Inhibitor | SB-505124  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	91	3
AMPK	104	6
ASK1	104	2
Aurora A	123	1
Aurora B	120	4
BRK	103	1
BRSK1	109	1
BRSK2	100	26
BTK	94	1
CAMK1	93	1
CAMKK beta	101	2
CDK2-Cyclin A	99	9
CHK1	115	8
CHK2	104	12
CK1 delta	104	0
CK2	95	4
CLK2	113	15
CSK	106	3
DAPK1	91	5
DYRK1A	100	17
DYRK2	87	1
DYRK3	98	2
EF2K	99	5
EIF2AK3	103	4
EPH-A2	101	9
EPH-A4	104	5
EPH-B1	95	5
EPH-B2	100	4
EPH-B3	115	13
EPH-B4	111	5
ERK1	99	15
ERK2	114	5
ERK8	81	4
FGF-R1	105	4
GCK	101	2
GSK3 beta	102	4
HER4	102	13
HIPK1	91	9
HIPK2	109	10
HIPK3	98	7
IGF-1R	107	3
IKK beta	117	8
IKK epsilon	99	18
IR	100	4
IRAK1	78	2
IRAK4	109	9
IRR	114	6
JAK2	96	21
JNK1	101	6
JNK2	101	5
JNK3	99	2
Lck	98	12
LKB1	113	6
MAPKAP-K2	103	7
MAPKAP-K3	99	15
MARK1	101	16
MARK2	93	6
MARK3	100	7
MARK4	100	3
MEKK1	152	49
MELK	107	4
MINK1	110	8
MKK1	107	16
MKK2	101	13
MKK6	110	10
MLK1	99	2
MLK3	93	9
MNK1	103	14
MNK2	100	2
MPSK1	99	6
MSK1	113	8
MST2	110	16
MST4	103	7
NEK2a	103	2
NEK6	98	2
NUAK1	95	3
OSR1	94	9
p38 alpha MAPK	93	7
p38 beta MAPK	97	7
p38 delta MAPK	92	4
p38 gamma MAPK	102	11
PAK2	113	5
PAK4	112	4
PAK5	93	15
PAK6	111	9
PDK1	99	24
PHK	107	5
PIM1	113	7
PIM2	101	5
PIM3	105	4
PKA	92	6
PKB alpha	97	5
PKB beta	106	8
PKC alpha	92	1
PKC gamma	104	10
PKC zeta	94	5
PKD1	106	1
PLK1	106	4
PRAK	100	15
PRK2	111	5
RIPK2	82	1
ROCK 2	106	10
RSK1	108	16
RSK2	102	0
S6K1	117	12
SGK1	108	3
SmMLCK	86	11
Src	95	7
SRPK1	107	10
STK33	102	7
SYK	115	9
TAK1	113	7
TAO1	90	11
TBK1	97	5
TIE2	109	2
TLK1	95	0
TrkA	116	10
TTK	89	12
VEGFR1	83	6
YES1	122	15
ZAP70	109	15

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	101	0
AMPK	104	3
ASK1	111	7
Aurora A	123	0
Aurora B	124	14
BRK	107	16
BRSK1	120	10
BRSK2	113	21
BTK	99	19
CAMK1	95	4
CAMKK beta	113	18
CDK2-Cyclin A	107	15
CHK1	119	3
CHK2	123	8
CK1 delta	104	15
CK2	102	12
CLK2	112	8
CSK	121	9
DAPK1	94	6
DYRK1A	107	6
DYRK2	111	14
DYRK3	100	11
EF2K	106	3
EIF2AK3	101	4
EPH-A2	122	23
EPH-A4	112	9
EPH-B1	109	5
EPH-B2	129	7
EPH-B3	121	0
EPH-B4	111	9
ERK1	103	10
ERK2	123	1
ERK8	97	11
FGF-R1	110	5
GCK	97	1
GSK3 beta	95	11
HER4	116	2
HIPK1	107	7
HIPK2	112	5
HIPK3	102	2
IGF-1R	101	14
IKK beta	121	0
IKK epsilon	109	12
IR	97	2
IRAK1	110	8
IRAK4	103	4
IRR	112	5
JAK2	109	4
JNK1	110	7
JNK2	108	2
JNK3	115	6
Lck	118	1
LKB1	110	9
MAPKAP-K2	120	20
MAPKAP-K3	93	9
MARK1	117	8
MARK2	98	21
MARK3	101	1
MARK4	107	11
MEKK1	125	3
MELK	110	4
MINK1	122	0
MKK1	111	10
MKK2	115	3
MKK6	113	12
MLK1	110	5
MLK3	106	14
MNK1	109	7
MNK2	102	10
MPSK1	120	12
MSK1	100	14
MST2	121	11
MST4	106	6
NEK2a	109	2
NEK6	102	6
NUAK1	98	2
OSR1	97	6
p38 alpha MAPK	51	7
p38 beta MAPK	99	0
p38 delta MAPK	96	2
p38 gamma MAPK	84	2
PAK2	133	8
PAK4	105	2
PAK5	93	7
PAK6	103	15
PDK1	118	24
PHK	104	4
PIM1	131	0
PIM2	100	6
PIM3	101	2
PKA	101	3
PKB alpha	105	12
PKB beta	109	21
PKC alpha	100	0
PKC gamma	111	8
PKC zeta	105	1
PKD1	105	0
PLK1	109	3
PRAK	111	13
PRK2	96	0
RIPK2	28	1
ROCK 2	103	10
RSK1	121	18
RSK2	92	5
S6K1	110	9
SGK1	106	1
SmMLCK	97	3
Src	119	11
SRPK1	94	7
STK33	105	15
SYK	117	7
TAK1	120	5
TAO1	99	12
TBK1	103	21
TIE2	119	12
TLK1	101	10
TrkA	114	3
TTK	99	5
VEGFR1	97	2
YES1	105	5
ZAP70	105	2