Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Inhibitor Brutto MW Action Reference Reference 2
ER-27319   C20H22N2O5 370.40 SYK Moriya K. (1997) Proc. Natl. Acad. Sci. USA 94 12539-12544
Erdafitinib   C25H30N6O2 446.50 FGFRs
Erlotinib   C22H23N3O4 EGFR
ETP 46464   C30H22N4O2 470.52 ATRi Toledo L.I. (2011) Nature structural and molecular biology 18 721-727
Everolimus   C53H83NO14 mTOR
Fasudil   C14H17N3O2S 291.10 ROCK1/2
Febuxostat (TMX-67, Adenuric, Uloric)   C16H16N2O3S 316.37 Xanthine oxidase (XO) Gaffo AL. (2010 ) Core Evid. 4 25-36 Grabowski B (2010) Br J Clin Pharmacol. 70 57-64
Fedratinib   C27H36N6O3S 524.70 JAK3; FLT3; BRD4
Filgotinib   C21H23N5O3S 425.50 JAK1
Flumatinib   C29H29F3N8O 562.60 Bcr-ABL; PDGFR
FMK (Caspase Inhibitor I)   C22H30FN3O7 467.50 Caspase Martin U. (2007) Apoptosis 12 525 Misaghi S. (2004) Chem. Biol. 11 1677
Fostamatinib   C23H26FN6O9P 580.46
Fostamatinib   C23H26FN6O9P 580.50 SYK
Fruquintinib   C21H19N3O5 393.40 VEGFR
Furmonertinib   C28H31F3N8O2 568.60 EGFR; T790M
Futibatinib   C22H22N6O3 418.40 FGFR2
GDC-0941   C23H29N7O3S2Cl2 586.57 PI3K Folkes AJ. (2008) J Med Chem. 5522-32
Gefitinib   C22H24ClFN4O3 EGFR
Genentech LRRK2 inhibitor compound 18 (GNE-7915)   C19H21F4N5O3 443.40 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33