Inhibitor |
SC514 ( IKK-2 Inhibitor)
Screen Conc:
10.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
77
|
10
|
|
Aurora B
|
50
|
4
|
|
Aurora C
|
70
|
2
|
|
BRSK2
|
77
|
2
|
|
CAMK1
|
87
|
7
|
|
CAMKK alpha
|
90
|
4
|
|
CAMKK beta
|
87
|
1
|
|
CDK2-Cyclin A
|
84
|
7
|
|
CHK1
|
69
|
9
|
|
CHK2
|
93
|
12
|
|
CK1 delta
|
91
|
12
|
|
CK2
|
75
|
6
|
|
CSK
|
81
|
2
|
|
DYRK1A
|
41
|
1
|
|
DYRK2
|
66
|
4
|
|
DYRK3
|
47
|
6
|
|
EF2K
|
113
|
6
|
|
EPH-A2
|
74
|
2
|
|
ERK1
|
88
|
6
|
|
ERK2
|
96
|
9
|
|
ERK8
|
47
|
2
|
|
FGF-R1
|
63
|
10
|
|
GSK3 beta
|
76
|
2
|
|
HIPK2
|
47
|
2
|
|
HIPK3
|
77
|
7
|
|
IKK beta
|
28
|
1
|
|
IKK epsilon
|
93
|
1
|
|
IRR
|
63
|
4
|
|
JNK1
|
89
|
4
|
|
JNK2
|
93
|
7
|
|
JNK3
|
94
|
9
|
|
Lck
|
70
|
7
|
|
MAPKAP-K2
|
97
|
3
|
|
MAPKAP-K3
|
92
|
3
|
|
MARK3
|
64
|
5
|
|
MELK
|
80
|
5
|
|
MKK1
|
83
|
8
|
|
MNK1
|
72
|
4
|
|
MNK2
|
91
|
3
|
|
MSK1
|
86
|
8
|
|
MST2
|
69
|
6
|
|
MST4
|
114
|
3
|
|
NEK2a
|
90
|
5
|
|
NEK6
|
93
|
9
|
|
NEK7
|
114
|
1
|
|
p38 alpha MAPK
|
102
|
9
|
|
p38 beta MAPK
|
99
|
8
|
|
p38 delta MAPK
|
87
|
1
|
|
p38 gamma MAPK
|
79
|
8
|
|
PAK4
|
88
|
4
|
|
PAK5
|
82
|
3
|
|
PAK6
|
89
|
11
|
|
PDK1
|
93
|
11
|
|
PHK
|
103
|
8
|
|
PIM1
|
40
|
6
|
|
PIM2
|
55
|
2
|
|
PIM3
|
25
|
4
|
|
PKA
|
85
|
2
|
|
PKB alpha
|
81
|
7
|
|
PKB beta
|
103
|
8
|
|
PKC alpha
|
67
|
6
|
|
PKC zeta
|
75
|
10
|
|
PKD1
|
75
|
2
|
|
PLK1
|
99
|
7
|
|
PRAK
|
61
|
6
|
|
PRK2
|
35
|
1
|
|
ROCK 2
|
59
|
3
|
|
RSK1
|
97
|
5
|
|
RSK2
|
90
|
6
|
|
S6K1
|
84
|
9
|
|
SGK1
|
105
|
6
|
|
SmMLCK
|
80
|
7
|
|
Src
|
90
|
6
|
|
SRPK1
|
82
|
3
|
|
SYK
|
90
|
12
|
|
TBK1
|
95
|
5
|
|
YES1
|
97
|
0
|
Screen Conc:
20.00µM
| Kinase |
% Activity Remaining |
Standard Deviation |
|
AMPK
|
92
|
11
|
|
Aurora B
|
32
|
4
|
|
Aurora C
|
49
|
15
|
|
BRSK2
|
74
|
8
|
|
CAMK1
|
68
|
5
|
|
CAMKK beta
|
78
|
3
|
|
CDK2-Cyclin A
|
59
|
0
|
|
CHK1
|
64
|
13
|
|
CHK2
|
94
|
3
|
|
CK1 delta
|
62
|
4
|
|
CK2
|
54
|
1
|
|
CSK
|
102
|
8
|
|
DYRK1A
|
41
|
3
|
|
DYRK2
|
62
|
4
|
|
DYRK3
|
40
|
2
|
|
EF2K
|
86
|
12
|
|
EPH-A2
|
67
|
10
|
|
ERK1
|
98
|
12
|
|
ERK2
|
93
|
13
|
|
ERK8
|
21
|
2
|
|
FGF-R1
|
55
|
11
|
|
GSK3 beta
|
79
|
5
|
|
HIPK2
|
37
|
3
|
|
IKK beta
|
17
|
2
|
|
IKK epsilon
|
108
|
6
|
|
IRR
|
60
|
4
|
|
JNK1
|
84
|
14
|
|
JNK2
|
93
|
12
|
|
JNK3
|
84
|
4
|
|
Lck
|
81
|
6
|
|
MAPKAP-K2
|
60
|
3
|
|
MAPKAP-K3
|
87
|
9
|
|
MARK3
|
73
|
2
|
|
MELK
|
67
|
5
|
|
MKK1
|
71
|
0
|
|
MNK1
|
51
|
5
|
|
MNK2
|
65
|
12
|
|
MSK1
|
91
|
5
|
|
MST2
|
79
|
3
|
|
MST4
|
107
|
5
|
|
NEK2a
|
83
|
0
|
|
NEK6
|
82
|
10
|
|
NEK7
|
101
|
1
|
|
p38 alpha MAPK
|
80
|
10
|
|
p38 beta MAPK
|
93
|
11
|
|
p38 delta MAPK
|
88
|
7
|
|
p38 gamma MAPK
|
96
|
15
|
|
PAK4
|
97
|
4
|
|
PAK5
|
91
|
4
|
|
PAK6
|
98
|
12
|
|
PDK1
|
86
|
14
|
|
PHK
|
83
|
6
|
|
PIM1
|
25
|
5
|
|
PIM2
|
46
|
0
|
|
PIM3
|
12
|
1
|
|
PKA
|
68
|
13
|
|
PKB alpha
|
82
|
3
|
|
PKB beta
|
86
|
8
|
|
PKC alpha
|
57
|
12
|
|
PKC zeta
|
97
|
6
|
|
PKD1
|
46
|
3
|
|
PLK1
|
113
|
7
|
|
PRAK
|
57
|
1
|
|
PRK2
|
28
|
0
|
|
ROCK 2
|
48
|
10
|
|
RSK1
|
75
|
12
|
|
RSK2
|
93
|
8
|
|
S6K1
|
89
|
9
|
|
SGK1
|
81
|
3
|
|
SmMLCK
|
53
|
6
|
|
Src
|
87
|
0
|
|
SRPK1
|
78
|
9
|
|
SYK
|
88
|
4
|
|
TBK1
|
107
|
6
|
|
YES1
|
112
|
11
|
