Inhibitor | BI-D-1870  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BI-D-1870   C19H23N5O2F2 391.42 501437-28-1 25023738 RSK Sapkota G.P. (2007) Biochem. J. 401 29–38

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
AMPK 101 3
Aurora B 53 5
BRSK2 91 4
BTK 92 7
CAMK1 93 5
CAMKK beta 98 12
CDK2-Cyclin A 88 5
CHK1 98 7
CHK2 97 9
CK1 delta 93 0
CK2 100 3
CSK 91 1
DYRK1A 90 3
DYRK2 100 4
DYRK3 100 11
EF2K 107 3
EPH-A2 105 14
EPH-B3 118 13
ERK1 96 13
ERK2 95 2
ERK8 94 1
FGF-R1 131 54
GSK3 beta 84 0
HIPK2 97 9
IGF-1R 71 6
IKK beta 95 5
IKK epsilon 107 1
IR 96 6
IRR 79 17
JNK1 98 4
JNK2 93 2
JNK3 95 5
Lck 89 2
MAPKAP-K2 92 6
MAPKAP-K3 57 4
MARK3 101 0
MELK 85 1
MKK1 103 4
MNK1 98 6
MNK2 121 4
MSK1 95 5
MST2 65 8
MST4 95 8
NEK2a 93 4
NEK6 88 4
NEK7 107 8
p38 alpha MAPK 89 3
p38 beta MAPK 89 0
p38 delta MAPK 89 0
p38 gamma MAPK 99 9
PAK4 85 3
PAK5 91 5
PAK6 88 0
PDK1 99 4
PHK 77 2
PIM1 104 0
PIM2 98 5
PIM3 79 10
PKA 91 4
PKB alpha 110 5
PKB beta 100 4
PKC alpha 103 5
PKC zeta 84 9
PKD1 89 5
PLK1 33 1
PRAK 84 8
PRK2 80 5
ROCK 2 104 1
RSK1 14 2
RSK2 32 2
S6K1 83 3
SGK1 98 3
SmMLCK 106 4
Src 98 1
SRPK1 97 2
SYK 100 10
TBK1 101 2
VEGFR1 88 2
YES1 100 6
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 107 6
Aurora B 22 4
Aurora C 76 4
BRSK2 78 9
BTK 96 9
CAMK1 103 8
CAMKK alpha 92 8
CAMKK beta 72 12
CDK2-Cyclin A 84 0
CHK1 73 0
CHK2 96 2
CK1 delta 81 5
CK2 97 4
CSK 98 8
DYRK1A 95 9
DYRK2 90 0
DYRK3 90 3
EF2K 87 0
EPH-A2 91 3
EPH-B3 109 6
ERK1 114 2
ERK2 84 1
ERK8 81 6
FGF-R1 79 11
GSK3 beta 77 5
HIPK2 102 6
HIPK3 104 5
IGF-1R 79 3
IKK beta 105 10
IKK epsilon 88 5
IR 106 4
IRR 75 5
JNK1 88 6
JNK2 115 12
JNK3 96 10
Lck 85 0
MAPKAP-K2 89 14
MAPKAP-K3 108 12
MARK3 78 5
MELK 40 5
MKK1 98 4
MNK1 87 9
MNK2 96 11
MSK1 124 5
MST2 41 3
MST4 77 8
NEK2a 97 10
NEK6 114 8
NEK7 108 0
p38 alpha MAPK 87 12
p38 beta MAPK 100 4
p38 delta MAPK 105 8
p38 gamma MAPK 111 3
PAK4 81 11
PAK5 89 5
PAK6 101 9
PDK1 94 7
PHK 114 13
PIM1 75 1
PIM2 100 8
PIM3 65 3
PKA 88 8
PKB alpha 97 1
PKB beta 101 14
PKC alpha 90 9
PKC zeta 80 1
PKD1 62 11
PLK1
5
 1
PRAK 88 14
PRK2 97 5
ROCK 2 83 13
RSK1
1
 0
RSK2
2
 5
S6K1 119 8
SGK1 111 7
SmMLCK 107 4
Src 96 3
SRPK1 94 7
SYK 94 18
TBK1 97 1
VEGFR1 59 2
YES1 86 0
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 90 3
AMPK 55 2
ASK1 102 3
Aurora A 24 0
Aurora B
7
 1
BRK 95 10
BRSK1 86 0
BRSK2 76 5
BTK 95 7
CAMK1 78 11
CAMKK beta 40 7
CDK2-Cyclin A 15 2
CHK1 108 11
CHK2 84 5
CK1 delta 63 1
CK2 92 1
CLK2 26 7
CSK 76 0
DAPK1 83 2
DYRK1A 60 4
DYRK2 85 1
DYRK3 80 8
EF2K 90 6
EPH-A2 98 12
EPH-A4 105 5
EPH-B1 86 1
EPH-B2 93 4
EPH-B3 109 4
EPH-B4 94 6
ERK1 94 5
ERK2 74 5
ERK8 39 8
FGF-R1 108 13
GCK 37 3
GSK3 beta 35 3
HER4 89 4
HIPK1 90 5
HIPK2 61 1
HIPK3 113 2
IGF-1R 57 3
IKK beta 101 4
IKK epsilon 91 0
IR 88 0
IRAK4 31 5
IRR 43 7
JAK2 66 3
JNK1 104 0
JNK2 83 0
JNK3 99 3
Lck 63 7
LKB1 92 3
MAPKAP-K2 91 5
MAPKAP-K3 89 1
MARK1 85 2
MARK2 51 4
MARK3 31 5
MARK4 77 7
MEKK1 108 13
MELK
9
 0
MINK1
7
 3
MKK1 74 3
MKK2 64 4
MKK6 108 5
MLK1 16 4
MLK3
8
 4
MNK1 90 4
MNK2 95 3
MPSK1 105 2
MSK1 73 0
MST2
7
 0
MST4 25 2
NEK2a 59 4
NEK6 98 8
NUAK1 44 4
p38 alpha MAPK 91 0
p38 beta MAPK 107 4
p38 delta MAPK 93 2
p38 gamma MAPK 98 11
PAK2 88 0
PAK4 58 0
PAK5 73 1
PAK6 70 4
PDK1 84 7
PHK 108 3
PIM1 43 1
PIM2 99 12
PIM3 19 0
PKA 83 7
PKB alpha 102 7
PKB beta 103 10
PKC alpha 96 14
PKC gamma 77 7
PKC zeta 93 0
PKD1 61 0
PLK1
6
 2
PRAK 88 6
PRK2 74 2
RIPK2 92 0
ROCK 2 76 0
RSK1
0
 0
RSK2
4
 1
S6K1 41 3
SGK1 83 0
SmMLCK 73 6
Src 72 11
SRPK1 90 4
STK33 62 0
SYK 87 8
TAK1 49 8
TAO1 18 2
TBK1 95 10
TIE2 91 4
TrkA 60 1
TTK 63 2
VEGFR1 19 0
YES1 82 15
ZAP70 112 8
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 40 2
AMPK 67 1
ASK1 93 3
Aurora A
4
 0
Aurora B
4
 0
BRK 87 5
BRSK1 43 0
BRSK2 21 1
BTK 45 6
CAMK1 60 9
CAMKK beta
9
 0
CDK2-Cyclin A 30 6
CHK1 74 6
CHK2 65 2
CK1 delta 32 0
CK2 99 3
CLK2 11 11
CSK 80 12
DAPK1 74 13
DYRK1A 46 6
DYRK2 44 4
DYRK3 29 1
EF2K 96 0
EPH-A2 52 0
EPH-A4 65 3
EPH-B1 51 2
EPH-B2 48 4
EPH-B3 43 1
EPH-B4 106 8
ERK1 42 1
ERK2 73 0
ERK8 54 8
FGF-R1 13 1
GCK
8
 2
GSK3 beta 21 3
HER4 59 0
HIPK1 64 1
HIPK2 15 1
HIPK3 72 4
IGF-1R 14 3
IKK beta 74 3
IKK epsilon 31 3
IR 13 2
IRAK4 63 3
IRR 20 1
JAK2 12 0
JNK1 83 8
JNK2 71 4
JNK3 71 1
Lck 34 1
LKB1 49 2
MAPKAP-K2 89 8
MAPKAP-K3 92 3
MARK1 33 5
MARK2 38 0
MARK3 36 2
MARK4 27 0
MEKK1 86 6
MELK
3
 0
MINK1
8
 5
MKK1 48 1
MKK2 25 9
MKK6 80 1
MLK1 12 6
MLK3
4
 0
MNK1 76 0
MNK2 86 4
MPSK1 69 2
MSK1 70 7
MST2 12 1
MST4
3
 0
NEK2a 80 0
NEK6 92 0
NUAK1
9
 0
p38 alpha MAPK 76 11
p38 beta MAPK 90 9
p38 delta MAPK 88 9
p38 gamma MAPK 89 4
PAK2 74 8
PAK4 12 0
PAK5 29 0
PAK6 35 0
PDK1 78 6
PHK 99 4
PIM1
6
 0
PIM2 61 4
PIM3
3
 0
PKA 65 5
PKB alpha 94 8
PKB beta 95 7
PKC alpha 36 6
PKC gamma 44 4
PKC zeta 86 6
PKD1 53 5
PLK1
2
 0
PRAK 73 4
PRK2 67 6
RIPK2 73 1
ROCK 2 69 3
RSK1
2
 0
RSK2
1
 0
S6K1 54 1
SGK1 67 11
SmMLCK 46 6
Src 59 3
SRPK1 80 9
STK33 20 1
SYK 36 5
TAK1
9
 2
TAO1
8
 2
TBK1 28 5
TIE2 15 3
TrkA
8
 2
TTK 30 8
VEGFR1
3
 0
YES1 23 6
ZAP70 85 4