Protein transformations that change lives

Inhibitor | Sphingosine Kinase Inhibitor (SKI II)

Compound name	Brutto	MW	CAS	PubChem CID	Action	Reference	Reference
Sphingosine Kinase Inhibitor (SKI II)	C₁₅H₁₁ClN₂OS	339.20	1177741-83-1	16760659	SphK1	French (2003) Cancer Res. 63 5962.	French (2006) J.Pharmacol.Exp.Ther. 318 596

Screen Conc: 1.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	101	1
AMPK	93	1
ASK1	90	10
Aurora A	107	6
Aurora B	93	4
BRK	89	7
BRSK1	83	15
BRSK2	91	5
BTK	102	13
CAMK1	94	6
CAMKK beta	99	1
CDK2-Cyclin A	100	5
CHK1	113	16
CHK2	91	4
CK1 delta	105	15
CK2	92	11
CLK2	94	4
CSK	65	1
DAPK1	109	6
DYRK1A	81	3
DYRK2	99	2
DYRK3	100	0
EF2K	92	6
EPH-A2	110	16
EPH-A4	98	3
EPH-B1	118	6
EPH-B2	117	19
EPH-B3	105	10
EPH-B4	98	13
ERK1	106	16
ERK2	93	1
ERK8	95	3
FGF-R1	95	16
GCK	90	20
GSK3 beta	115	1
HER4	84	5
HIPK1	112	3
HIPK2	91	4
HIPK3	101	12
IGF-1R	102	5
IKK beta	94	8
IKK epsilon	103	18
IR	80	4
IRAK4	79	2
IRR	109	29
JAK2	113	14
JNK1	91	11
JNK2	90	2
JNK3	82	4
Lck	88	0
LKB1	95	3
MAPKAP-K2	106	5
MAPKAP-K3	91	2
MARK1	97	4
MARK2	93	8
MARK3	88	5
MARK4	85	7
MEKK1	96	7
MELK	76	2
MINK1	88	9
MKK1	94	1
MKK2	92	15
MKK6	93	14
MLK1	100	35
MLK3	84	2
MNK1	91	3
MNK2	99	10
MPSK1	88	11
MSK1	108	17
MST2	90	6
MST4	107	24
NEK2a	103	14
NEK6	101	5
NUAK1	85	10
p38 alpha MAPK	83	10
p38 beta MAPK	78	0
p38 delta MAPK	113	9
p38 gamma MAPK	111	23
PAK2	97	12
PAK4	91	11
PAK5	98	3
PAK6	83	3
PDK1	86	0
PHK	84	4
PIM1	67	0
PIM2	93	11
PIM3	52	13
PKA	96	14
PKB alpha	110	6
PKB beta	82	8
PKC alpha	106	1
PKC gamma	74	4
PKC zeta	103	1
PKD1	89	3
PLK1	106	0
PRAK	108	18
PRK2	94	11
RIPK2	97	4
ROCK 2	77	9
RSK1	114	0
RSK2	104	4
S6K1	114	8
SGK1	107	8
SmMLCK	85	4
Src	98	12
SRPK1	101	2
STK33	105	16
SYK	96	19
TAK1	97	1
TAO1	109	12
TBK1	98	12
TIE2	108	2
TrkA	105	15
TTK	95	7
VEGFR1	78	5
YES1	81	5
ZAP70	108	3

Screen Conc: 10.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	75	5
AMPK	89	7
ASK1	83	1
Aurora A	59	5
Aurora B	89	4
BRK	73	3
BRSK1	73	11
BRSK2	80	4
BTK	80	12
CAMK1	22	1
CAMKK beta	84	6
CDK2-Cyclin A	94	12
CHK1	131	24
CHK2	50	11
CK1 delta	109	10
CK2	84	13
CLK2	75	0
CSK	75	11
DAPK1	89	16
DYRK1A	54	11
DYRK2	101	0
DYRK3	82	2
EF2K	85	6
EPH-A2	80	6
EPH-A4	59	2
EPH-B1	86	14
EPH-B2	92	5
EPH-B3	117	4
EPH-B4	81	8
ERK1	86	23
ERK2	97	1
ERK8	59	1
FGF-R1	84	2
GCK	38	8
GSK3 beta	101	4
HER4	45	13
HIPK1	90	16
HIPK2	62	2
HIPK3	86	20
IGF-1R	89	10
IKK beta	94	0
IKK epsilon	84	3
IR	88	18
IRAK4	86	3
IRR	76	22
JAK2	93	8
JNK1	84	4
JNK2	84	17
JNK3	88	3
Lck	84	3
LKB1	81	4
MAPKAP-K2	77	4
MAPKAP-K3	68	5
MARK1	91	14
MARK2	88	1
MARK3	85	10
MARK4	74	3
MEKK1	79	7
MELK	74	4
MINK1	44	1
MKK1	85	5
MKK2	82	4
MKK6	99	26
MLK1	30	3
MLK3	30	0
MNK1	93	4
MNK2	103	3
MPSK1	83	9
MSK1	93	7
MST2	73	5
MST4	90	8
NEK2a	92	3
NEK6	102	19
NUAK1	66	8
p38 alpha MAPK	47	9
p38 beta MAPK	64	6
p38 delta MAPK	104	5
p38 gamma MAPK	106	16
PAK2	86	18
PAK4	93	2
PAK5	108	10
PAK6	84	6
PDK1	86	6
PHK	79	1
PIM1	18	1
PIM2	74	0
PIM3	12	0
PKA	81	4
PKB alpha	107	7
PKB beta	72	10
PKC alpha	106	12
PKC gamma	85	6
PKC zeta	99	6
PKD1	77	4
PLK1	97	5
PRAK	76	6
PRK2	81	8
RIPK2	70	3
ROCK 2	74	8
RSK1	109	3
RSK2	73	6
S6K1	80	2
SGK1	145	17
SmMLCK	51	3
Src	76	1
SRPK1	85	3
STK33	97	1
SYK	90	8
TAK1	100	8
TAO1	103	10
TBK1	92	4
TIE2	110	8
TrkA	107	20
TTK	81	9
VEGFR1	59	1
YES1	61	5
ZAP70	129	31