Inhibitor |
SP600125 (JNK Inhibitor II, SAPK Inhibitor II)
Screening Results Tables
Screen Conc:
1.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
44
|
4
|
|
Aurora B
|
14
|
0
|
|
Aurora C
|
20
|
2
|
|
BRSK2
|
43
|
8
|
|
CAMK1
|
73
|
1
|
|
CAMKK alpha
|
68
|
7
|
|
CAMKK beta
|
40
|
3
|
|
CDK2-Cyclin A
|
49
|
1
|
|
CHK1
|
62
|
2
|
|
CHK2
|
44
|
4
|
|
CK1 delta
|
15
|
0
|
|
CK2
|
57
|
4
|
|
CSK
|
64
|
4
|
|
DYRK1A
|
40
|
1
|
|
DYRK2
|
18
|
1
|
|
DYRK3
|
30
|
7
|
|
EF2K
|
118
|
1
|
|
ERK1
|
88
|
4
|
|
ERK2
|
85
|
2
|
|
ERK8
|
42
|
1
|
|
GSK3 beta
|
81
|
4
|
|
HIPK2
|
34
|
7
|
|
HIPK3
|
55
|
4
|
|
IKK beta
|
48
|
3
|
|
JNK1
|
22
|
1
|
|
JNK2
|
24
|
2
|
|
JNK3
|
47
|
0
|
|
Lck
|
67
|
2
|
|
MAPKAP-K2
|
102
|
2
|
|
MAPKAP-K3
|
103
|
0
|
|
MARK3
|
49
|
5
|
|
MELK
|
14
|
3
|
|
MKK1
|
58
|
7
|
|
MNK1
|
67
|
3
|
|
MNK2
|
58
|
4
|
|
MSK1
|
72
|
9
|
|
MST2
|
31
|
4
|
|
NEK2a
|
77
|
1
|
|
NEK6
|
102
|
4
|
|
NEK7
|
112
|
6
|
|
p38 alpha MAPK
|
109
|
2
|
|
p38 beta MAPK
|
106
|
1
|
|
p38 delta MAPK
|
82
|
2
|
|
p38 gamma MAPK
|
85
|
1
|
|
PAK4
|
60
|
3
|
|
PAK5
|
81
|
0
|
|
PAK6
|
71
|
5
|
|
PDK1
|
55
|
5
|
|
PHK
|
30
|
0
|
|
PIM1
|
39
|
2
|
|
PIM2
|
57
|
2
|
|
PIM3
|
17
|
0
|
|
PKA
|
79
|
5
|
|
PKB alpha
|
97
|
1
|
|
PKB beta
|
92
|
1
|
|
PKC alpha
|
67
|
5
|
|
PKC zeta
|
106
|
2
|
|
PKD1
|
25
|
0
|
|
PLK1
|
80
|
2
|
|
PRAK
|
58
|
8
|
|
PRK2
|
70
|
5
|
|
ROCK 2
|
91
|
2
|
|
RSK1
|
55
|
0
|
|
RSK2
|
69
|
1
|
|
S6K1
|
84
|
1
|
|
SGK1
|
27
|
0
|
|
SmMLCK
|
34
|
4
|
|
Src
|
88
|
1
|
|
SRPK1
|
83
|
4
|
