Inhibitor | BI-78D3  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	83	8
ASK1	100	4
Aurora A	88	0
Aurora B	82	1
BRSK1	99	11
BRSK2	90	5
BTK	71	4
CAMK1	80	4
CAMKK beta	84	7
CDK2-Cyclin A	82	5
CHK1	102	14
CHK2	109	3
CK1 delta	99	2
CK2	118	4
CLK2	96	6
CSK	101	11
DAPK1	101	1
DYRK1A	105	5
DYRK2	86	1
DYRK3	105	1
EF2K	109	12
EPH-A2	88	15
EPH-A4	99	9
EPH-B1	97	6
EPH-B2	103	6
EPH-B3	91	12
EPH-B4	97	2
ERK1	106	4
ERK2	96	7
ERK8	105	2
FGF-R1	91	3
GCK	97	9
GSK3 beta	93	1
HER4	78	4
HIPK1	86	10
HIPK2	97	8
HIPK3	91	4
IGF-1R	88	13
IKK beta	97	5
IKK epsilon	93	4
IR	83	12
IRAK4	92	1
IRR	98	12
JAK2	89	14
JNK1	92	6
JNK2	105	3
JNK3	108	13
Lck	107	4
LKB1	85	3
MAPKAP-K2	93	4
MAPKAP-K3	89	2
MARK1	88	8
MARK2	87	4
MARK3	98	6
MARK4	86	1
MEKK1	120	0
MELK	121	7
MINK1	94	10
MKK1	101	12
MKK2	95	1
MKK6	103	6
MLK1	59	1
MLK3	90	2
MNK1	106	15
MNK2	100	2
MSK1	90	1
MST2	97	7
MST4	105	8
NEK2a	74	5
NEK6	111	14
NUAK1	80	4
p38 alpha MAPK	97	8
p38 beta MAPK	99	0
p38 delta MAPK	93	1
p38 gamma MAPK	85	9
PAK2	106	6
PAK4	102	10
PAK5	81	5
PAK6	79	5
PDK1	97	4
PHK	117	4
PIM1	89	5
PIM2	99	6
PIM3	115	5
PKA	98	3
PKB alpha	99	1
PKB beta	90	8
PKC alpha	98	0
PKC zeta	107	8
PKD1	89	3
PLK1	91	1
PRAK	94	0
PRK2	92	9
RIPK2	93	0
ROCK 2	95	6
RSK1	91	2
RSK2	89	2
S6K1	101	7
SGK1	102	0
SmMLCK	88	8
Src	122	4
SRPK1	97	0
SYK	92	7
TAK1	93	6
TAO1	100	9
TBK1	82	2
TrkA	103	7
TTK	92	10
VEGFR1	77	9
YES1	92	1

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	71	3
ASK1	95	3
Aurora A	71	3
Aurora B	38	4
BRSK1	86	11
BRSK2	71	2
BTK	23	4
CAMK1	50	2
CAMKK beta	83	11
CDK2-Cyclin A	84	7
CHK1	92	10
CHK2	97	8
CK1 delta	101	4
CK2	108	2
CLK2	92	2
CSK	85	2
DAPK1	75	5
DYRK1A	97	1
DYRK2	75	3
DYRK3	89	10
EF2K	89	6
EPH-A2	74	9
EPH-A4	102	4
EPH-B1	99	5
EPH-B2	119	2
EPH-B3	91	8
EPH-B4	91	2
ERK1	123	8
ERK2	94	14
ERK8	113	3
FGF-R1	88	4
GCK	84	3
GSK3 beta	87	4
HER4	46	13
HIPK1	86	10
HIPK2	100	4
HIPK3	93	4
IGF-1R	107	7
IKK beta	82	0
IKK epsilon	73	1
IR	102	1
IRAK4	81	9
IRR	82	5
JAK2	94	4
JNK1	93	2
JNK2	97	3
JNK3	95	3
Lck	93	2
LKB1	74	7
MAPKAP-K2	94	9
MAPKAP-K3	73	5
MARK1	94	0
MARK2	72	8
MARK3	84	2
MARK4	72	1
MEKK1	96	3
MELK	86	5
MINK1	68	6
MKK1	84	15
MKK2	80	11
MKK6	90	1
MLK1	51	0
MLK3	89	6
MNK1	98	10
MNK2	95	3
MSK1	82	2
MST2	80	3
MST4	82	5
NEK2a	25	6
NEK6	93	2
NUAK1	85	14
p38 alpha MAPK	81	7
p38 beta MAPK	89	2
p38 delta MAPK	75	0
p38 gamma MAPK	87	5
PAK2	90	8
PAK4	90	10
PAK5	79	7
PAK6	74	4
PDK1	90	4
PHK	107	1
PIM1	68	2
PIM2	100	14
PIM3	93	8
PKA	95	3
PKB alpha	92	1
PKB beta	46	5
PKC alpha	98	5
PKC zeta	103	3
PKD1	77	5
PLK1	73	1
PRAK	87	1
PRK2	86	6
RIPK2	92	12
ROCK 2	88	1
RSK1	76	11
RSK2	53	5
S6K1	92	4
SGK1	93	2
SmMLCK	92	9
Src	55	8
SRPK1	85	5
SYK	103	13
TAK1	90	2
TAO1	85	2
TBK1	75	1
TrkA	77	8
TTK	84	6
VEGFR1	38	1
YES1	78	8

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	91	11
Aurora B	2	0
BRSK2	70	8
BTK	2	0
CAMK1	12	3
CAMKK beta	80	1
CDK2-Cyclin A	84	8
CHK1	100	3
CHK2	87	0
CK1 delta	119	5
CK2	106	4
CSK	91	7
DYRK1A	98	5
DYRK2	76	3
DYRK3	64	3
EF2K	83	6
EPH-A2	110	16
EPH-B3	62	4
ERK1	83	5
ERK2	98	0
ERK8	148	26
FGF-R1	116	13
GSK3 beta	84	4
HIPK2	118	1
IGF-1R	91	1
IKK beta	27	2
IKK epsilon	79	0
IR	119	9
IRR	82	5
JNK1	95	1
JNK2	87	0
Lck	93	2
MAPKAP-K2	82	9
MARK3	83	5
MELK	78	14
MKK1	90	8
MNK1	96	0
MNK2	90	0
MSK1	85	0
MST2	80	3
MST4	34	4
NEK2a	1	0
NEK6	24	2
p38 alpha MAPK	94	4
p38 beta MAPK	110	2
p38 delta MAPK	104	3
p38 gamma MAPK	110	2
PAK4	120	1
PAK5	101	5
PAK6	91	0
PDK1	125	7
PHK	105	2
PIM1	63	0
PIM2	123	11
PIM3	78	1
PKA	98	4
PKB alpha	98	10
PKB beta	1	0
PKC alpha	49	2
PKC zeta	65	2
PKD1	63	2
PLK1	3	0
PRAK	80	4
PRK2	95	3
ROCK 2	91	2
RSK1	69	12
RSK2	24	2
S6K1	18	0
SGK1	116	17
SmMLCK	91	11
Src	82	7
SRPK1	105	8
SYK	95	3
TBK1	73	9
VEGFR1	38	1
YES1	63	4