Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

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Inhibitor Brutto MW Action Reference Reference 2
HA-1077, Dihydrochloride (Fasudil)   C14H17N3O2S • 2HCl 364.30 PKA Watanabe K. (2007) Nature Biotechnology 25 681 Swärd K. (2000) J. Physiol. 522 33
HA-1100 (Hydroxyfasudil)   C14H17N3O3S.HCl 343.83 ROCK S. Wolfrum (2004) Arterioscler. Thromb. Vasc. Biol. 24 1842
Harmaline   C13H14N2O 214.26 serotonin, monoamine oxidase Herraiz T. (2013) Drug Test. 1002/dta.1530.
Harmalol   C12H12N2O • HCl • 2H2O 272.73 serotonin, monoamine oxidase Riba J. (2012) Drug Test. 610-6.
Harmane   C12H10N2 182.22 serotonin, monoamine oxidase Smith KL. (2013) J Psychopharmacol. 162-70
Harmine   C13H12N2O 212.25 serotonin, monoamine oxidase Song Y. (2004) Biochem. Biophys. Res. Commun. 317 128–132
HG-10-102-01 LRRK2 Choi H.G. (2012) ACS Med. Chem. Lett.
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91
Hypothemycin C19H22O8 378.37 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086
Ibrutinib C25H24N6O2 440.50 BTK
IC261   C18H17NO4 311.30 CK1 Behrend L. (2000) Oncogene 19 5303 Mashhoon N. (2000) J. Biol. Chem. 275 20052
Icotinib   C22H21N3O4 391.40 EGFR
Idelalisib   C22H18FN7O 415.40 PI3K δ
IKK Inhibitor VII   C28H29N5OS 483.60 IKK Waelchli R. (2006) Bioorg. Med. Chem. Lett. 16 108
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373 Karin M. (2004) Nat. Rev. Drug Discov. 3 17
IKK-2 Inhibitor VIII   C21H24N4O2 364.40 IKK2 Murata T. (2004) Bioorg. Med. Chem. Lett. 14 4019
IKK-3 inhibitor IX   C22H19N3O5S2 469.50 IKK3 Bamborough P. (2006) Bioorg. Med. Chem. Lett. 16 6236
Imatinib   C29H31N7O 493.60 BCR-ABL, c-KIT, PDGFR Druker B. J. (2000) J. Clin. Invest. 105 3-7
IMD-0354   C15H8ClF6NO2 383.67 IKK2 Tanaka A, (2005) Blood 105 2324-2331
Infigratinib   C26H31Cl2N7O3 560.50 FGFR1-3
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