This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.
We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.
If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.
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| Inhibitor | Brutto | MW | Action | Reference | Reference 2 |
|---|---|---|---|---|---|
| Wortmannin (KY 12420) | C23H24O8 | 428.40 | PI3K | Cross M.J. (1995) J. Biol. Chem. 270 25352 | Nakamura I. (1995) FEBS Lett. 361 79 |
| WP1130 | C19H18BrN3O | 384.27 | DUB | V Kapuria (2011) Cell Signal 23(12) 2076-2085. | V Kapuria (2010) Cancer Res 70(22) 9265-9276 |
| Wyeth PDK1 Inhibitor Compound 1 | C19H22Cl4N4O2 | 480.21 | PDK1 | Gopalsamy A. (2007) Journal of Medicinal Chemistry 50 (23) 5547-5549 | |
| Y-27632 | C14H21N3O • 2HCl • H2O | 338.30 | ROCK | Watanabe K. (2007) Nature Biotech. 25 681 | Chitaley K. (2001) Nat. Med. 7 119 |
| Zanubrutinib | C27H29N5O3 | 471.50 | BTK | ||
| Zearalenone | C18H22O5 | 318.40 | Estrogen receptor (ER) | Powell-Jones W. (1981) Mol. Pharmacol. 20 35-42 | |
| ZM 336372 | C23H23N3O3 | 389.40 | c-Raf | Hall-Jackson C.A. (1999) Chem. Biol. 6 559 |