Inhibitor | AS601245 (JNK Inhibitor V)  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	82	7
Aurora B	84	7
Aurora C	70	6
BRSK2	92	7
CAMK1	101	2
CAMKK alpha	90	11
CAMKK beta	91	7
CDK2-Cyclin A	86	6
CHK1	97	1
CHK2	95	4
CK1 delta	71	7
CK2	63	6
CSK	98	4
DYRK1A	33	3
DYRK2	12	1
DYRK3	24	3
EF2K	110	10
EPH-A2	90	14
ERK1	104	5
ERK2	91	9
ERK8	48	3
FGF-R1	109	13
GSK3 beta	2	1
HIPK2	29	3
HIPK3	61	4
IKK beta	94	6
IKK epsilon	79	1
IRR	74	0
JNK1	82	9
JNK2	73	5
JNK3	72	5
Lck	83	5
MAPKAP-K2	85	7
MAPKAP-K3	105	8
MARK3	86	9
MELK	92	3
MKK1	73	6
MNK1	68	10
MNK2	70	6
MSK1	89	12
MST2	80	4
MST4	101	13
NEK2a	83	10
NEK6	84	9
NEK7	85	7
p38 alpha MAPK	72	8
p38 beta MAPK	96	5
p38 delta MAPK	68	10
p38 gamma MAPK	78	8
PAK4	84	11
PAK5	86	11
PAK6	102	3
PDK1	102	6
PHK	85	3
PIM1	8	1
PIM2	40	5
PIM3	3	1
PKA	112	8
PKB alpha	78	4
PKB beta	95	7
PKC alpha	89	6
PKC zeta	86	4
PKD1	108	10
PLK1	106	7
PRAK	97	8
PRK2	88	12
ROCK 2	80	3
RSK1	71	6
RSK2	89	8
S6K1	96	4
SGK1	92	3
SmMLCK	90	8
Src	79	4
SRPK1	96	7
SYK	93	14
TBK1	87	3
YES1	99	13

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	70	4
Aurora B	57	5
Aurora C	48	7
BRSK2	73	6
CAMK1	106	7
CAMKK alpha	67	8
CAMKK beta	41	4
CDK2-Cyclin A	62	5
CHK1	95	9
CHK2	64	5
CK1 delta	51	6
CK2	22	3
CSK	77	6
DYRK1A	9	2
DYRK2	4	3
DYRK3	9	5
EF2K	90	5
EPH-A2	108	11
ERK1	97	3
ERK2	68	4
ERK8	12	2
FGF-R1	49	3
GSK3 beta	1	1
HIPK2	7	1
HIPK3	18	2
IKK beta	86	3
IKK epsilon	78	6
IRR	16	1
JNK1	43	4
JNK2	29	3
JNK3	40	4
Lck	68	7
MAPKAP-K2	54	3
MAPKAP-K3	96	5
MARK3	50	7
MELK	66	7
MKK1	51	6
MNK1	50	8
MNK2	39	4
MSK1	69	5
MST2	86	3
MST4	105	3
NEK2a	81	6
NEK6	63	10
NEK7	70	5
p38 alpha MAPK	63	1
p38 beta MAPK	87	8
p38 delta MAPK	28	2
p38 gamma MAPK	46	4
PAK4	38	3
PAK5	54	3
PAK6	89	11
PDK1	92	9
PHK	62	6
PIM1	5	3
PIM2	7	2
PIM3	2	0
PKA	77	8
PKB alpha	32	3
PKB beta	51	5
PKC alpha	80	7
PKC zeta	85	12
PKD1	40	11
PLK1	43	6
PRAK	67	3
PRK2	58	8
ROCK 2	32	7
RSK1	40	1
RSK2	52	6
S6K1	65	8
SGK1	69	5
SmMLCK	57	5
Src	38	3
SRPK1	72	1
SYK	92	11
TBK1	67	2
YES1	57	8