Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Download CSV
Download CSV
Inhibitor Brutto MW Action Reference Reference 2
SU-5416 (VEGFR2 Kinase Inhibitor III)   C15H14N2O 238.30 VEGF-R Tille J.C. (2003) Exp. Cell Res. 285 286 Itokawa T. (2002) Mol. Cancer Ther. 1 295
SU-6656   C19H21N3O3S 371.50 Src Bowman T. (2001) Proc. Natl. Acad. Sci. USA 98 7319 Blake R.A. (2000) Mol. Cell. Biol. 20 9018
SU-6668   C18H18N2O3 310.35 Aurora Godl K. (2005) Cancer Res. 65 6919-6926.
Sulfasalazine   C18H14N4O5S 398.39 glutathione-S-transferase Liptay S. (1999) Br. J. Pharmacol. 128 1361 Volin M.V. (1999) Arthritis Rheum. 42 1927
Sunitinib   C22H27FN4O2 398.47 RTK, Multiple Tyrosine Kinases Targeted Sakamoto K. M. (2004) Curr Opin Investig Drugs 5(12) 1329-39
Surufatinib   C24H28N6O3S 480.60 VEGFR1-3
SYK Inhibitor I   C18H15N3O3S 353.40 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111
SYK Inhibitor II   C14H15F3N6O • 2HCl•2H2O 449.30 SYK Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936
SYK Inhibitor III   C9H7NO4 193.20 SYK Wang W.Y. (2006) Mol. Pharmacol. 70 1380
SYK Inhibitor IV (BAY 61-3606)   C20H18N6O3 • HCl • H2O 444.90 SYK Yamamoto N. (2003) J Pharmacol Exp Ther 306 1174
TAE684 C30H40ClN7O3S 614.22 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869 Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275
Temsirolimus   C56H87NO16 mTOR
Tenalisib   C23H18FN5O2 415.40 PI3K δ/ γ
Tenovin-6   C25H34N4O2S 454.60
Tepotinib   C29H28N6O2 492.60 MET ex 14 alterations
TG003   C13H15NO2S 249.33 Cdc2-like kinase Muraki M. (2004) J. Biol. Chem. 279 24246-24254
Tirabrutinib   C25H22N6O3 454.50 BTK
Tirbanibulin   C26H29N3O3 431.50 Src; tubulin
Tivozanib   C22H19ClN4O5 454.90 VEGFR
Tofacitinib   312.37 JAK3
Download CSV
Download CSV