Inhibitor | SB-747651A  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	102	4
AMPK	95	10
AMPK (hum)	115	3
ASK1	100	4
Aurora A	91	13
Aurora B	85	3
BRK	91	18
BRSK1	91	10
BRSK2	96	13
BTK	92	1
CAMK1	119	11
CAMKK beta	121	20
CDK2-Cyclin A	83	2
CDK9-Cyclin T1	103	6
CHK1	89	2
CHK2	94	1
CK1 delta	102	2
CK1 gamma 2	101	9
CK2	71	7
CLK2	107	5
CSK	89	5
DAPK1	111	13
DDR2	108	2
DYRK1A	92	6
DYRK2	87	5
DYRK3	107	6
EF2K	118	2
EIF2AK3	93	13
EPH-A2	119	4
EPH-A4	116	31
EPH-B1	92	0
EPH-B2	115	5
EPH-B3	81	6
EPH-B4	105	14
ERK1	95	4
ERK2	113	11
ERK5	96	3
ERK8	95	9
FGF-R1	101	2
GCK	91	2
GSK3 beta	87	2
HER4	112	8
HIPK1	107	14
HIPK2	112	2
HIPK3	99	6
IGF-1R	96	3
IKK beta	98	5
IKK epsilon	111	18
IR	99	1
IRAK1	99	18
IRAK4	99	4
IRR	71	3
JAK2	108	2
JNK1	112	2
JNK2	109	2
JNK3	97	6
Lck	102	4
LKB1	108	13
MAP4K3	99	6
MAP4K5	107	6
MAPKAP-K2	112	11
MAPKAP-K3	98	3
MARK1	85	9
MARK2	99	16
MARK3	88	2
MARK4	91	4
MEKK1	94	6
MELK	71	6
MINK1	107	17
MKK1	85	9
MKK2	98	14
MKK6	89	7
MLK1	105	16
MLK3	97	26
MNK1	91	3
MNK2	110	3
MPSK1	108	30
MSK1	22	3
MST2	106	12
MST3	86	7
MST4	91	7
NEK2a	98	3
NEK6	103	9
NUAK1	101	2
OSR1	107	5
p38 alpha MAPK	101	0
p38 beta MAPK	102	3
p38 delta MAPK	100	0
p38 gamma MAPK	119	4
PAK2	99	0
PAK4	105	37
PAK5	93	1
PAK6	103	4
PDGFRA	120	4
PDK1	96	4
PHK	101	8
PIM1	94	12
PIM2	149	33
PIM3	76	2
PKA	79	1
PKB alpha	48	1
PKB beta	101	16
PKC alpha	84	5
PKC gamma	96	9
PKC zeta	94	7
PKD1	86	1
PLK1	83	14
PRAK	94	4
PRK2	31	0
RIPK2	86	9
ROCK 2	31	6
RSK1	33	2
RSK2	94	11
S6K1	16	3
SGK1	82	8
SIK2	97	2
SIK3	89	11
SmMLCK	104	2
Src	110	3
SRPK1	94	9
STK33	104	6
SYK	106	3
TAK1	95	12
TAO1	100	2
TBK1	88	2
TESK1	103	10
TGFBR1	85	18
TIE2	122	33
TLK1	92	3
TrkA	104	9
TSSK1	88	5
TTBK1	104	14
TTBK2	91	7
TTK	83	0
ULK1	83	1
ULK2	93	2
VEGFR1	103	2
WNK1	106	0
YES1	108	5
ZAP70	83	15

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	109	9
AMPK	82	0
AMPK (hum)	78	8
ASK1	97	9
Aurora A	95	3
Aurora B	76	8
BRK	99	20
BRSK1	81	4
BRSK2	89	7
BTK	93	3
CAMK1	109	4
CAMKK beta	128	18
CDK2-Cyclin A	81	1
CDK9-Cyclin T1	115	6
CHK1	88	15
CHK2	89	1
CK1 delta	91	15
CK1 gamma 2	92	4
CK2	74	0
CLK2	71	5
CSK	95	7
DAPK1	84	4
DDR2	97	3
DYRK1A	73	6
DYRK2	89	3
DYRK3	93	14
EF2K	119	29
EIF2AK3	105	10
EPH-A2	114	7
EPH-A4	109	19
EPH-B1	99	9
EPH-B2	91	1
EPH-B3	99	1
EPH-B4	105	17
ERK1	98	11
ERK2	117	3
ERK5	83	8
ERK8	62	1
FGF-R1	115	6
GCK	94	9
GSK3 beta	66	2
HER4	104	3
HIPK1	107	5
HIPK2	82	3
HIPK3	95	1
IGF-1R	107	2
IKK beta	97	8
IKK epsilon	110	17
IR	99	2
IRAK1	103	9
IRAK4	86	4
IRR	49	1
JAK2	103	3
JNK1	105	5
JNK2	103	3
JNK3	109	29
Lck	99	7
LKB1	94	20
MAP4K3	110	32
MAP4K5	103	2
MAPKAP-K2	104	4
MAPKAP-K3	101	2
MARK1	95	5
MARK2	92	2
MARK3	87	2
MARK4	103	17
MEKK1	93	2
MELK	40	6
MINK1	96	5
MKK1	103	0
MKK2	135	20
MKK6	90	1
MLK1	104	2
MLK3	111	12
MNK1	100	4
MNK2	116	8
MPSK1	103	9
MSK1	5	0
MST2	97	2
MST3	91	11
MST4	81	8
NEK2a	93	6
NEK6	101	3
NUAK1	91	3
OSR1	102	6
p38 alpha MAPK	95	7
p38 beta MAPK	96	6
p38 delta MAPK	99	1
p38 gamma MAPK	112	3
PAK2	93	2
PAK4	96	10
PAK5	100	9
PAK6	94	13
PDGFRA	101	2
PDK1	95	17
PHK	101	16
PIM1	35	2
PIM2	110	5
PIM3	36	5
PKA	33	2
PKB alpha	16	6
PKB beta	59	11
PKC alpha	70	0
PKC gamma	80	4
PKC zeta	71	1
PKD1	93	7
PLK1	60	3
PRAK	95	0
PRK2	12	3
RIPK2	77	5
ROCK 2	23	1
RSK1	15	5
RSK2	61	36
S6K1	5	0
SGK1	55	3
SIK2	93	5
SIK3	94	6
SmMLCK	110	8
Src	120	6
SRPK1	99	16
STK33	106	16
SYK	101	7
TAK1	94	8
TAO1	108	7
TBK1	93	13
TESK1	114	17
TGFBR1	90	5
TIE2	116	2
TLK1	92	3
TrkA	99	2
TSSK1	88	22
TTBK1	100	15
TTBK2	95	12
TTK	84	4
ULK1	74	6
ULK2	98	5
VEGFR1	105	1
WNK1	102	5
YES1	98	3
ZAP70	84	0

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	96	3
AMPK	29	3
AMPK (hum)	34	7
ASK1	97	11
Aurora A	103	1
Aurora B	71	3
BRK	91	17
BRSK1	41	0
BRSK2	41	6
BTK	112	9
CAMK1	109	3
CAMKK beta	105	11
CDK2-Cyclin A	56	2
CDK9-Cyclin T1	103	6
CHK1	53	2
CHK2	69	5
CK1 delta	61	9
CK1 gamma 2	92	0
CK2	86	7
CLK2	22	2
CSK	98	3
DAPK1	35	2
DDR2	104	10
DYRK1A	35	10
DYRK2	53	5
DYRK3	72	12
EF2K	117	16
EIF2AK3	94	4
EPH-A2	103	8
EPH-A4	103	25
EPH-B1	82	10
EPH-B2	87	3
EPH-B3	83	0
EPH-B4	94	12
ERK1	97	3
ERK2	115	4
ERK5	64	6
ERK8	27	5
FGF-R1	121	6
GCK	71	7
GSK3 beta	25	3
HER4	115	20
HIPK1	84	5
HIPK2	43	4
HIPK3	84	12
IGF-1R	105	2
IKK beta	100	1
IKK epsilon	115	6
IR	99	2
IRAK1	75	1
IRAK4	87	17
IRR	21	0
JAK2	110	4
JNK1	101	9
JNK2	95	10
JNK3	95	11
Lck	94	10
LKB1	57	0
MAP4K3	66	7
MAP4K5	84	13
MAPKAP-K2	102	4
MAPKAP-K3	97	14
MARK1	71	7
MARK2	63	11
MARK3	56	13
MARK4	81	0
MEKK1	112	13
MELK	26	6
MINK1	72	5
MKK1	78	5
MKK2	126	27
MKK6	96	10
MLK1	99	16
MLK3	89	5
MNK1	90	3
MNK2	77	4
MPSK1	83	9
MSK1	1	1
MST2	71	0
MST3	73	5
MST4	91	16
NEK2a	106	17
NEK6	102	14
NUAK1	59	7
OSR1	97	1
p38 alpha MAPK	94	6
p38 beta MAPK	89	1
p38 delta MAPK	88	7
p38 gamma MAPK	109	9
PAK2	90	3
PAK4	79	3
PAK5	98	0
PAK6	93	5
PDGFRA	99	3
PDK1	73	2
PHK	75	5
PIM1	7	1
PIM2	69	14
PIM3	13	0
PKA	8	1
PKB alpha	4	1
PKB beta	38	10
PKC alpha	30	5
PKC gamma	46	6
PKC zeta	25	5
PKD1	76	1
PLK1	41	3
PRAK	96	11
PRK2	7	1
RIPK2	77	8
ROCK 2	17	14
RSK1	9	2
RSK2	64	62
S6K1	4	2
SGK1	25	2
SIK2	95	6
SIK3	89	10
SmMLCK	70	3
Src	102	17
SRPK1	86	15
STK33	74	1
SYK	79	2
TAK1	82	3
TAO1	104	18
TBK1	78	0
TESK1	104	15
TGFBR1	92	2
TIE2	111	4
TLK1	88	2
TrkA	97	1
TSSK1	42	11
TTBK1	91	1
TTBK2	101	11
TTK	65	3
ULK1	43	1
ULK2	73	4
VEGFR1	83	9
WNK1	100	11
YES1	86	8
ZAP70	84	16