Inhibitor | Ruxolitinib  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	100	5
AMPK	107	6
ASK1	107	3
Aurora A	95	15
Aurora B	112	10
BRK	101	4
BRSK1	96	2
BRSK2	93	3
BTK	76	12
CAMK1	91	10
CAMKK beta	116	4
CDK2-Cyclin A	96	11
CHK1	99	0
CHK2	97	10
CK1 delta	94	11
CK2	99	1
CLK2	73	2
CSK	75	3
DAPK1	78	7
DYRK1A	101	3
DYRK2	102	15
DYRK3	97	1
EF2K	82	15
EIF2AK3	89	2
EPH-A2	107	6
EPH-A4	85	4
EPH-B1	71	2
EPH-B2	118	14
EPH-B3	96	9
EPH-B4	78	9
ERK1	97	13
ERK2	115	15
ERK8	113	5
FGF-R1	79	9
GCK	86	9
GSK3 beta	100	8
HER4	106	6
HIPK1	102	4
HIPK2	94	3
HIPK3	116	3
IGF-1R	94	11
IKK beta	96	10
IKK epsilon	93	4
IR	95	9
IRAK1	63	12
IRAK4	92	4
IRR	88	6
JAK2	3	1
JNK1	84	3
JNK2	95	8
JNK3	110	3
Lck	95	1
LKB1	95	8
MAPKAP-K2	102	13
MAPKAP-K3	89	1
MARK1	96	7
MARK2	97	6
MARK3	83	1
MARK4	94	20
MEKK1	90	8
MELK	81	11
MINK1	91	4
MKK1	108	10
MKK2	99	4
MKK6	95	5
MLK1	82	13
MLK3	90	1
MNK1	81	9
MNK2	88	11
MPSK1	104	4
MSK1	84	0
MST2	97	28
MST4	100	15
NEK2a	108	22
NEK6	88	4
NUAK1	87	10
OSR1	95	2
p38 alpha MAPK	85	15
p38 beta MAPK	101	13
p38 delta MAPK	90	14
p38 gamma MAPK	94	15
PAK2	93	4
PAK4	96	3
PAK5	94	15
PAK6	96	10
PDK1	89	6
PHK	60	3
PIM1	104	1
PIM2	87	5
PIM3	90	13
PKA	95	11
PKB alpha	102	12
PKB beta	86	15
PKC alpha	88	14
PKC gamma	93	8
PKC zeta	99	3
PKD1	101	6
PLK1	108	1
PRAK	83	16
PRK2	84	5
RIPK2	88	1
ROCK 2	60	9
RSK1	82	6
RSK2	92	4
S6K1	91	16
SGK1	100	13
SmMLCK	101	3
Src	67	14
SRPK1	85	13
STK33	108	1
SYK	96	18
TAK1	85	2
TAO1	104	1
TBK1	88	1
TIE2	98	4
TLK1	82	3
TrkA	32	1
TTK	95	7
VEGFR1	85	14
YES1	75	10
ZAP70	95	7

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	101	2
AMPK	89	10
ASK1	77	8
Aurora A	26	0
Aurora B	95	7
BRK	84	11
BRSK1	96	0
BRSK2	92	3
BTK	58	2
CAMK1	58	0
CAMKK beta	104	2
CDK2-Cyclin A	57	6
CHK1	106	7
CHK2	65	14
CK1 delta	74	6
CK2	77	6
CLK2	21	2
CSK	63	6
DAPK1	32	2
DYRK1A	67	1
DYRK2	86	12
DYRK3	107	3
EF2K	83	12
EIF2AK3	94	2
EPH-A2	62	1
EPH-A4	58	5
EPH-B1	48	4
EPH-B2	79	7
EPH-B3	86	9
EPH-B4	59	0
ERK1	111	5
ERK2	102	3
ERK8	100	8
FGF-R1	34	4
GCK	44	2
GSK3 beta	62	4
HER4	90	5
HIPK1	95	6
HIPK2	69	2
HIPK3	114	7
IGF-1R	100	5
IKK beta	105	3
IKK epsilon	73	8
IR	89	1
IRAK1	19	4
IRAK4	85	4
IRR	97	9
JAK2	2	1
JNK1	95	11
JNK2	89	13
JNK3	94	1
Lck	69	8
LKB1	83	8
MAPKAP-K2	102	9
MAPKAP-K3	101	2
MARK1	55	3
MARK2	42	7
MARK3	13	6
MARK4	88	1
MEKK1	89	6
MELK	42	7
MINK1	94	5
MKK1	73	6
MKK2	93	4
MKK6	101	8
MLK1	34	2
MLK3	46	10
MNK1	66	5
MNK2	39	1
MPSK1	101	5
MSK1	29	1
MST2	68	8
MST4	105	5
NEK2a	82	1
NEK6	92	1
NUAK1	26	1
OSR1	74	1
p38 alpha MAPK	83	1
p38 beta MAPK	102	16
p38 delta MAPK	66	3
p38 gamma MAPK	86	5
PAK2	99	2
PAK4	57	0
PAK5	72	4
PAK6	70	1
PDK1	66	8
PHK	15	0
PIM1	112	11
PIM2	90	12
PIM3	85	10
PKA	53	2
PKB alpha	77	15
PKB beta	87	4
PKC alpha	67	5
PKC gamma	80	2
PKC zeta	95	1
PKD1	83	0
PLK1	95	6
PRAK	84	3
PRK2	61	7
RIPK2	83	4
ROCK 2	36	4
RSK1	68	9
RSK2	81	3
S6K1	78	1
SGK1	75	10
SmMLCK	75	7
Src	62	4
SRPK1	67	4
STK33	84	7
SYK	83	30
TAK1	60	1
TAO1	85	15
TBK1	73	0
TIE2	78	3
TLK1	80	8
TrkA	18	3
TTK	44	2
VEGFR1	74	8
YES1	59	5
ZAP70	92	16