Inhibitor | BX-517 Analog (compound 7b)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
BX-517 Analog (compound 7b)   C19H15N5O2 345.35 11588244 PDK1 Islam I. (2007) Bioorganic and Medicinal Chemistry Letters 17 3819-3825

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK
5
 0
BRSK2 13 3
BTK 86 11
CAMK1 112 12
CAMKK beta 67 7
CDK2-Cyclin A 63 0
CHK1 85 2
CHK2
-1
 0
CK1 delta 90 0
CK2 93 17
CSK 98 0
DYRK1A 42 9
DYRK2 19 3
DYRK3 19 3
EF2K 102 14
EPH-A2 93 0
EPH-B3 107 1
ERK1 71 7
ERK2 81 10
ERK8
5
 0
FGF-R1 17 3
GSK3 beta 11 1
HIPK2 33 1
IGF-1R 49 49
IKK beta 75 1
IKK epsilon 51 14
IR 112 14
IRR 35 0
JNK1 124 1
JNK2 214 172
Lck 44 4
MAPKAP-K2 86 3
MARK3 16 3
MELK 16 0
MKK1
8
 1
MNK1 80 0
MNK2 75 12
MSK1 98 1
MST2
8
 0
MST4 55 32
NEK2a 100 10
NEK6 92 6
p38 alpha MAPK 81 8
p38 beta MAPK 103 0
p38 delta MAPK 85 9
p38 gamma MAPK 93 6
PAK4 64 5
PAK5 75 10
PAK6 86 1
PDK1 20 1
PHK 13 0
PIM1 43 2
PIM2 76 6
PIM3 30 0
PKA 78 0
PKB alpha 85 4
PKB beta 88 3
PKC alpha 106 3
PKC zeta 85 4
PKD1 30 2
PLK1 86 5
PRAK 95 6
PRK2 25 11
ROCK 2 103 25
RSK1 24 4
RSK2 38 4
S6K1 76 0
SGK1 77 5
SmMLCK 54 7
Src 41 2
SRPK1 90 4
SYK 95 23
TBK1 27 17
VEGFR1
7
 0
YES1 32 4
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
6
 4
BRSK2
10
 3
BTK 29 5
CAMK1 69 5
CAMKK beta 41 12
CDK2-Cyclin A 14 2
CHK1
4
 0
CHK2
-5
 0
CK1 delta 59 10
CK2 65 5
CSK 69 6
DYRK1A 11 6
DYRK2
2
 0
DYRK3
4
 1
EF2K 86 3
EPH-A2 54 5
EPH-B3 90 11
ERK1 60 52
ERK2 41 9
ERK8
2
 0
FGF-R1
2
 0
GSK3 beta
7
 3
HIPK2
7
 0
IGF-1R 33 7
IKK beta 75 27
IKK epsilon 12 1
IR 101 11
IRR 16 5
JNK1 99 1
JNK2 43 0
Lck
10
 0
MAPKAP-K2 49 6
MARK3
5
 1
MELK
3
 0
MKK1
1
 0
MNK1 54 0
MNK2 46 5
MSK1 73 2
MST2
2
 1
MST4 18 0
NEK2a 75 2
NEK6 76 10
p38 alpha MAPK 80 4
p38 beta MAPK 80 5
p38 delta MAPK 62 1
p38 gamma MAPK 86 4
PAK4 31 0
PAK5 43 0
PAK6 77 3
PDK1
3
 0
PHK
1
 0
PIM1
9
 0
PIM2 34 0
PIM3
9
 2
PKA 66 0
PKB alpha 69 0
PKB beta 77 7
PKC alpha 83 5
PKC zeta 66 1
PKD1
3
 0
PLK1 42 4
PRAK 50 6
PRK2
5
 3
ROCK 2 37 4
RSK1
10
 4
RSK2 32 14
S6K1 32 0
SGK1 32 0
SmMLCK 11 1
Src
7
 0
SRPK1 75 1
SYK 40 1
TBK1
7
 6
VEGFR1
3
 1
YES1
8
 0
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
4
 1
BRSK2 18 3
BTK
9
 6
CAMK1 19 0
CAMKK beta 35 3
CDK2-Cyclin A
6
 0
CHK1
1
 0
CHK2
1
 4
CK1 delta 20 5
CK2 21 1
CSK 42 6
DYRK1A 27 33
DYRK2
0
 0
DYRK3
1
 0
EF2K 116 7
EPH-A2 20 1
EPH-B3 53 8
ERK1
4
 0
ERK2 16 3
ERK8
1
 0
FGF-R1
1
 0
GSK3 beta
3
 2
HIPK2
1
 0
IGF-1R
1
 0
IKK beta 26 4
IKK epsilon 11 6
IR 26 6
IRR
5
 2
JNK1 48 4
JNK2 17 0
Lck
3
 0
MAPKAP-K2
10
 6
MARK3
3
 1
MELK
0
 0
MKK1
2
 1
MNK1 30 14
MNK2 16 2
MSK1 30 0
MST2
0
 0
MST4 21 6
NEK2a 28 1
NEK6 38 2
p38 alpha MAPK 45 6
p38 beta MAPK 49 9
p38 delta MAPK 22 1
p38 gamma MAPK 75 27
PAK4 29 31
PAK5
8
 0
PAK6 38 4
PDK1
0
 2
PHK
0
 0
PIM1
2
 2
PIM2
8
 0
PIM3
7
 2
PKA 32 5
PKB alpha 62 7
PKB beta 36 4
PKC alpha 27 7
PKC zeta 21 4
PKD1
3
 2
PLK1 18 6
PRAK
8
 1
PRK2
6
 0
ROCK 2
7
 1
RSK1
5
 0
RSK2 22 3
S6K1 12 1
SGK1
6
 2
SmMLCK
1
 1
Src
1
 0
SRPK1 36 3
SYK
7
 0
TBK1 11 9
VEGFR1
1
 0
YES1
3
 1