Inhibitor | BI605906 (BIX02514)  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	92	12
AMPK	92	15
ASK1	94	8
Aurora A	106	9
Aurora B	98	10
BRK	99	2
BRSK1	96	4
BRSK2	89	8
BTK	92	9
CAMK1	95	7
CAMKK beta	93	12
CDK2-Cyclin A	92	0
CHK1	91	11
CHK2	96	3
CK1 delta	78	0
CK2	86	5
CLK2	100	4
CSK	98	13
DAPK1	97	13
DYRK1A	100	2
DYRK2	96	1
DYRK3	87	4
EF2K	96	9
EIF2AK3	104	11
EPH-A2	89	3
EPH-A4	97	3
EPH-B1	96	5
EPH-B2	97	4
EPH-B3	101	6
EPH-B4	95	1
ERK1	78	3
ERK2	90	5
ERK8	84	9
FGF-R1	98	7
GCK	81	4
GSK3 beta	96	7
HER4	97	2
HIPK1	97	7
HIPK2	91	4
HIPK3	96	3
IGF-1R	92	1
IKK beta	33	0
IKK epsilon	75	3
IR	97	4
IRAK1	80	1
IRAK4	98	7
IRR	84	1
JAK2	83	0
JNK1	78	15
JNK2	95	1
JNK3	118	7
Lck	108	10
LKB1	92	4
MAPKAP-K2	109	9
MAPKAP-K3	85	6
MARK1	84	3
MARK2	91	11
MARK3	94	7
MARK4	81	11
MEKK1	115	1
MELK	106	5
MINK1	85	12
MKK1	110	11
MKK2	93	6
MKK6	87	8
MLK1	95	1
MLK3	96	1
MNK1	88	6
MNK2	97	4
MPSK1	94	0
MSK1	115	14
MST2	84	11
MST4	92	11
NEK2a	98	10
NEK6	104	1
NUAK1	81	10
OSR1	98	9
p38 alpha MAPK	91	6
p38 beta MAPK	96	13
p38 delta MAPK	92	4
p38 gamma MAPK	92	5
PAK2	96	4
PAK4	93	10
PAK5	92	7
PAK6	93	3
PDK1	85	12
PHK	101	3
PIM1	96	11
PIM2	87	4
PIM3	85	3
PKA	84	7
PKB alpha	89	5
PKB beta	100	1
PKC alpha	94	3
PKC gamma	101	8
PKC zeta	87	5
PKD1	90	1
PLK1	94	4
PRAK	101	6
PRK2	98	3
RIPK2	96	7
ROCK 2	100	4
RSK1	112	6
RSK2	104	8
S6K1	85	5
SGK1	89	5
SmMLCK	88	5
Src	81	4
SRPK1	95	13
STK33	86	0
SYK	86	11
TAK1	100	1
TAO1	89	4
TBK1	100	21
TIE2	87	1
TLK1	94	10
TrkA	109	2
TTK	96	11
VEGFR1	81	3
YES1	108	6
ZAP70	102	8

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	102	10
AMPK	94	8
ASK1	92	4
Aurora A	112	6
Aurora B	96	4
BRK	103	2
BRSK1	105	7
BRSK2	110	12
BTK	108	1
CAMK1	98	6
CAMKK beta	89	13
CDK2-Cyclin A	88	6
CHK1	101	2
CHK2	104	2
CK1 delta	80	2
CK2	84	14
CLK2	102	1
CSK	112	6
DAPK1	86	9
DYRK1A	100	6
DYRK2	98	11
DYRK3	82	1
EF2K	105	7
EIF2AK3	109	4
EPH-A2	106	6
EPH-A4	110	5
EPH-B1	114	8
EPH-B2	102	7
EPH-B3	117	8
EPH-B4	100	10
ERK1	108	8
ERK2	105	2
ERK8	102	7
FGF-R1	82	2
GCK	87	3
GSK3 beta	108	5
HER4	95	8
HIPK1	106	10
HIPK2	100	13
HIPK3	96	7
IGF-1R	62	7
IKK beta	16	2
IKK epsilon	98	14
IR	80	1
IRAK1	84	9
IRAK4	96	6
IRR	57	1
JAK2	93	13
JNK1	85	5
JNK2	109	2
JNK3	94	9
Lck	104	2
LKB1	106	5
MAPKAP-K2	101	18
MAPKAP-K3	92	9
MARK1	94	15
MARK2	85	2
MARK3	96	8
MARK4	108	12
MEKK1	126	4
MELK	104	0
MINK1	91	0
MKK1	120	8
MKK2	97	13
MKK6	104	2
MLK1	98	8
MLK3	114	12
MNK1	76	8
MNK2	109	3
MPSK1	113	6
MSK1	102	4
MST2	90	1
MST4	99	3
NEK2a	97	3
NEK6	130	0
NUAK1	93	14
OSR1	98	4
p38 alpha MAPK	83	0
p38 beta MAPK	93	4
p38 delta MAPK	105	2
p38 gamma MAPK	85	0
PAK2	105	5
PAK4	90	6
PAK5	102	8
PAK6	113	2
PDK1	81	4
PHK	105	4
PIM1	82	4
PIM2	96	2
PIM3	74	9
PKA	88	3
PKB alpha	85	14
PKB beta	120	10
PKC alpha	87	2
PKC gamma	130	7
PKC zeta	87	5
PKD1	123	2
PLK1	103	2
PRAK	75	16
PRK2	87	5
RIPK2	76	2
ROCK 2	86	10
RSK1	113	12
RSK2	113	10
S6K1	99	5
SGK1	101	10
SmMLCK	86	6
Src	106	11
SRPK1	102	1
STK33	98	6
SYK	108	3
TAK1	109	8
TAO1	124	13
TBK1	103	15
TIE2	108	2
TLK1	91	13
TrkA	115	11
TTK	99	7
VEGFR1	88	0
YES1	89	12
ZAP70	103	1