| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| PKR Inhibitor | C13H8N4OS | 268.30 | 608512-97-6 | 6490494 | PKR | Ingrand S (2007) FEBS Lett. 581(23):4473-8 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL | 71 | 3 |
| AMPK |
5
|
2 |
| AMPK (hum) |
3
|
0 |
| ASK1 | 15 | 0 |
| Aurora A | 12 | 0 |
| Aurora B |
4
|
1 |
| BRK | 68 | 9 |
| BRSK1 |
3
|
0 |
| BRSK2 |
6
|
2 |
| BTK | 57 | 7 |
| CAMK1 | 66 | 4 |
| CAMKK beta | 33 | 8 |
| CDK2-Cyclin A |
5
|
1 |
| CDK9-Cyclin T1 | 11 | 0 |
| CHK1 | 16 | 2 |
| CHK2 | 38 | 2 |
| CK1 delta | 19 | 5 |
| CK1 gamma 2 | 55 | 9 |
| CK2 | 23 | 5 |
| CLK2 |
2
|
1 |
| CSK | 98 | 7 |
| DAPK1 | 39 | 3 |
| DDR2 | 62 | 6 |
| DYRK1A |
3
|
1 |
| DYRK2 |
4
|
1 |
| DYRK3 |
7
|
1 |
| EF2K | 87 | 13 |
| EIF2AK3 | 62 | 3 |
| EPH-A2 | 46 | 4 |
| EPH-A4 | 63 | 4 |
| EPH-B1 | 66 | 10 |
| EPH-B2 | 64 | 3 |
| EPH-B3 | 75 | 28 |
| EPH-B4 | 62 | 2 |
| ERK1 |
1
|
0 |
| ERK2 |
8
|
4 |
| ERK5 |
9
|
3 |
| ERK8 |
3
|
1 |
| FGF-R1 | 27 | 1 |
| GCK |
4
|
1 |
| GSK3 beta |
2
|
0 |
| HER4 | 75 | 15 |
| HIPK1 | 47 | 2 |
| HIPK2 | 14 | 1 |
| HIPK3 | 37 | 2 |
| IGF-1R | 54 | 6 |
| IKK beta | 35 | 4 |
| IKK epsilon |
8
|
4 |
| IR | 57 | 3 |
| IRAK1 |
6
|
1 |
| IRAK4 | 26 | 2 |
| IRR | 23 | 1 |
| JAK2 | 12 | 1 |
| JNK1 | 34 | 1 |
| JNK2 | 41 | 4 |
| JNK3 | 48 | 13 |
| Lck | 58 | 4 |
| LKB1 | 67 | 3 |
| MAP4K3 |
-1
|
2 |
| MAP4K5 |
4
|
5 |
| MAPKAP-K2 | 72 | 3 |
| MAPKAP-K3 | 95 | 2 |
| MARK1 |
9
|
1 |
| MARK2 | 11 | 3 |
| MARK3 |
7
|
1 |
| MARK4 | 11 | 0 |
| MEKK1 | 81 | 1 |
| MELK |
6
|
1 |
| MINK1 |
4
|
0 |
| MKK1 |
2
|
0 |
| MKK2 |
2
|
0 |
| MKK6 | 20 | 6 |
| MLK1 | 11 | 3 |
| MLK3 |
6
|
0 |
| MNK1 |
4
|
1 |
| MNK2 | 13 | 2 |
| MPSK1 | 86 | 2 |
| MSK1 | 13 | 2 |
| MST2 |
4
|
1 |
| MST3 | 12 | 1 |
| MST4 | 47 | 9 |
| NEK2a | 70 | 0 |
| NEK6 | 67 | 8 |
| NUAK1 |
2
|
1 |
| OSR1 | 58 | 0 |
| p38 alpha MAPK | 82 | 4 |
| p38 beta MAPK | 65 | 2 |
| p38 delta MAPK | 57 | 9 |
| p38 gamma MAPK | 26 | 2 |
| PAK2 | 86 | 3 |
| PAK4 | 45 | 3 |
| PAK5 | 62 | 4 |
| PAK6 | 80 | 10 |
| PDGFRA | 25 | 2 |
| PDK1 | 25 | 0 |
| PHK | 21 | 1 |
| PIM1 | 11 | 2 |
| PIM2 | 17 | 2 |
| PIM3 | 58 | 12 |
| PINK | 111 | 16 |
| PKA | 39 | 2 |
| PKB alpha | 85 | 2 |
| PKB beta | 69 | 10 |
| PKC alpha | 54 | 4 |
| PKC gamma | 82 | 8 |
| PKC zeta | 48 | 5 |
| PKD1 |
6
|
1 |
| PLK1 | 66 | 10 |
| PRAK | 67 | 3 |
| PRK2 |
2
|
0 |
| RIPK2 | 46 | 1 |
| ROCK 2 |
5
|
1 |
| RSK1 | 13 | 2 |
| RSK2 | 18 | 0 |
| S6K1 | 36 | 8 |
| SGK1 | 12 | 1 |
| SIK2 | 20 | 6 |
| SIK3 | 23 | 3 |
| SmMLCK | 19 | 2 |
| Src | 46 | 9 |
| SRPK1 | 88 | 15 |
| STK33 | 30 | 1 |
| SYK | 71 | 4 |
| TAK1 |
4
|
0 |
| TAO1 | 15 | 3 |
| TBK1 |
7
|
0 |
| TESK1 | 75 | 2 |
| TGFBR1 | 93 | 7 |
| TIE2 | 66 | 8 |
| TLK1 | 52 | 8 |
| TrkA |
6
|
1 |
| TSSK1 | 46 | 6 |
| TTBK1 | 77 | 12 |
| TTBK2 | 82 | 6 |
| TTK | 29 | 1 |
| ULK1 | 12 | 2 |
| ULK2 | 13 | 1 |
| VEGFR1 |
3
|
1 |
| WNK1 | 89 | 17 |
| YES1 | 69 | 7 |
| ZAP70 | 97 | 2 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL | 25 | 3 |
| AMPK |
1
|
0 |
| AMPK (hum) |
1
|
0 |
| ASK1 |
3
|
2 |
| Aurora A |
3
|
0 |
| Aurora B |
1
|
1 |
| BRK | 25 | 2 |
| BRSK1 |
1
|
0 |
| BRSK2 |
2
|
1 |
| BTK | 11 | 13 |
| CAMK1 | 24 | 2 |
| CAMKK beta |
10
|
0 |
| CDK2-Cyclin A |
5
|
2 |
| CDK9-Cyclin T1 |
2
|
2 |
| CHK1 |
4
|
0 |
| CHK2 |
10
|
1 |
| CK1 delta |
4
|
0 |
| CK1 gamma 2 | 24 | 4 |
| CK2 |
5
|
0 |
| CLK2 |
0
|
0 |
| CSK | 61 | 6 |
| DAPK1 |
10
|
0 |
| DDR2 | 23 | 1 |
| DYRK1A |
1
|
0 |
| DYRK2 |
1
|
0 |
| DYRK3 |
2
|
1 |
| EF2K | 52 | 7 |
| EIF2AK3 | 25 | 3 |
| EPH-A2 | 17 | 2 |
| EPH-A4 | 32 | 2 |
| EPH-B1 | 25 | 2 |
| EPH-B2 | 22 | 1 |
| EPH-B3 | 20 | 7 |
| EPH-B4 | 27 | 2 |
| ERK1 |
1
|
2 |
| ERK2 |
3
|
2 |
| ERK5 |
4
|
0 |
| ERK8 |
3
|
1 |
| FGF-R1 |
8
|
5 |
| GCK |
1
|
1 |
| GSK3 beta |
4
|
3 |
| HER4 | 41 | 12 |
| HIPK1 |
10
|
1 |
| HIPK2 |
3
|
0 |
| HIPK3 | 11 | 2 |
| IGF-1R |
4
|
1 |
| IKK beta | 14 | 1 |
| IKK epsilon |
1
|
0 |
| IR |
8
|
1 |
| IRAK1 |
6
|
1 |
| IRAK4 |
8
|
0 |
| IRR |
9
|
0 |
| JAK2 |
4
|
2 |
| JNK1 |
9
|
0 |
| JNK2 | 12 | 1 |
| JNK3 | 12 | 1 |
| Lck | 15 | 0 |
| LKB1 | 43 | 0 |
| MAP4K3 |
-1
|
3 |
| MAP4K5 |
-1
|
4 |
| MAPKAP-K2 | 42 | 6 |
| MAPKAP-K3 | 85 | 12 |
| MARK1 |
1
|
0 |
| MARK2 |
2
|
0 |
| MARK3 |
4
|
3 |
| MARK4 |
3
|
1 |
| MEKK1 | 63 | 1 |
| MELK |
3
|
0 |
| MINK1 |
1
|
0 |
| MKK1 |
0
|
0 |
| MKK2 |
1
|
0 |
| MKK6 | 12 | 3 |
| MLK1 |
2
|
0 |
| MLK3 |
2
|
1 |
| MNK1 |
2
|
1 |
| MNK2 |
2
|
1 |
| MPSK1 | 65 | 17 |
| MSK1 |
4
|
2 |
| MST2 |
3
|
1 |
| MST3 | 20 | 24 |
| MST4 |
2
|
1 |
| NEK2a | 16 | 1 |
| NEK6 | 56 | 13 |
| NUAK1 |
1
|
0 |
| OSR1 | 17 | 5 |
| p38 alpha MAPK | 65 | 9 |
| p38 beta MAPK | 24 | 2 |
| p38 delta MAPK | 17 | 1 |
| p38 gamma MAPK | 11 | 1 |
| PAK2 | 60 | 9 |
| PAK4 | 15 | 4 |
| PAK5 | 28 | 8 |
| PAK6 | 33 | 3 |
| PDGFRA | 12 | 3 |
| PDK1 |
8
|
0 |
| PHK |
4
|
0 |
| PIM1 |
5
|
4 |
| PIM2 |
4
|
0 |
| PIM3 |
2
|
1 |
| PINK | 96 | 14 |
| PKA |
10
|
0 |
| PKB alpha | 32 | 1 |
| PKB beta | 58 | 22 |
| PKC alpha | 25 | 3 |
| PKC gamma | 38 | 3 |
| PKC zeta | 21 | 1 |
| PKD1 |
3
|
1 |
| PLK1 | 27 | 0 |
| PRAK | 26 | 5 |
| PRK2 |
2
|
0 |
| RIPK2 | 15 | 1 |
| ROCK 2 |
2
|
1 |
| RSK1 |
4
|
0 |
| RSK2 |
6
|
0 |
| S6K1 | 12 | 1 |
| SGK1 |
10
|
9 |
| SIK2 |
4
|
0 |
| SIK3 |
4
|
1 |
| SmMLCK |
5
|
1 |
| Src | 12 | 0 |
| SRPK1 | 81 | 6 |
| STK33 |
10
|
1 |
| SYK | 30 | 3 |
| TAK1 |
1
|
0 |
| TAO1 |
4
|
1 |
| TBK1 |
5
|
2 |
| TESK1 | 42 | 5 |
| TGFBR1 | 63 | 5 |
| TIE2 | 25 | 2 |
| TLK1 | 20 | 2 |
| TrkA |
2
|
1 |
| TSSK1 | 15 | 1 |
| TTBK1 | 66 | 6 |
| TTBK2 | 75 | 14 |
| TTK | 15 | 1 |
| ULK1 |
4
|
0 |
| ULK2 |
3
|
0 |
| VEGFR1 |
2
|
0 |
| WNK1 | 91 | 3 |
| YES1 | 34 | 4 |
| ZAP70 | 98 | 10 |