Inhibitor | SRT 1720  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	83	3
BRSK2	86	5
BTK	88	3
CAMK1	109	5
CAMKK beta	92	1
CDK2-Cyclin A	88	3
CHK1	86	5
CHK2	85	8
CK1 delta	99	9
CK2	90	7
CSK	97	4
DYRK1A	101	3
DYRK2	98	19
DYRK3	82	1
EF2K	102	4
EPH-A2	97	9
EPH-B3	99	14
ERK1	88	5
ERK2	93	16
ERK8	81	0
FGF-R1	103	18
GSK3 beta	85	31
HIPK3	88	6
IGF-1R	92	3
IKK beta	84	12
IKK epsilon	90	3
IR	127	11
IRR	73	0
JNK1	116	16
JNK2	101	12
Lck	88	9
MAPKAP-K2	90	2
MARK3	100	4
MELK	97	3
MKK1	91	0
MNK1	92	4
MNK2	90	3
MSK1	94	0
MST2	85	8
MST4	73	5
NEK2a	91	3
NEK6	84	3
p38 alpha MAPK	87	6
p38 beta MAPK	102	13
p38 delta MAPK	91	7
p38 gamma MAPK	84	8
PAK4	83	11
PAK5	79	11
PAK6	101	11
PDK1	108	9
PHK	96	1
PIM1	40	5
PIM2	90	0
PIM3	95	13
PKA	80	1
PKB alpha	86	3
PKB beta	75	15
PKC alpha	114	2
PKC zeta	78	8
PKD1	87	10
PLK1	84	13
PRAK	101	11
PRK2	90	8
ROCK 2	100	6
RSK1	88	6
RSK2	84	23
S6K1	86	6
SGK1	89	5
SmMLCK	82	2
Src	85	1
SRPK1	94	0
SYK	109	8
TBK1	97	0
VEGFR1	90	18
YES1	69	9

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	88	2
ASK1	98	2
Aurora A	102	3
Aurora B	93	1
BRSK1	94	6
BRSK2	97	0
BTK	99	9
CAMK1	83	1
CAMKK beta	83	2
CDK2-Cyclin A	100	5
CHK1	98	1
CHK2	93	0
CK1 delta	106	4
CK2	102	2
CLK2	60	10
CSK	85	8
DAPK1	68	1
DYRK1A	94	8
DYRK2	94	10
DYRK3	91	4
EF2K	106	4
EPH-A2	99	4
EPH-A4	78	1
EPH-B1	102	3
EPH-B2	82	5
EPH-B3	99	6
EPH-B4	96	6
ERK1	105	8
ERK2	103	4
ERK8	96	7
FGF-R1	91	13
GCK	102	2
GSK3 beta	78	3
HER4	80	11
HIPK1	104	2
HIPK2	86	6
HIPK3	92	8
IGF-1R	96	12
IKK beta	93	1
IKK epsilon	102	14
IR	101	5
IRAK4	63	9
IRR	77	1
JAK2	90	9
JNK1	103	12
JNK2	93	6
JNK3	105	0
Lck	106	15
LKB1	93	10
MAPKAP-K2	92	5
MAPKAP-K3	90	3
MARK1	85	1
MARK2	106	0
MARK3	108	6
MARK4	110	3
MEKK1	92	4
MELK	74	4
MINK1	91	5
MKK1	95	12
MKK2	109	1
MKK6	97	10
MLK1	92	3
MLK3	88	7
MNK1	100	8
MNK2	92	11
MSK1	90	7
MST2	96	10
MST4	100	3
NEK2a	95	3
NEK6	108	15
NUAK1	106	2
p38 alpha MAPK	91	13
p38 beta MAPK	89	11
p38 delta MAPK	78	1
p38 gamma MAPK	95	1
PAK2	107	1
PAK4	110	5
PAK5	91	4
PAK6	92	5
PDK1	97	0
PHK	53	3
PIM1	18	2
PIM2	95	9
PIM3	55	7
PKA	106	3
PKB alpha	91	6
PKB beta	70	10
PKC alpha	106	2
PKC zeta	105	1
PKD1	92	10
PLK1	94	6
PRAK	91	1
PRK2	103	12
RIPK2	100	1
ROCK 2	89	12
RSK1	66	3
RSK2	84	2
S6K1	111	11
SGK1	94	5
SmMLCK	27	0
Src	93	8
SRPK1	92	3
SYK	93	6
TAK1	91	14
TAO1	86	3
TBK1	91	5
TrkA	47	2
TTK	85	0
VEGFR1	89	4
YES1	82	7

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	60	3
ASK1	100	7
Aurora A	94	3
Aurora B	90	15
BRSK1	87	4
BRSK2	90	2
BTK	79	7
CAMK1	22	4
CAMKK beta	44	0
CDK2-Cyclin A	115	8
CHK1	96	9
CHK2	54	5
CK1 delta	91	5
CK2	77	2
CLK2	18	3
CSK	97	5
DAPK1	25	7
DYRK1A	58	1
DYRK2	94	2
DYRK3	64	5
EF2K	117	1
EPH-A2	84	6
EPH-A4	76	6
EPH-B1	88	0
EPH-B2	84	2
EPH-B3	90	5
EPH-B4	103	1
ERK1	117	13
ERK2	97	5
ERK8	86	1
FGF-R1	68	9
GCK	99	6
GSK3 beta	67	5
HER4	86	12
HIPK1	91	9
HIPK2	38	5
HIPK3	73	2
IGF-1R	25	2
IKK beta	84	5
IKK epsilon	83	8
IR	100	12
IRAK4	24	0
IRR	53	1
JAK2	86	14
JNK1	86	5
JNK2	87	4
JNK3	89	1
Lck	58	3
LKB1	97	2
MAPKAP-K2	59	5
MAPKAP-K3	100	11
MARK1	74	6
MARK2	83	7
MARK3	99	2
MARK4	85	11
MEKK1	45	1
MELK	52	11
MINK1	55	1
MKK1	87	8
MKK2	90	3
MKK6	98	8
MLK1	40	8
MLK3	56	0
MNK1	97	12
MNK2	96	1
MSK1	68	6
MST2	92	9
MST4	77	6
NEK2a	87	10
NEK6	83	9
NUAK1	78	2
p38 alpha MAPK	99	5
p38 beta MAPK	90	1
p38 delta MAPK	85	2
p38 gamma MAPK	92	4
PAK2	108	7
PAK4	96	7
PAK5	72	5
PAK6	87	4
PDK1	112	13
PHK	14	1
PIM1	10	2
PIM2	78	10
PIM3	24	0
PKA	84	9
PKB alpha	88	8
PKB beta	61	6
PKC alpha	80	5
PKC zeta	103	0
PKD1	105	10
PLK1	104	5
PRAK	105	2
PRK2	104	8
RIPK2	95	14
ROCK 2	79	2
RSK1	34	1
RSK2	46	2
S6K1	61	11
SGK1	84	3
SmMLCK	10	3
Src	121	1
SRPK1	86	4
SYK	67	9
TAK1	86	2
TAO1	97	6
TBK1	56	1
TrkA	30	4
TTK	68	5
VEGFR1	53	3
YES1	80	3