Inhibitor | SB-431542  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
SB-431542   C22H16N4O3 · xH2O 384.39 301836-41-9 4521392 ALK Inman et al (2002) Mol.Pharmacol. 62 65

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 92 3
Aurora A 121 5
Aurora B 103 9
BRSK1 101 7
BRSK2 116 0
BTK 105 7
CAMK1 105 20
CAMKK beta 114 4
CDK2-Cyclin A 95 14
CHK1 107 0
CHK2 132 2
CK1 delta 71 4
CK2 106 3
CLK2 105 1
CSK 96 2
DAPK1 97 8
DYRK1A 98 3
DYRK2 103 6
DYRK3 109 26
EF2K 102 7
EPH-A2 103 6
EPH-A4 121 1
EPH-B2 115 11
EPH-B3 117 17
EPH-B4 116 16
ERK1 95 6
ERK2 112 9
ERK8 94 5
FGF-R1 111 7
GCK 117 8
GSK3 beta 95 4
HER4 95 1
HIPK1 107 13
HIPK2 119 7
HIPK3 105 13
IGF-1R 107 3
IKK beta 105 2
IKK epsilon 122 4
IR 99 17
IRAK4 95 3
IRR 101 8
JAK2 104 11
JNK1 108 1
JNK2 104 0
JNK3 111 20
Lck 115 9
LKB1 98 5
MAPKAP-K2 120 23
MAPKAP-K3 119 14
MARK1 129 12
MARK2 113 5
MARK3 100 8
MARK4 96 4
MEKK1 129 6
MELK 114 1
MINK1 120 17
MKK1 101 12
MLK1 94 6
MLK3 120 3
MNK1 118 1
MNK2 90 0
MSK1 120 13
MST2 105 4
MST4 93 6
NEK2a 109 10
NEK6 118 4
NUAK1 87 4
p38 alpha MAPK 91 2
p38 beta MAPK 114 27
p38 delta MAPK 91 7
p38 gamma MAPK 100 3
PAK2 103 7
PAK4 101 3
PAK5 116 5
PAK6 118 1
PDK1 111 7
PHK 106 6
PIM1 102 4
PIM2 95 1
PIM3 99 5
PKA 120 14
PKB alpha 100 1
PKB beta 101 2
PKC alpha 109 7
PKC zeta 102 8
PKD1 100 13
PLK1 112 14
PRAK 111 25
PRK2 105 3
RIPK2 67 6
ROCK 2 99 9
RSK1 119 9
RSK2 132 11
S6K1 104 5
SGK1 101 12
SmMLCK 99 2
Src 108 12
SRPK1 93 1
SYK 106 3
TAK1 99 26
TBK1 116 8
TrkA 131 21
TTK 104 14
VEGFR1 99 7
YES1 112 8
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 76 10
ASK1 114 5
Aurora A 92 14
Aurora B 87 3
BRSK1 91 12
BRSK2 103 5
BTK 84 6
CAMK1 113 9
CAMKK beta 62 6
CDK2-Cyclin A 126 3
CHK1 87 1
CHK2 128 3
CK1 delta 43 1
CK2 110 0
CLK2 79 6
CSK 97 11
DAPK1 83 7
DYRK1A 105 14
DYRK2 92 11
DYRK3 95 6
EF2K 103 11
EPH-A2 98 4
EPH-A4 97 1
EPH-B1 89 0
EPH-B2 86 12
EPH-B3 96 3
EPH-B4 88 4
ERK1 90 11
ERK2 97 5
ERK8 97 11
FGF-R1 83 1
GCK 41 1
GSK3 beta 83 10
HER4 88 6
HIPK1 96 6
HIPK2 96 4
HIPK3 104 2
IGF-1R 98 9
IKK beta 92 4
IKK epsilon 95 12
IR 92 6
IRAK4 67 4
IRR 86 4
JAK2 91 13
JNK1 95 10
JNK2 87 10
JNK3 90 6
Lck 94 5
LKB1 88 7
MAPKAP-K2 92 2
MAPKAP-K3 86 10
MARK1 91 14
MARK2 85 10
MARK3 109 11
MARK4 100 9
MEKK1 96 9
MELK 106 7
MINK1 73 2
MKK1 92 3
MKK2 83 0
MKK6 86 10
MLK1 95 10
MLK3 77 5
MNK1 109 2
MNK2 88 14
MSK1 90 0
MST2 89 8
MST4 96 2
NEK2a 102 12
NEK6 98 7
NUAK1 88 12
p38 alpha MAPK 75 3
p38 beta MAPK 74 8
p38 delta MAPK 72 4
p38 gamma MAPK 82 10
PAK2 93 3
PAK4 94 10
PAK5 89 12
PAK6 95 12
PDK1 104 9
PHK 96 2
PIM1 86 7
PIM2 89 7
PIM3 88 2
PKA 109 7
PKB alpha 86 3
PKB beta 88 10
PKC alpha 93 3
PKC zeta 101 8
PKD1 82 9
PLK1 88 2
PRAK 96 6
PRK2 98 6
RIPK2 31 0
ROCK 2 87 3
RSK1 90 1
RSK2 89 0
S6K1 107 3
SGK1 86 1
SmMLCK 85 2
Src 97 2
SRPK1 97 1
SYK 91 3
TAK1 83 15
TAO1 80 0
TBK1 103 10
TrkA 92 3
TTK 88 1
VEGFR1 95 12
YES1 92 7
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 103 4
ASK1 110 7
Aurora A 99 1
Aurora B 81 3
BRSK1 99 8
BRSK2 81 5
BTK 75 6
CAMK1 72 4
CAMKK beta 77 4
CDK2-Cyclin A 97 8
CHK1 103 4
CHK2 92 11
CK1 delta 16 1
CK2 103 7
CLK2 52 2
CSK 96 0
DAPK1 70 12
DYRK1A 103 8
DYRK2 93 0
DYRK3 110 15
EF2K 104 4
EPH-A2 94 9
EPH-A4 116 7
EPH-B1 98 8
EPH-B2 83 6
EPH-B3 88 10
EPH-B4 71 3
ERK1 94 2
ERK2 108 6
ERK8 99 3
FGF-R1 84 4
GCK 100 8
GSK3 beta 98 13
HER4 71 1
HIPK1 90 9
HIPK2 94 4
HIPK3 98 12
IGF-1R 106 11
IKK beta 101 5
IKK epsilon 96 2
IR 105 4
IRAK4 87 6
IRR 88 2
JAK2 87 1
JNK1 101 7
JNK2 106 8
JNK3 112 9
Lck 106 1
LKB1 90 4
MAPKAP-K2 97 7
MAPKAP-K3 84 7
MARK1 86 9
MARK2 90 6
MARK3 89 3
MARK4 109 2
MEKK1 88 2
MELK 90 3
MINK1 64 13
MKK1 87 4
MKK2 92 4
MKK6 94 2
MLK1 99 0
MLK3 50 3
MNK1 106 2
MNK2 122 2
MSK1 87 6
MST2 91 4
MST4 110 6
NEK2a 87 8
NEK6 102 10
NUAK1 72 1
p38 alpha MAPK 35 2
p38 beta MAPK 68 6
p38 delta MAPK 79 2
p38 gamma MAPK 85 1
PAK2 87 5
PAK4 79 1
PAK5 86 2
PAK6 91 5
PDK1 100 11
PHK 106 5
PIM1 86 8
PIM2 98 14
PIM3 90 0
PKA 109 3
PKB alpha 86 11
PKB beta 77 3
PKC alpha 96 1
PKC zeta 109 4
PKD1 57 10
PLK1 97 4
PRAK 100 4
PRK2 97 8
RIPK2
10
 1
ROCK 2 63 1
RSK1 96 10
RSK2 90 4
S6K1 90 6
SGK1 89 4
SmMLCK 76 8
Src 90 5
SRPK1 115 0
SYK 95 3
TAK1 82 1
TAO1 99 9
TBK1 87 12
TrkA 75 12
TTK 76 1
VEGFR1 95 13
YES1 86 2