Inhibitor | Princeton's TrkA inhibitor compound 20h  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Princeton's TrkA inhibitor compound 20h   C24H24BrF3N6O4S2 661.52 Trk A Kim S.H. Tokarski J.S. (2008) Bioorg. Med. Chem. Lett. 18 634-639

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 63 5
ASK1 106 1
Aurora A
3
 0
Aurora B 65 0
BRSK1 82 13
BRSK2 88 5
BTK 96 1
CAMK1 62 9
CAMKK beta 22 0
CDK2-Cyclin A 35 2
CHK1 54 1
CHK2 20 1
CK1 delta 99 6
CK2 119 11
CLK2
3
 0
CSK 103 12
DAPK1 99 5
DYRK1A 103 8
DYRK2 101 9
DYRK3 89 11
EF2K 113 8
EPH-A2 46 13
EPH-A4 22 6
EPH-B1 53 0
EPH-B2 11 1
EPH-B3 22 3
EPH-B4 15 1
ERK1 103 9
ERK2 99 6
ERK8
1
 0
FGF-R1 47 4
GCK 101 4
GSK3 beta 46 1
HER4 69 8
HIPK1 45 2
HIPK2 14 2
HIPK3 30 2
IGF-1R
2
 0
IKK beta 107 3
IKK epsilon 91 3
IR 19 3
IRAK4
5
 2
IRR 69 9
JAK2 84 9
JNK1 98 8
JNK2 98 1
JNK3 94 4
Lck 43 9
LKB1 64 4
MAPKAP-K2 98 4
MAPKAP-K3 91 6
MARK1 70 11
MARK2 81 10
MARK3 103 8
MARK4 101 8
MEKK1 46 1
MELK 42 9
MINK1 69 12
MKK1 96 2
MKK2 86 7
MKK6 94 14
MLK1 78 4
MLK3 84 3
MNK1 97 9
MNK2 120 5
MSK1 59 3
MST2 16 0
MST4 50 0
NEK2a 108 2
NEK6 103 5
NUAK1 40 4
p38 alpha MAPK 101 9
p38 beta MAPK 87 1
p38 delta MAPK 97 4
p38 gamma MAPK 77 2
PAK2 44 6
PAK4 69 5
PAK5 62 3
PAK6 71 12
PDK1 105 0
PHK 43 0
PIM1 54 7
PIM2 94 1
PIM3 53 13
PKA 98 7
PKB alpha 105 3
PKB beta 80 8
PKC alpha 41 1
PKC zeta 104 4
PKD1 89 3
PLK1 97 2
PRAK 96 3
PRK2 80 13
RIPK2 20 0
ROCK 2 90 0
RSK1 31 1
RSK2 67 1
S6K1 95 6
SGK1 89 4
SmMLCK 51 6
Src 22 3
SRPK1 71 12
SYK 82 14
TAK1 107 3
TAO1 42 5
TBK1 87 3
TrkA 14 1
TTK 75 2
VEGFR1 56 15
YES1 11 2
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 47 2
ASK1 101 12
Aurora A
3
 0
Aurora B 42 7
BRSK1 81 9
BRSK2 80 3
BTK 53 3
CAMK1 59 9
CAMKK beta 19 2
CDK2-Cyclin A 15 4
CHK1 53 10
CHK2 18 1
CK1 delta 87 2
CK2 104 7
CLK2
3
 0
CSK 88 12
DAPK1 96 8
DYRK1A 101 5
DYRK2 87 7
DYRK3 78 4
EF2K 96 10
EPH-A2 36 7
EPH-A4 29 13
EPH-B1 36 5
EPH-B2
4
 7
EPH-B3 20 4
EPH-B4 13 0
ERK1 78 6
ERK2 103 9
ERK8
1
 1
FGF-R1 43 3
GCK 93 2
GSK3 beta 41 3
HER4 64 15
HIPK1 42 2
HIPK2 13 0
HIPK3 31 3
IGF-1R
2
 0
IKK beta 92 3
IKK epsilon 80 8
IR 14 3
IRAK4
3
 0
IRR 80 15
JAK2 80 8
JNK1 99 4
JNK2 94 5
JNK3 107 0
Lck 13 1
LKB1 62 4
MAPKAP-K2 86 2
MAPKAP-K3 77 2
MARK1 78 9
MARK2 87 5
MARK3 89 1
MARK4 118 13
MEKK1 35 0
MELK 15 5
MINK1 64 4
MKK1 85 1
MKK2 77 7
MKK6 95 2
MLK1 69 4
MLK3 77 12
MNK1 103 13
MNK2 92 11
MSK1 51 1
MST2 19 0
MST4 50 1
NEK2a 87 1
NEK6 101 3
NUAK1 37 5
p38 alpha MAPK 89 0
p38 beta MAPK 76 5
p38 delta MAPK 24 2
p38 gamma MAPK 80 6
PAK2 44 1
PAK4 67 5
PAK5 58 3
PAK6 72 5
PDK1 98 5
PHK 15 2
PIM1 49 1
PIM2 92 1
PIM3 72 4
PKA 88 0
PKB alpha 86 10
PKB beta 94 2
PKC alpha 45 7
PKC zeta 98 9
PKD1 85 1
PLK1 85 1
PRAK 94 1
PRK2 78 2
RIPK2 17 0
ROCK 2 82 3
RSK1 29 1
RSK2 64 7
S6K1 92 2
SGK1 90 1
SmMLCK 43 5
Src 20 3
SRPK1 59 6
SYK 64 2
TAK1 84 7
TAO1 33 1
TBK1 78 4
TrkA 19 8
TTK 73 9
VEGFR1 52 11
YES1 11 1
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
3
 1
Aurora A
0
 0
Aurora B
7
 1
BRSK1 41 11
BRSK2 40 1
BTK
8
 0
CAMK1 11 0
CAMKK beta 19 2
CDK2-Cyclin A
3
 1
CHK1 52 6
CHK2
4
 1
CK1 delta 68 8
CK2 85 1
CLK2
1
 0
CSK
9
 1
DAPK1 63 5
DYRK1A 61 3
DYRK2 80 3
DYRK3 43 1
EF2K 92 10
EPH-A2 13 2
EPH-A4
0
 5
EPH-B2
4
 0
EPH-B3
6
 4
EPH-B4
4
 1
ERK1 99 1
ERK2 85 8
ERK8
1
 0
FGF-R1 11 0
GCK 33 5
GSK3 beta 37 3
HER4 51 0
HIPK1
5
 1
HIPK2
5
 0
HIPK3 17 1
IGF-1R
2
 1
IKK beta 84 7
IKK epsilon 76 9
IR
1
 0
IRAK4
2
 1
IRR 52 0
JAK2 30 0
JNK1 53 9
JNK2 54 5
JNK3 54 3
Lck
5
 3
LKB1
8
 1
MAPKAP-K2 80 0
MAPKAP-K3 85 7
MARK1 58 1
MARK2 44 3
MARK3 57 2
MARK4 43 3
MEKK1
5
 1
MELK
5
 2
MINK1
8
 1
MKK1 40 2
MLK1 17 2
MLK3 51 0
MNK1 77 13
MNK2 73 3
MSK1 22 5
MST2
3
 0
MST4 17 0
NEK2a 71 4
NEK6 85 10
NUAK1
7
 0
p38 alpha MAPK 47 5
p38 beta MAPK 48 7
p38 delta MAPK
5
 1
p38 gamma MAPK 45 5
PAK2 16 2
PAK4 20 6
PAK5 22 0
PAK6 27 1
PDK1 106 8
PHK
2
 0
PIM1 11 1
PIM2 77 11
PIM3 21 1
PKA 54 2
PKB alpha 53 1
PKB beta 46 1
PKC alpha 11 2
PKC zeta 58 4
PKD1 45 5
PLK1 114 3
PRAK 96 9
PRK2 32 2
RIPK2
8
 2
ROCK 2 63 5
RSK1
6
 0
RSK2 18 7
S6K1 11 6
SGK1 41 8
SmMLCK
5
 0
Src
2
 0
SRPK1 11 3
SYK 28 7
TAK1 27 0
TBK1 93 1
TrkA
4
 1
TTK 42 4
VEGFR1 19 1
YES1
6
 0