Inhibitor | BX-795  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-795   C23H26IN7O2S 591.47 702675-74-9 10077147 PDK1 Feldman R.I. (2005) Journal of Biological Chemistry 280 19867-19874

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
AMPK 51 0
Aurora B 17 1
Aurora C 26 3
BRSK2 91 3
BTK 107 4
CAMK1 86 10
CAMKK alpha 85 13
CAMKK beta 82 5
CDK2-Cyclin A 56 6
CHK1 83 5
CHK2 90 0
CK1 delta 78 4
CK2 93 10
CSK 113 11
DYRK1A 94 7
DYRK2 104 9
DYRK3 85 9
EF2K 97 5
EPH-A2 109 7
EPH-B3 110 6
ERK1 81 8
ERK2 88 3
ERK8 40 3
FGF-R1 84 11
GSK3 beta 82 14
HIPK2 95 11
HIPK3 94 1
IGF-1R 108 8
IKK beta 108 2
IKK epsilon 40 6
IR 85 13
IRR 89 0
JNK1 103 6
JNK2 100 12
JNK3 93 3
Lck 97 3
MAPKAP-K2 107 8
MAPKAP-K3 102 6
MARK3 12 0
MELK 95 3
MKK1 49 3
MNK1 80 7
MNK2 46 3
MSK1 88 0
MST2 95 2
MST4 126 11
NEK2a 91 6
NEK6 95 3
NEK7 110 7
p38 alpha MAPK 85 2
p38 beta MAPK 93 13
p38 delta MAPK 90 5
p38 gamma MAPK 94 2
PAK4 90 14
PAK5 97 2
PAK6 91 2
PDK1 29 2
PHK 94 12
PIM1 102 7
PIM2 108 2
PIM3 95 7
PKA 101 1
PKB alpha 90 14
PKB beta 112 6
PKC alpha 105 1
PKC zeta 95 11
PKD1 83 3
PLK1 94 6
PRAK 96 5
PRK2 79 4
ROCK 2 90 6
RSK1 100 6
RSK2 100 9
S6K1 100 3
SGK1 86 6
SmMLCK 110 5
Src 90 4
SRPK1 98 11
SYK 89 9
TBK1 25 2
VEGFR1 75 10
YES1 90 6
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 23 2
Aurora A 20 2
Aurora B
5
 0
BRSK1 77 21
BRSK2 78 5
BTK 100 15
CAMK1 107 10
CAMKK beta 30 1
CDK2-Cyclin A 19 6
CHK1 57 5
CHK2 74 5
CK1 delta 106 21
CK2 99 9
CLK2 65 8
CSK 91 6
DAPK1 87 4
DYRK1A 91 2
DYRK2 81 5
DYRK3 82 5
EF2K 113 3
EPH-A2 79 12
EPH-A4 100 9
EPH-B2 112 5
EPH-B3 100 2
EPH-B4 94 5
ERK1 95 13
ERK2 91 3
ERK8 72 58
FGF-R1 46 3
GCK 21 5
GSK3 beta 71 4
HER4 98 1
HIPK1 105 3
HIPK2 87 8
HIPK3 103 4
IGF-1R 111 15
IKK beta 106 0
IKK epsilon
9
 0
IR 103 17
IRAK4 76 7
IRR 57 3
JAK2
7
 0
JNK1 100 3
JNK2 98 5
JNK3 93 3
Lck 104 4
LKB1 120 4
MAPKAP-K2 108 2
MAPKAP-K3 99 2
MARK1 13 2
MARK2
10
 1
MARK3
6
 1
MARK4 15 3
MEKK1 78 3
MELK 57 3
MINK1 105 6
MKK1 64 16
MLK1 17 2
MLK3 11 0
MNK1 60 0
MNK2 18 7
MSK1 84 5
MST2 106 6
MST4 145 12
NEK2a 100 11
NEK6 106 12
NUAK1
7
 4
p38 alpha MAPK 104 10
p38 beta MAPK 71 1
p38 delta MAPK 102 11
p38 gamma MAPK 97 7
PAK2 106 3
PAK4 97 8
PAK5 100 8
PAK6 114 4
PDK1
9
 2
PHK 71 2
PIM1 107 4
PIM2 98 9
PIM3 99 1
PKA 96 0
PKB alpha 117 11
PKB beta 104 1
PKC alpha 87 8
PKC zeta 96 0
PKD1 78 0
PLK1 95 2
PRAK 106 3
PRK2 58 3
RIPK2 105 3
ROCK 2 58 7
RSK1 83 5
RSK2 102 17
S6K1 89 1
SGK1 95 4
SmMLCK 93 4
Src 98 6
SRPK1 108 4
SYK 91 12
TAK1
8
 1
TBK1
9
 4
TrkA 52 2
TTK 89 5
VEGFR1 37 1
YES1 117 0
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
3
 0
Aurora A
2
 0
Aurora B
3
 1
BRSK1 34 0
BRSK2 31 4
BTK 61 10
CAMK1 79 2
CAMKK beta 13 0
CDK2-Cyclin A
5
 4
CHK1 19 1
CHK2 20 1
CK1 delta 93 3
CK2 87 1
CLK2 13 1
CSK 65 6
DAPK1 38 5
DYRK1A 58 1
DYRK2 28 1
DYRK3 24 2
EF2K 99 2
EPH-A2 70 2
EPH-A4 82 1
EPH-B2 100 2
EPH-B3 115 37
EPH-B4 94 16
ERK1 48 9
ERK2 46 1
ERK8 16 3
FGF-R1 12 0
GCK
10
 2
GSK3 beta 17 3
HER4 82 2
HIPK1 82 6
HIPK2 59 0
HIPK3 76 7
IGF-1R 85 13
IKK beta 82 4
IKK epsilon
5
 0
IR 77 1
IRAK4 22 1
IRR 28 1
JAK2
2
 1
JNK1 69 2
JNK2 57 4
JNK3 68 6
Lck 66 0
LKB1 63 8
MAPKAP-K2 88 8
MAPKAP-K3 93 5
MARK1
8
 1
MARK2
5
 1
MARK3
3
 1
MARK4
9
 0
MEKK1 32 2
MELK 11 1
MINK1 70 2
MKK1 21 1
MLK1
5
 1
MLK3
2
 0
MNK1 18 0
MNK2 15 8
MSK1 60 6
MST2 64 8
MST4 111 1
NEK2a 64 4
NEK6 80 10
NUAK1
7
 0
p38 alpha MAPK 108 4
p38 beta MAPK 89 1
p38 delta MAPK 58 5
p38 gamma MAPK 61 2
PAK2 94 2
PAK4 40 1
PAK5 66 3
PAK6 87 10
PDK1
3
 0
PHK 27 2
PIM1 92 4
PIM2 92 8
PIM3 74 2
PKA 64 4
PKB alpha 93 2
PKB beta 95 1
PKC alpha 50 12
PKC zeta 90 1
PKD1 22 1
PLK1 93 7
PRAK 91 14
PRK2 18 1
RIPK2 77 1
ROCK 2
10
 2
RSK1 28 1
RSK2 42 5
S6K1 37 2
SGK1 42 2
SmMLCK 92 1
Src 64 4
SRPK1 101 0
SYK 35 3
TAK1
1
 0
TBK1
6
 2
TrkA 28 2
TTK 53 14
VEGFR1
8
 1
YES1 66 4
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
1
 0
Aurora B
1
 0
Aurora C
2
 2
BRSK2
0
 0
CAMK1 12 2
CAMKK beta
10
 1
CDK2-Cyclin A
0
 0
CHK1
2
 0
CHK2
2
 0
CK1 delta 83 3
CK2 38 5
CSK 69 3
DYRK1A 35 16
DYRK2
7
 0
DYRK3
4
 7
EF2K 74 1
EPH-A2 66 6
ERK1
5
 0
ERK2
6
 0
ERK8
2
 1
FGF-R1
2
 0
GSK3 beta
3
 0
HIPK2 14 0
HIPK3 33 2
IKK beta 41 1
IKK epsilon
0
 0
IRR
10
 0
JNK1 16 1
JNK2 17 5
JNK3 38 0
Lck 14 0
MAPKAP-K2 70 8
MAPKAP-K3 80 1
MARK3
2
 2
MELK
4
 1
MKK1
2
 0
MNK1
1
 0
MNK2
6
 8
MSK1 25 4
MST2 15 2
MST4 13 1
NEK2a
7
 0
NEK6 63 8
NEK7 84 9
p38 alpha MAPK 87 10
p38 beta MAPK 60 3
p38 delta MAPK 27 1
p38 gamma MAPK 17 3
PAK4
6
 4
PAK5 15 4
PAK6 16 3
PDK1
1
 0
PHK
2
 1
PIM1 53 0
PIM2 75 9
PIM3 18 6
PKA
10
 0
PKB alpha 46 7
PKB beta 55 11
PKC alpha
10
 0
PKC zeta 66 7
PKD1
2
 0
PLK1 55 0
PRAK 43 0
PRK2
1
 7
ROCK 2
2
 0
RSK1
4
 1
RSK2 11 0
S6K1
6
 0
SGK1
8
 0
SmMLCK 84 10
Src
10
 0
SRPK1 79 15
SYK
6
 4
TBK1
2
 0
YES1 11 1