1 | 92 | 7 |
| ERK2 | 91 | 3 |
| ERK8 |
7
|
2 |
| GSK3 beta | 64 | 1 |
| HIPK2 | 14 | 1 |
| HIPK3 | 21 | 2 |
| IKK beta | 94 | 0 |
| JNK1 | 83 | 5 |
| JNK2 | 65 | 4 |
| JNK3 | 101 | 4 |
| Lck | 27 | 0 |
| MAPKAP-K2 | 104 | 5 |
| MAPKAP-K3 | 92 | 1 |
| MARK3 | 83 | 0 |
| MELK | 56 | 5 |
| MKK1 | 74 | 3 |
| MNK1 | 67 | 5 |
| MNK2 | 40 | 2 |
| MSK1 | 84 | 2 |
| MST2 | 91 | 4 |
| NEK2a | 92 | 5 |
| NEK6 | 92 | 9 |
| NEK7 | 96 | 4 |
| p38 alpha MAPK | 14 | 2 |
| p38 beta MAPK | 22 | 4 |
| p38 delta MAPK | 61 | 4 |
| p38 gamma MAPK | 68 | 1 |
| PAK4 | 89 | 4 |
| PAK5 | 89 | 3 |
| PAK6 | 94 | 2 |
| PDK1 | 82 | 2 |
| PHK | 90 | 2 |
| PIM1 | 72 | 2 |
| PIM2 | 98 | 1 |
| PIM3 | 65 | 8 |
| PKA | 72 | 3 |
| PKB alpha | 94 | 1 |
| PKB beta | 83 | 1 |
| PKC alpha | 87 | 1 |
| PKC zeta | 92 | 4 |
| PKD1 | 90 | 1 |
| PLK1 | 93 | 1 |
| PRAK | 84 | 4 |
| PRK2 | 79 | 1 |
| ROCK 2 | 71 | 8 |
| RSK1 | 41 | 4 |
| RSK2 | 54 | 3 |
| S6K1 | 76 | 4 |
| SGK1 | 90 | 3 |
| SmMLCK | 84 | 1 |
| Src | 44 | 1 |
| SRPK1 | 88 | 5 |