Inhibitor | BX-517  

Screen Conc: 0.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	62	0
BRSK2	59	5
BTK	95	4
CAMK1	104	12
CAMKK beta	101	5
CDK2-Cyclin A	102	3
CHK1	89	8
CHK2	32	7
CK1 delta	94	3
CK2	92	7
CSK	114	32
DYRK1A	110	18
DYRK2	88	5
DYRK3	83	3
EF2K	99	29
EPH-A2	97	1
EPH-B3	114	10
ERK1	97	3
ERK2	108	11
ERK8	85	7
FGF-R1	96	8
GSK3 beta	97	21
HIPK2	89	6
IGF-1R	71	59
IKK beta	76	5
IKK epsilon	85	6
IR	109	20
IRR	91	1
JNK1	114	2
JNK2	159	63
Lck	97	10
MAPKAP-K2	98	11
MARK3	93	18
MELK	86	4
MKK1	87	0
MNK1	92	9
MNK2	93	2
MSK1	83	1
MST2	83	5
MST4	87	11
NEK2a	92	14
NEK6	86	7
p38 alpha MAPK	87	4
p38 beta MAPK	104	15
p38 delta MAPK	96	10
p38 gamma MAPK	89	12
PAK4	80	7
PAK5	84	13
PAK6	97	10
PDK1	94	6
PHK	97	10
PIM1	97	12
PIM2	97	23
PIM3	96	13
PKA	92	1
PKB alpha	85	1
PKB beta	79	7
PKC alpha	102	9
PKC zeta	78	8
PKD1	81	2
PLK1	86	18
PRAK	100	16
PRK2	67	3
ROCK 2	88	10
RSK1	89	3
RSK2	82	4
S6K1	95	16
SGK1	98	16
SmMLCK	90	0
Src	84	0
SRPK1	98	14
SYK	100	7
TBK1	99	4
VEGFR1	95	7
YES1	77	8

Screen Conc: 0.01µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	25	4
BRSK2	21	3
BTK	85	4
CAMK1	116	15
CAMKK beta	90	5
CDK2-Cyclin A	87	3
CHK1	66	22
CHK2	7	7
CK1 delta	94	0
CK2	91	10
CSK	97	9
DYRK1A	91	13
DYRK2	59	0
DYRK3	74	4
EF2K	101	8
EPH-A2	101	15
EPH-B3	99	2
ERK1	89	8
ERK2	95	8
ERK8	49	1
FGF-R1	61	4
GSK3 beta	92	7
HIPK2	82	3
IGF-1R	63	34
IKK beta	74	0
IKK epsilon	84	7
IR	102	7
IRR	75	7
JNK1	117	18
JNK2	123	9
Lck	95	15
MAPKAP-K2	86	1
MARK3	61	2
MELK	47	1
MKK1	33	1
MNK1	87	2
MNK2	86	6
MSK1	87	0
MST2	36	2
MST4	80	5
NEK2a	92	2
NEK6	84	6
p38 alpha MAPK	86	1
p38 beta MAPK	100	3
p38 delta MAPK	89	6
p38 gamma MAPK	87	2
PAK4	85	11
PAK5	83	24
PAK6	102	0
PDK1	62	3
PHK	66	5
PIM1	98	2
PIM2	92	4
PIM3	73	3
PKA	87	8
PKB alpha	76	6
PKB beta	82	11
PKC alpha	113	1
PKC zeta	84	2
PKD1	55	2
PLK1	82	8
PRAK	90	4
PRK2	61	4
ROCK 2	90	3
RSK1	75	13
RSK2	65	2
S6K1	91	10
SGK1	86	4
SmMLCK	89	5
Src	79	4
SRPK1	96	2
SYK	104	5
TBK1	83	5
VEGFR1	50	1
YES1	60	9

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	7	1
BRSK2	12	0
BTK	93	5
CAMK1	103	17
CAMKK beta	60	12
CDK2-Cyclin A	85	13
CHK1	21	2
CHK2	0	5
CK1 delta	89	0
CK2	86	0
CSK	102	10
DYRK1A	67	7
DYRK2	18	3
DYRK3	33	1
EF2K	106	1
EPH-A2	87	2
EPH-B3	101	2
ERK1	82	15
ERK2	79	5
ERK8	7	2
FGF-R1	18	2
GSK3 beta	49	14
HIPK2	51	2
IGF-1R	94	2
IKK beta	84	20
IKK epsilon	69	0
IR	110	3
IRR	47	10
JNK1	106	1
JNK2	118	12
Lck	64	4
MAPKAP-K2	94	33
MARK3	14	3
MELK	9	0
MKK1	7	0
MNK1	82	1
MNK2	78	8
MSK1	80	6
MST2	10	2
MST4	56	20
NEK2a	86	14
NEK6	82	7
p38 alpha MAPK	84	11
p38 beta MAPK	105	3
p38 delta MAPK	86	9
p38 gamma MAPK	82	1
PAK4	76	8
PAK5	78	7
PAK6	88	9
PDK1	20	5
PHK	18	1
PIM1	69	0
PIM2	65	14
PIM3	25	4
PKA	81	13
PKB alpha	80	21
PKB beta	84	22
PKC alpha	107	15
PKC zeta	83	0
PKD1	27	7
PLK1	72	8
PRAK	94	12
PRK2	36	5
ROCK 2	84	4
RSK1	24	2
RSK2	19	1
S6K1	83	0
SGK1	58	9
SmMLCK	65	6
Src	71	4
SRPK1	93	9
SYK	97	16
TBK1	43	3
VEGFR1	13	2
YES1	42	2