Inhibitor | BX-912  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-912   C20H23BrN8O 471.35 702674-56-4 11754511 PDK Feldman RI. (2005) J. Biol. Chem. 2005 May 20 280(20) 19867-74

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 87 7
AMPK (hum) 28 1
ASK1 96 2
Aurora A 62 9
Aurora B
7
 2
BRK 89 0
BRSK1 44 1
BRSK2 50 6
BTK 91 7
CAMK1 93 11
CAMKK beta 65 2
CDK2-Cyclin A 50 1
CDK9-Cyclin T1 86 6
CHK1 50 3
CHK2 67 5
CK1 delta 92 3
CK1 gamma 2 99 14
CK2 103 11
CLK2 82 1
CSK 93 9
DAPK1 100 2
DDR2 89 5
DYRK1A 84 8
DYRK2 101 5
DYRK3 99 5
EF2K 91 24
EIF2AK3 97 1
EPH-A2 100 5
EPH-A4 98 14
EPH-B1 109 1
EPH-B2 93 11
EPH-B3 104 5
EPH-B4 104 4
ERK1 88 3
ERK2 89 3
ERK5 83 2
ERK8 42 5
FGF-R1 49 6
GCK 39 7
GSK3 beta 87 15
HER4 94 9
HIPK1 87 14
HIPK2 92 1
HIPK3 94 4
IGF-1R 80 3
IKK beta 111 6
IKK epsilon 62 1
IR 82 25
IRAK1 100 1
IRAK4 42 1
IRR 102 12
JAK2 27 0
JNK1 102 13
JNK2 93 1
JNK3 101 4
Lck 95 16
LKB1 79 4
MAP4K3 75 6
MAP4K5 70 2
MAPKAP-K2 97 9
MAPKAP-K3 106 6
MARK1 41 4
MARK2 42 5
MARK3 18 1
MARK4 32 5
MEKK1 94 6
MELK 72 8
MINK1 73 7
MKK1 63 3
MKK2 57 5
MKK6 74 12
MLK1 16 0
MLK3 11 1
MNK1 97 17
MNK2 95 4
MPSK1 121 1
MSK1 100 8
MST2 56 0
MST3 79 5
MST4 77 4
NEK2a 101 13
NEK6 101 1
NUAK1
2
 0
OSR1 100 12
p38 alpha MAPK 96 17
p38 beta MAPK 92 3
p38 delta MAPK 99 33
p38 gamma MAPK 86 5
PAK2 99 7
PAK4 93 3
PAK5 89 9
PAK6 104 21
PDGFRA 65 1
PDK1 43 9
PHK 101 6
PIM1 105 1
PIM2 105 4
PIM3 113 3
PINK 84 2
PKA 69 6
PKB alpha 87 1
PKB beta 94 10
PKC alpha 82 6
PKC gamma 110 3
PKC zeta 109 21
PKD1 81 1
PLK1 106 10
PRAK 112 8
PRK2 68 3
RIPK2 68 4
ROCK 2 102 5
RSK1 82 16
RSK2 62 11
S6K1 80 2
SGK1 87 1
SIK2
9
 0
SIK3 42 2
SmMLCK 88 13
Src 89 3
SRPK1 96 3
STK33 76 4
SYK 74 16
TAK1 49 1
TAO1 81 2
TBK1 45 5
TESK1 102 13
TGFBR1 87 6
TIE2 85 2
TLK1 95 10
TrkA 40 4
TSSK1 69 11
TTBK1 94 3
TTBK2 109 25
TTK 95 10
ULK1 48 6
ULK2 91 9
VEGFR1
10
 0
WNK1 112 6
YES1 82 7
ZAP70 100 3
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 35 0
AMPK (hum)
5
 1
ASK1 46 1
Aurora A 14 3
Aurora B
2
 1
BRK 39 2
BRSK1 12 1
BRSK2 13 0
BTK 40 7
CAMK1 89 9
CAMKK beta 18 0
CDK2-Cyclin A 12 4
CDK9-Cyclin T1 60 7
CHK1 14 0
CHK2 18 2
CK1 delta 87 3
CK1 gamma 2 84 4
CK2 80 4
CLK2 26 0
CSK 88 9
DAPK1 76 9
DDR2 69 4
DYRK1A 75 8
DYRK2 79 1
DYRK3 83 3
EF2K 101 30
EIF2AK3 94 5
EPH-A2 87 9
EPH-A4 86 3
EPH-B1 110 5
EPH-B2 79 4
EPH-B3 99 6
EPH-B4 104 10
ERK1 67 5
ERK2 63 1
ERK5 63 8
ERK8
8
 2
FGF-R1
9
 2
GCK 11 3
GSK3 beta 81 0
HER4 69 21
HIPK1 63 7
HIPK2 90 9
HIPK3 81 1
IGF-1R 45 4
IKK beta 94 3
IKK epsilon 24 1
IR 34 7
IRAK1 48 5
IRAK4
10
 1
IRR 73 6
JAK2
10
 2
JNK1 74 7
JNK2 59 1
JNK3 76 0
Lck 43 3
LKB1 49 6
MAP4K3 18 2
MAP4K5 35 2
MAPKAP-K2 103 13
MAPKAP-K3 98 4
MARK1
10
 0
MARK2 12 2
MARK3
4
 1
MARK4
7
 1
MEKK1 97 1
MELK 30 3
MINK1 52 10
MKK1 20 3
MKK2 20 3
MKK6 56 7
MLK1
2
 0
MLK3 11 5
MNK1 79 2
MNK2 45 2
MPSK1 105 2
MSK1 74 11
MST2 31 2
MST3 49 3
MST4 48 3
NEK2a 82 13
NEK6 95 17
NUAK1
1
 0
OSR1 89 4
p38 alpha MAPK 91 3
p38 beta MAPK 85 3
p38 delta MAPK 72 4
p38 gamma MAPK 84 3
PAK2 87 20
PAK4 54 4
PAK5 73 4
PAK6 87 10
PDGFRA 29 5
PDK1
8
 0
PHK 48 0
PIM1 105 5
PIM2 105 15
PIM3 104 3
PINK 88 4
PKA 30 1
PKB alpha 81 3
PKB beta 91 11
PKC alpha 73 20
PKC gamma 86 12
PKC zeta 118 6
PKD1 37 1
PLK1 77 17
PRAK 101 8
PRK2 32 4
RIPK2 47 2
ROCK 2 75 2
RSK1 42 0
RSK2 45 4
S6K1 52 4
SGK1 60 2
SIK2
2
 1
SIK3 11 1
SmMLCK 80 5
Src 53 5
SRPK1 96 13
STK33 33 6
SYK 21 4
TAK1 15 2
TAO1 46 8
TBK1 12 3
TESK1 93 5
TGFBR1 92 6
TIE2 58 13
TLK1 91 0
TrkA 17 5
TSSK1 45 5
TTBK1 101 5
TTBK2 89 6
TTK 76 5
ULK1 15 1
ULK2 42 4
VEGFR1
2
 0
WNK1 104 4
YES1 42 8
ZAP70 88 2