Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

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Inhibitor Brutto MW Action Reference Reference 2
BI 2536   C28H39N7O3 521.65 PLK1 Steegmaier M. (2007) Current Biology 17 316-322
BI-78D3   C13H9N5O5S2 379.37 JNK Stebbins J.L. (2008) PNAS 105 16809-16813
BI-D-1870   C19H23N5O2F2 391.42 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38
BI605906 (BIX02514)   C17H22F2N4O3S2 432.51 IKKβ Clark K. (2011) Biochem. J. 434 93-104
Binimetinib   C17H15BrF2N4O3 441.20 MEK/RAF
BIO (6-Bromoindirubin-3'-oxime)   C16H10BrN3O2 356.20 GSK3 Tseng A.S. (2006) Chem. Biol. 13 957 Polychronopoulos P. (2004) J. Med. Chem. 47 935
BIRB-0796 (Doramapimod)   C31H37N5O3 527.66 p38 MAPK Regan J. (2002) J. Med. Chem 45 2994-3008
Blebbistatin   C18H16N2O2 292.30 myosin II Shu S. (2005) Proc. Natl. Acad. Sci. USA 102 1472 Kovacs M. (2004) J. Biol. Chem. 279 35557
BML-258 (SK1-I)   C17H28ClNO2 313.86 SphK1 Paugh S.W. (2008) Blood 112 1382-1391
BMS345541 (IKK Inhibitor III)   C14H17N5 255.32 IKBKB Du Z. (2012) J Interferon Cytokine Res. 368-77
Bosutinib   C26H29Cl2N5O3 530.45 src, Bcr-Ab1, PDGFR Vultur A. Mol Cancer Ther. (2008) 1185-94
Brigatinib   C29H39ClN7O2P 584.10 ALK; T790M; EGFR
BTX 161   C15H16N2O3 272.30 CK1a-PHM inhibitor
BX-320   C23H31BrN8O3 547.45 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874
BX-517   C15H14N4O2 282.30 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3814-3818
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825
BX-795   C23H26IN7O2S 591.47 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874
BX-912   C20H23BrN8O 471.35 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74
Cabozantinib   C28H24FN3O5 VEGFR2, PDGFR, KIT
Caffeine   C8H10N4O2 194.19 ATM Islam M.S. (1998) Proc. Natl. Acad. Sci. USA 95 6145-6150
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