Kinase Profiling Inhibitor Database

This is a searchable database of specificities of 367 commonly used signal transduction inhibitors. These results have been provided by the International Centre for Kinase profiling within the MRC Protein Phosphorylation Unit at the University of Dundee.

We strongly recommend undertaking kinase profiling of any kinase inhibitor to be used in a biological experiment. It is essential to have a good feel for the specificity of the kinase inhibitor you are working with in order to be able to properly interpret your data.

If you have additional kinase inhibitors that you would like the International Centre for Kinase profiling team to profile for you please contact us here for further details.

If you have any feedback or suggestions on how to improve this resource we welcome your input. Pass on your ideas to us here.

Download CSV
Download CSV
Inhibitor Brutto MW Action Reference Reference 2
Almonertinib   C30H35N7O2 525.60 T790M; EGFR
Alpelisib   C19H22F3N5O2S 441.50 PI3Kα
Alsterpaullone   C16H11N3O3 293.30 GSK3b, CDK5/p25, CDK1/cyclin B Leost M. (2000) Eur. J. Biochem. 267 5983 Schultz C. (1999) J. Med. Chem. 42 2909
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244
Amivantamab EGFR/MET
Amlexanox   C16H14N2O4 298.29 TBK1, IKKe
Apatinib   C24H23N5O 397.50 VEGFR2; KIT; Src
ARA014418   C12H12N4O4S 308.30 GSK3 Noble W. (2005) Proc. Natl. Acad. Sci. USA 102 6990 Bhat R. (2003) J. Biol. Chem. 278 45937
AS601245 (JNK Inhibitor V)   C20H16N6S 372.50 JNK Gaillard P. (2005) J. Med. Chem. 48 4596 Carboni S. (2005) J. Neurochem. 92 1054
Asciminib   C20H18ClF2N5O3 449.80 Bcr-ABL
Avapritinib   C26H27FN10 498.60 mutants KIT; PDGFR
AX 20017   C13H16N2O2S 264.34 PknG Walburger A (2004) Science 304 1800-1804
Axitinib   C22H18N4OS VEGFRs, PDGFRB, c-KIT
AZD8055   C25H31N5O4 465.50 mTOR C1, mTOR C2 Chresta C.M. (2010) Cancer Res. 70 288-298 Sini P. (2010) Autophagy 6(4)
Baricitinib   C16H17N7O2S JAKs
BAY 61-3606 C20H18N6O3 · xHCl · yH2O 390.40 Syk Yamamoto N. (2003) J. Pharmacol. Exp. Ther. 306 1174-1181
Bay 65-1942   C22H26ClN3O4 431.91 IKKb Ziegelbauer K. (2005) British Journal of Pharmacology 145 178-192 (compound A) Moss N.C. (2007) Am J Physiol Heart Circ Physiol 293 H2248-53
BAY-11-7082   C10H9NO2S 207.20 NFKBIA Kamthong P.J. (2001) Biochem. J. 356 Izban K.F. (2000) Hum. Pathol. 31 1482
BAY-3827   C27H25FN6O 468.54 AMPK inhibitor C.Lemos Cellular Oncology (2021), 44, 581-594
Download CSV
Download CSV