Inhibitor | BML-258 (SK1-I)  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	110	3
AMPK	104	9
ASK1	115	8
Aurora A	116	3
Aurora B	100	2
BRK	104	4
BRSK1	114	4
BRSK2	130	7
BTK	107	25
CAMK1	106	13
CAMKK beta	97	4
CDK2-Cyclin A	98	4
CHK1	96	1
CHK2	92	3
CK1 delta	88	9
CK2	78	12
CLK2	106	4
CSK	104	1
DAPK1	109	7
DYRK1A	83	4
DYRK2	116	3
DYRK3	93	6
EF2K	93	13
EPH-A2	103	8
EPH-A4	100	4
EPH-B1	126	14
EPH-B2	115	5
EPH-B3	104	0
EPH-B4	122	7
ERK1	108	23
ERK2	98	2
ERK8	82	1
FGF-R1	115	6
GCK	86	2
GSK3 beta	83	8
HER4	127	6
HIPK1	92	6
HIPK2	108	8
HIPK3	118	13
IGF-1R	87	12
IKK beta	91	1
IKK epsilon	106	3
IR	107	7
IRAK4	72	6
IRR	99	6
JAK2	118	14
JNK1	98	6
JNK2	85	6
JNK3	93	6
Lck	106	11
LKB1	93	5
MAPKAP-K2	98	12
MAPKAP-K3	115	13
MARK1	114	12
MARK2	89	5
MARK3	101	7
MARK4	90	11
MEKK1	93	8
MELK	108	2
MINK1	107	14
MKK1	97	16
MKK2	104	10
MKK6	102	5
MLK1	105	6
MLK3	102	8
MNK1	101	3
MNK2	111	3
MPSK1	104	2
MSK1	110	6
MST2	96	2
MST4	116	7
NEK2a	110	3
NEK6	92	4
NUAK1	105	2
p38 alpha MAPK	95	8
p38 beta MAPK	99	9
p38 delta MAPK	90	9
p38 gamma MAPK	93	4
PAK2	113	2
PAK4	91	4
PAK5	104	3
PAK6	105	11
PDK1	107	4
PHK	99	5
PIM1	100	0
PIM2	103	6
PIM3	118	4
PKA	110	2
PKB alpha	99	5
PKB beta	85	2
PKC alpha	96	0
PKC gamma	101	6
PKC zeta	106	2
PKD1	107	4
PLK1	106	1
PRAK	89	2
PRK2	78	4
RIPK2	119	8
ROCK 2	110	1
RSK1	95	1
RSK2	87	3
S6K1	114	8
SGK1	83	5
SmMLCK	90	2
Src	105	11
SRPK1	92	4
STK33	100	0
SYK	134	4
TAK1	100	7
TAO1	102	11
TBK1	111	13
TIE2	141	5
TrkA	103	1
TTK	95	4
VEGFR1	95	2
YES1	123	1
ZAP70	116	2

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	106	11
AMPK	96	0
ASK1	99	3
Aurora A	105	4
Aurora B	102	4
BRK	93	8
BRSK1	111	0
BRSK2	108	1
BTK	103	5
CAMK1	101	11
CAMKK beta	81	15
CDK2-Cyclin A	79	7
CHK1	92	7
CHK2	84	4
CK1 delta	87	7
CK2	87	12
CLK2	104	12
CSK	101	15
DAPK1	101	11
DYRK1A	91	6
DYRK2	124	3
DYRK3	98	1
EF2K	76	0
EPH-A2	91	9
EPH-A4	101	8
EPH-B1	108	7
EPH-B2	105	10
EPH-B3	100	9
EPH-B4	101	8
ERK1	97	9
ERK2	90	9
ERK8	86	1
FGF-R1	111	12
GCK	72	2
GSK3 beta	88	3
HER4	107	20
HIPK1	112	6
HIPK2	106	6
HIPK3	112	2
IGF-1R	86	2
IKK beta	97	7
IKK epsilon	95	6
IR	103	20
IRAK4	66	0
IRR	94	3
JAK2	98	3
JNK1	94	3
JNK2	90	2
JNK3	103	7
Lck	92	8
LKB1	89	0
MAPKAP-K2	95	6
MAPKAP-K3	119	1
MARK1	112	17
MARK2	97	9
MARK3	107	7
MARK4	89	8
MEKK1	99	4
MELK	99	7
MINK1	93	11
MKK1	102	5
MKK2	103	12
MKK6	98	4
MLK1	108	6
MLK3	106	4
MNK1	92	16
MNK2	98	3
MPSK1	98	8
MSK1	104	18
MST2	90	0
MST4	96	9
NEK2a	103	2
NEK6	86	12
NUAK1	108	6
p38 alpha MAPK	87	13
p38 beta MAPK	106	2
p38 delta MAPK	99	5
p38 gamma MAPK	80	11
PAK2	103	1
PAK4	91	9
PAK5	100	8
PAK6	108	7
PDK1	106	2
PHK	86	0
PIM1	95	11
PIM2	109	3
PIM3	121	6
PKA	106	2
PKB alpha	97	8
PKB beta	90	13
PKC alpha	88	5
PKC gamma	109	8
PKC zeta	108	3
PKD1	112	4
PLK1	94	7
PRAK	99	12
PRK2	70	1
RIPK2	95	3
ROCK 2	94	5
RSK1	98	4
RSK2	95	1
S6K1	108	6
SGK1	87	3
SmMLCK	95	12
Src	100	3
SRPK1	89	3
STK33	100	11
SYK	105	6
TAK1	108	4
TAO1	108	9
TBK1	82	39
TIE2	118	3
TrkA	110	9
TTK	91	4
VEGFR1	81	5
YES1	100	9
ZAP70	106	10

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	109	10
AMPK	94	6
ASK1	94	0
Aurora A	92	15
Aurora B	93	0
BRK	104	2
BRSK1	97	1
BRSK2	108	7
BTK	103	15
CAMK1	89	5
CAMKK beta	90	2
CDK2-Cyclin A	88	3
CHK1	86	9
CHK2	82	8
CK1 delta	81	4
CK2	83	2
CLK2	97	11
CSK	98	5
DAPK1	103	18
DYRK1A	84	6
DYRK2	119	7
DYRK3	93	9
EF2K	69	1
EPH-A2	91	6
EPH-A4	96	7
EPH-B1	115	18
EPH-B2	108	5
EPH-B3	86	0
EPH-B4	123	13
ERK1	85	4
ERK2	100	5
ERK8	77	0
FGF-R1	104	1
GCK	71	9
GSK3 beta	71	2
HER4	105	6
HIPK1	94	18
HIPK2	106	5
HIPK3	102	3
IGF-1R	93	14
IKK beta	100	6
IKK epsilon	86	4
IR	99	2
IRAK4	67	1
IRR	100	5
JAK2	100	10
JNK1	90	21
JNK2	88	5
JNK3	98	8
Lck	84	11
LKB1	98	4
MAPKAP-K2	91	4
MAPKAP-K3	123	7
MARK1	104	6
MARK2	83	6
MARK3	105	0
MARK4	93	10
MEKK1	89	0
MELK	98	14
MINK1	111	13
MKK1	97	9
MKK2	109	19
MKK6	99	1
MLK1	100	3
MLK3	109	12
MNK1	93	1
MNK2	102	14
MPSK1	100	4
MSK1	95	1
MST2	94	7
MST4	108	13
NEK2a	108	7
NEK6	84	9
NUAK1	101	5
p38 alpha MAPK	80	9
p38 beta MAPK	95	2
p38 delta MAPK	90	1
p38 gamma MAPK	87	5
PAK2	113	8
PAK4	85	5
PAK5	101	4
PAK6	103	5
PDK1	122	9
PHK	76	0
PIM1	95	10
PIM2	97	2
PIM3	107	2
PKA	107	12
PKB alpha	107	24
PKB beta	86	2
PKC alpha	89	5
PKC gamma	96	1
PKC zeta	92	5
PKD1	115	15
PLK1	96	3
PRAK	90	3
PRK2	58	1
RIPK2	100	4
ROCK 2	116	3
RSK1	81	8
RSK2	81	11
S6K1	100	0
SGK1	78	4
SmMLCK	91	15
Src	111	13
SRPK1	83	9
STK33	89	16
SYK	92	13
TAK1	111	2
TAO1	91	6
TBK1	93	1
TIE2	113	4
TrkA	86	0
TTK	86	4
VEGFR1	83	4
YES1	109	2
ZAP70	92	0