Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
PD 184352 (CI-1040)   C17H14ClF2IN2O2 478.66 MEK1, Yes1, ERK1 Mayes PA. (2013) Int J Cancer. E149-57
Peficitinib   C18H22N4O2 326.40 JAK
Pemigatinib   C24H27F2N5O4 487.50 FGFR
Pertuzumab   ERBB2
Pexidartinib   C20H15ClF3N5 417.80 CSF1R; c-KIT; FLT3
PF3644022   C21H18N4OS 374.46 MAPKAPK2 Mourey (2010) J.Pharmacol.Exp.Ther. 333 797
PF4708671 C19H21F3N6 390.41 S6K1 Pearce (2010) Biochem.J. 431 245
PI-103   C19H16N4O3 348.36 PI3K Samuels Y. (2004) Science 304 554
Piceatannol   C14H12O4 244.20 PKA, SYK Wang B.H. (1998) Planta Med. 64 195 Keely P.J. and Parise L.V. (1996) J. Biol. Chem. 271 26668
Pirfenidone   C12H11NO 185.23 Antifibrotic agent, SAPK Kehrer and Margolin (1997) Toxicol. Lett. 90 125 Iyer (1999) J.Pharmacol.Exp.Ther. 289 211
Pirtobrutinib C22H21F4N5O3 479.40
PKR Inhibitor   C13H8N4OS 268.30 PKR Ingrand S (2007) FEBS Lett. 581(23):4473-8
PLX 4720 (Raf Kinase Inhibitor V)   C17H14ClF2N3O3S 413.83 B-Raf Tsai J. (2008) Proc Natl Acad Sci USA. 3041-6
Ponatinib   C29H27F3N6O SRC, Ab1
PP1   C16H19N5 281.36 Src Hanke (1996) J.Biol.Chem. 271 695 Liu (1999) Chem.Biol. 6 671
PP2   C15H16ClN5 301.77 Src Kirihara T. (2013) Exp Eye Res. S0014
PP242   C16H16N6O 308.30 mTOR Feldman ME (2009) PLoS Biol 7(2)
PP3 C11H9N5 211.22 Src Hou (2007) Neurosci Lett 420 235
Pralsetinib   C27H32FN9O2 533.60 RET
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639