Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
PRT062607   C19H23N9O 393.45 SYK Spurgeon S.E. (2013) J. Pharmacol Exp Ther. 2013 Feb. 344(2) 378-387
PS-1145   C17H11ClN4O 322.75 IKK Castro A.C. (2003) Bioorg. Med. Chem. Lett. 13 2419-2422.
Purvalanol A   C19H25ClN6O 388.90 cyclin-dependent kinases Gray N.S. (1998) Science 281 533
Purvalanol B   C20H25ClN6O3 432.90 CDK
Pyrotinib   C32H31ClN6O3 583.10 EGFR; HER2/4
QNZ   C22H20N4O 356.40 NF-κB
Quercetagetin C15H10O8 318.30 PIM1 Holder S. (2007) Mol. Cancer Ther. 6 163
Quizartinib   C29H32N6O4S 560.67
R-406   C23H24FN5O5 469.46 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008
Radotinib   C27H21F3N8O Bcr-Ab1, PDGFR
Ramucirumab   KDR (VEGFR2)
Regorafenib   C21H15ClF4N4O3 VEGFR2, TIE2, Others, PIKs
Resveratrol   C14H12O3 228.20 cyclo-oxygenase 1 Lin H.Y. (2002) J. Urol. 168 748 Klabunde T. (2000) Nat. Struct. Biol. 7 312
Ribociclib   C23H30N8O 434.50 CDK4/6
Rigel TRAF6 Inhibitor   C16H12ClF4N5O3S 465.81 TRAF6
Ripasudil C15H18FN3O2S 323.40 ROCK1/2
Ripretinib   C24H21BrFN5O2 510.40 KIT; PDGFRA incl mutants
Ritlecitinib C15H19N5O
RO-31-8220   C25H23N5O2S • CH4O3S 553.70 PKC Trapp J. (2006) J. Med. Chem. 49 7307-16 Powell D.J. (2003) Mol. Cell Biol. 23 7794
RO-3306   C₁₈H₁₃N₃OS₂ 351.50 Cdk1 Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660