Protein transformations that change lives

Inhibitor | Saracatinib (AZD0530)

Compound name	Brutto	MW	CAS	PubChem CID	Action	Reference	Reference
Saracatinib (AZD0530)	C₂₇H₃₂ClN₅O₅	542.03	379231-04-6	10302451	Src	H Laurent (2006) J. Med. Chem. 49(22) 6465-6488

Screen Conc: 0.10µM
Kinase	% Activity Remaining	Standard Deviation
ABL	27	1
AMPK	118	17
AMPK (hum)	125	12
ASK1	100	1
Aurora A	100	9
Aurora B	91	5
BRK	30	13
BRSK1	121	9
BRSK2	107	14
BTK	73	14
CAMK1	97	0
CAMKK beta	107	4
CDK2-Cyclin A	100	5
CDK9-Cyclin T1	91	2
CHK1	100	15
CHK2	100	11
CK1 delta	119	7
CK1 gamma 2	102	3
CK2	93	15
CLK2	107	1
CSK	79	4
DAPK1	100	22
DDR2	20	4
DYRK1A	105	9
DYRK2	108	4
DYRK3	100	1
EF2K	101	1
EIF2AK3	105	3
EPH-A2	48	2
EPH-A4	34	3
EPH-B1	60	9
EPH-B2	63	2
EPH-B3	121	14
EPH-B4	58	11
ERK1	99	8
ERK2	114	11
ERK5	96	1
ERK8	122	6
FGF-R1	91	14
GCK	94	16
GSK3 beta	103	5
HER4	45	7
HIPK1	109	19
HIPK2	95	12
HIPK3	101	1
IGF-1R	98	20
IKK beta	109	7
IKK epsilon	131	8
IR	113	15
IRAK1	109	13
IRAK4	97	7
IRR	105	1
JAK2	104	7
JNK1	103	2
JNK2	87	4
JNK3	113	1
Lck	108	2
LKB1	116	36
MAP4K3	108	9
MAP4K5	77	1
MAPKAP-K2	106	9
MAPKAP-K3	94	14
MARK1	114	20
MARK2	115	9
MARK3	125	5
MARK4	114	13
MEKK1	109	10
MELK	128	5
MINK1	84	6
MKK1	111	11
MKK2	114	1
MKK6	118	12
MLK1	108	30
MLK3	121	0
MNK1	119	2
MNK2	109	0
MPSK1	114	8
MSK1	115	12
MST2	93	0
MST3	123	21
MST4	89	15
NEK2a	102	1
NEK6	128	2
NUAK1	118	9
OSR1	102	8
p38 alpha MAPK	106	1
p38 beta MAPK	87	9
p38 delta MAPK	99	7
p38 gamma MAPK	107	3
PAK2	90	15
PAK4	111	11
PAK5	104	4
PAK6	104	4
PDGFRA	100	2
PDK1	101	15
PHK	109	9
PIM1	101	26
PIM2	90	3
PIM3	108	7
PINK	102	6
PKA	100	6
PKB alpha	112	12
PKB beta	101	11
PKC alpha	65	28
PKC gamma	113	10
PKC zeta	107	4
PKD1	110	2
PLK1	122	2
PRAK	110	6
PRK2	96	1
RIPK2	19	6
ROCK 2	145	13
RSK1	89	8
RSK2	114	7
S6K1	108	10
SGK1	101	2
SIK2	39	9
SIK3	82	22
SmMLCK	92	1
Src	3	1
SRPK1	110	32
STK33	87	3
SYK	87	3
TAK1	124	5
TAO1	107	3
TBK1	71	20
TESK1	97	0
TGFBR1	143	3
TIE2	89	22
TLK1	109	6
TrkA	71	1
TSSK1	100	2
TTBK1	104	2
TTBK2	104	2
TTK	78	37
ULK1	96	2
ULK2	101	1
VEGFR1	106	1
WNK1	118	5
YES1	30	13
ZAP70	106	11

Screen Conc: 1.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	3	1
AMPK	130	20
AMPK (hum)	113	12
ASK1	96	5
Aurora A	115	4
Aurora B	97	2
BRK	3	3
BRSK1	109	0
BRSK2	114	18
BTK	21	3
CAMK1	108	3
CAMKK beta	102	5
CDK2-Cyclin A	115	6
CDK9-Cyclin T1	96	2
CHK1	110	12
CHK2	114	6
CK1 delta	105	10
CK1 gamma 2	114	11
CK2	88	7
CLK2	112	1
CSK	28	10
DAPK1	117	16
DDR2	2	0
DYRK1A	106	9
DYRK2	106	2
DYRK3	106	3
EF2K	113	8
EIF2AK3	97	4
EPH-A2	14	4
EPH-A4	7	1
EPH-B1	13	0
EPH-B2	49	7
EPH-B3	80	13
EPH-B4	8	1
ERK1	94	13
ERK2	118	5
ERK5	87	3
ERK8	110	7
FGF-R1	92	8
GCK	85	5
GSK3 beta	93	11
HER4	82	6
HIPK1	172	95
HIPK2	101	2
HIPK3	105	3
IGF-1R	97	3
IKK beta	95	6
IKK epsilon	116	5
IR	111	6
IRAK1	54	7
IRAK4	64	3
IRR	83	4
JAK2	84	2
JNK1	101	5
JNK2	100	8
JNK3	105	5
Lck	115	14
LKB1	95	8
MAP4K3	105	1
MAP4K5	25	3
MAPKAP-K2	109	5
MAPKAP-K3	108	7
MARK1	94	7
MARK2	113	10
MARK3	124	7
MARK4	102	7
MEKK1	101	8
MELK	111	9
MINK1	36	2
MKK1	103	1
MKK2	99	17
MKK6	145	7
MLK1	101	9
MLK3	92	11
MNK1	113	1
MNK2	104	13
MPSK1	108	3
MSK1	99	3
MST2	93	6
MST3	105	6
MST4	103	4
NEK2a	113	5
NEK6	115	22
NUAK1	115	4
OSR1	95	8
p38 alpha MAPK	71	1
p38 beta MAPK	92	6
p38 delta MAPK	91	7
p38 gamma MAPK	91	7
PAK2	100	1
PAK4	114	1
PAK5	96	3
PAK6	106	6
PDGFRA	77	6
PDK1	103	9
PHK	109	4
PIM1	104	20
PIM2	88	4
PIM3	106	11
PINK	113	1
PKA	101	9
PKB alpha	103	4
PKB beta	112	4
PKC alpha	97	1
PKC gamma	101	20
PKC zeta	98	3
PKD1	109	3
PLK1	104	8
PRAK	109	0
PRK2	98	0
RIPK2	14	7
ROCK 2	142	12
RSK1	101	12
RSK2	123	2
S6K1	93	4
SGK1	96	2
SIK2	10	1
SIK3	50	5
SmMLCK	97	1
Src	1	1
SRPK1	120	1
STK33	92	6
SYK	77	11
TAK1	112	3
TAO1	108	4
TBK1	92	8
TESK1	83	6
TGFBR1	64	3
TIE2	102	7
TLK1	101	9
TrkA	28	5
TSSK1	96	15
TTBK1	109	7
TTBK2	97	0
TTK	92	1
ULK1	99	2
ULK2	91	10
VEGFR1	94	2
WNK1	105	1
YES1	9	7
ZAP70	111	8