Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
Roscovitine   C19H26N6O 354.50 CDK De Azevedo W.F. (1997) Eur. J. Biochem. 243 518 Meijer L. (1997) Eur. J. Biochem. 243 527
Rottlerin   C30H28O8 516.50 PKC Villalba M. (1999) J. Immunol. 163 5813 Gschwendt M. (1994) Biochem. Biophys. Res. Commun. 199 93
Ruxolitinib   C17H18N6 306.37 JAKs Lawrence J Wilson (2010) Expert Opinion on Therapeutic Patents May 20(5) 609-6…
Saracatinib (AZD0530)   C27H32ClN5O5 542.03 Src H Laurent (2006) J. Med. Chem. 49(22) 6465-6488
Savolitinib   C17H15N9 345.40 c-MET
SB-202190   C20H14FN3O 331.30 p38 MAPK Davies S.P. (2000) Biochem. J. 351 95 Ajizian S.J. (1999) J. Infect. Dis. 179 939
SB-203580   C21H16N3OSF 377.40 p38 MAPK Powell D.J. (2003) Mol. Cell Biol. 23 7794 Davies S.P. (2000) Biochem. J. 351 95
SB-216763   C19H12Cl2N2O2 371.22 GSK3 Coghlan (2000) Chem.Biol. 7 793 Liang (2006) J.Biol.Chem. 282 3904
SB-415286   C16H10ClN3O5 359.73 GSK3 Coghlan (2000) Chem.Biol. 7 793 Cross (2001) J.Neurochem. 77 94
SB-431542   C22H16N4O3 · xH2O 384.39 ALK Inman et al (2002) Mol.Pharmacol. 62 65
SB-505124   C20H21N3O2 · xHCl · yH2O 335.40 ALK Byfield (2004) Mol.Pharmacol. 65 744
SB-590885 C27H27N5O2 453.54 B-Raf King (2006) Cancer Res. 66 11100
SB-747651A C16H22N8O 342.40 Naqvi (2012) Biochem. J. 441 (347–357)
SC514 ( IKK-2 Inhibitor)   C9H8N2OS2 224.30 IKK2 Baxter A. (2004) Bioorg. Med. Chem. Lett. 14 2817 Kishore N. (2003) J. Biol. Chem. 278 32861
Selpercatinib   C29H31N7O3 525.60 RET fusions
Selumetinib   C17H15BrClFN4O3 457.70 MEK1/2
SGK-Sanofi-14i   C18H15ClN6O3S SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78
SGK1-Sanofi-14g   C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78
SGK1-Sanofi-14h   C17H12Cl2N6O2S 435.29 SGK Halland, N (2015) ACS Medicinal Chemistry Letters , 6,73-78
SGK1-Sanofi-14n   C17H12CIFN6O2S 418.83 SGK Halland, N (2015) ACS Medicinal Chemistry Letters 6 73-78