Inhibitor | PP242  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
PP242   C16H16N6O 308.30 1092351-67-1 24905147 mTOR Feldman ME (2009) PLoS Biol 7(2)

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 74 0
ASK1 106 15
Aurora A 79 12
Aurora B 80 1
BRSK1 46 6
BRSK2 41 4
BTK 68 6
CAMK1 91 8
CAMKK beta 39 7
CDK2-Cyclin A 103 4
CHK1 85 5
CHK2 60 3
CK1 delta 51 2
CK2 81 13
CLK2 35 13
CSK 93 3
DAPK1 28 6
DYRK1A 94 1
DYRK2 35 3
DYRK3 22 1
EF2K 104 1
EPH-A2 48 7
EPH-A4 95 2
EPH-B1 93 1
EPH-B2 90 14
EPH-B3 72 8
EPH-B4 84 4
ERK1 97 2
ERK2 103 6
ERK8 78 6
FGF-R1 30 7
GCK 12 0
GSK3 beta 73 6
HER4 85 2
HIPK1 61 4
HIPK2 26 2
HIPK3 61 11
IGF-1R 83 15
IKK beta 87 2
IKK epsilon 86 1
IR 104 5
IRAK4 65 0
IRR 56 10
JAK2 13 1
JNK1 95 5
JNK2 91 4
JNK3 109 2
Lck 36 2
LKB1 39 7
MAPKAP-K2 94 5
MAPKAP-K3 98 7
MARK1 96 11
MARK2 75 5
MARK3 87 3
MARK4 111 10
MEKK1 29 2
MELK 59 3
MINK1 44 2
MKK1 74 7
MKK2 96 2
MKK6 97 10
MLK1 48 0
MLK3 70 4
MNK1 71 11
MNK2 80 3
MSK1 85 1
MST2 66 6
MST4 63 8
NEK2a 88 12
NEK6 90 3
NUAK1 70 2
p38 alpha MAPK 100 5
p38 beta MAPK 90 8
p38 delta MAPK 87 5
p38 gamma MAPK 74 2
PAK2 102 11
PAK4 63 2
PAK5 84 4
PAK6 92 15
PDK1 80 2
PHK 95 1
PIM1 53 4
PIM2 69 7
PIM3 55 0
PKA 91 0
PKB alpha 81 6
PKB beta 88 0
PKC alpha 50 9
PKC zeta 87 8
PKD1 89 6
PLK1 102 1
PRAK 108 7
PRK2 68 12
RIPK2 46 12
ROCK 2 91 2
RSK1 81 3
RSK2 68 11
S6K1 60 5
SGK1 96 0
SmMLCK 71 2
Src 32 2
SRPK1 92 3
SYK 88 10
TAK1 89 3
TAO1 89 8
TBK1 91 6
TrkA 33 1
TTK 72 2
VEGFR1 51 5
YES1 54 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 25 0
ASK1 82 1
Aurora A 18 6
Aurora B 33 2
BRSK1 31 6
BRSK2 43 5
BTK 35 6
CAMK1 28 1
CAMKK beta 20 2
CDK2-Cyclin A 100 5
CHK1 67 3
CHK2 21 2
CK1 delta 17 8
CK2 42 12
CLK2
8
 2
CSK 85 1
DAPK1
7
 2
DYRK1A 68 4
DYRK2
8
 1
DYRK3
5
 1
EF2K 88 8
EPH-A2 45 9
EPH-A4 35 1
EPH-B1 48 3
EPH-B2 28 1
EPH-B3 18 3
EPH-B4 26 1
ERK1 87 4
ERK2 74 3
ERK8 39 4
FGF-R1
10
 0
GCK
5
 1
GSK3 beta 33 1
HER4 40 9
HIPK1 16 4
HIPK2 14 5
HIPK3 38 9
IGF-1R 63 10
IKK beta 79 9
IKK epsilon 58 3
IR 108 13
IRAK4 25 6
IRR 28 1
JAK2
7
 1
JNK1 85 12
JNK2 88 3
JNK3 89 6
Lck 42 13
LKB1 17 1
MAPKAP-K2 90 8
MAPKAP-K3 83 2
MARK1 49 2
MARK2 71 6
MARK3 52 3
MARK4 100 11
MEKK1 20 0
MELK 58 11
MINK1
6
 1
MKK1 35 2
MKK2 67 14
MKK6 80 5
MLK1
6
 0
MLK3 16 0
MNK1 39 12
MNK2 44 0
MSK1 58 6
MST2 27 0
MST4 25 2
NEK2a 71 13
NEK6 89 8
NUAK1 38 0
p38 alpha MAPK 84 3
p38 beta MAPK 60 6
p38 delta MAPK 97 0
p38 gamma MAPK 41 8
PAK2 87 3
PAK4 38 0
PAK5 36 2
PAK6 50 3
PDK1 49 6
PHK 73 5
PIM1 18 5
PIM2 27 1
PIM3 24 0
PKA 58 5
PKB alpha 60 0
PKB beta 79 1
PKC alpha 16 0
PKC zeta 48 1
PKD1 75 12
PLK1 74 1
PRAK 98 8
PRK2 39 9
RIPK2
10
 0
ROCK 2 66 3
RSK1 32 0
RSK2 41 0
S6K1 30 3
SGK1 86 1
SmMLCK 34 0
Src 15 1
SRPK1 70 10
SYK 68 8
TAK1 48 4
TAO1 44 0
TBK1 90 6
TrkA 27 4
TTK 46 3
VEGFR1 19 2
YES1 19 3
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 28 7
Aurora B 27 5
BRSK2
4
 2
BTK
5
 2
CAMK1 33 4
CAMKK beta 30 0
CDK2-Cyclin A 40 3
CHK1 34 6
CHK2
2
 0
CK1 delta
9
 1
CK2 40 3
CSK 34 0
DYRK1A 55 5
DYRK2
7
 2
DYRK3
2
 1
EF2K 106 2
EPH-A2
3
 0
EPH-B3
5
 4
ERK1 81 4
ERK2 88 4
ERK8
6
 0
FGF-R1
2
 0
GSK3 beta 60 10
HIPK2
7
 1
IGF-1R 89 8
IKK beta 84 4
IKK epsilon 64 7
IR 58 6
IRR 29 4
JNK1 103 1
JNK2 101 30
Lck
4
 0
MAPKAP-K2 94 3
MARK3 31 0
MELK 13 2
MKK1
10
 1
MNK1 12 0
MNK2 42 2
MSK1 49 1
MST2
10
 0
MST4 13 1
NEK2a 54 1
NEK6 96 2
p38 alpha MAPK 90 8
p38 beta MAPK 77 5
p38 delta MAPK 73 5
p38 gamma MAPK 72 12
PAK4 28 3
PAK5 34 1
PAK6 38 2
PDK1 60 1
PHK 25 1
PIM1 21 1
PIM2 36 3
PIM3 13 0
PKA 45 2
PKB alpha 39 4
PKB beta 89 7
PKC alpha
9
 2
PKC zeta 51 8
PKD1 71 9
PLK1 47 18
PRAK 92 2
PRK2 22 3
ROCK 2 77 2
RSK1 19 1
RSK2 16 0
S6K1 50 3
SGK1 69 2
SmMLCK
6
 1
Src
2
 1
SRPK1 63 7
SYK 61 8
TBK1 95 0
VEGFR1
2
 1
YES1
-8
 15