Protein transformations that change lives

Inhibitor | Amlexanox

Compound name	Brutto	MW	CAS	PubChem CID	Action	Reference	Reference
Amlexanox	C₁₆H₁₄N₂O₄	298.29	68302-57-8	2161	TBK1, IKKe

Screen Conc: 1.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	106	23
AMPK	111	24
AMPK (hum)	89	8
ASK1	112	21
Aurora A	98	7
Aurora B	83	9
BRK	66	7
BRSK1	110	3
BRSK2	102	5
BTK	84	5
CAMK1	108	25
CAMKK beta	94	4
CDK2-Cyclin A	92	8
CDK9-Cyclin T1	108	3
CHK1	107	2
CHK2	47	4
CK1 delta	90	3
CK1 gamma 2	77	4
CK2	84	14
CLK2	91	12
CSK	92	12
DAPK1	79	6
DDR2	112	13
DYRK1A	74	5
DYRK2	101	16
DYRK3	96	1
EF2K	104	10
EIF2AK3	93	7
EPH-A2	104	16
EPH-A4	97	8
EPH-B1	91	5
EPH-B2	118	19
EPH-B3	74	7
EPH-B4	101	2
ERK1	109	15
ERK2	86	10
ERK5	99	2
ERK8	92	11
FGF-R1	102	13
GCK	91	6
GSK3 beta	102	2
HER4	95	4
HIPK1	79	0
HIPK2	102	11
HIPK3	90	3
IGF-1R	68	7
IKK beta	104	12
IKK epsilon	84	16
IR	98	4
IRAK1	98	2
IRAK4	98	4
IRR	85	1
JAK2	113	0
JNK1	84	2
JNK2	96	11
JNK3	94	1
Lck	106	0
LKB1	96	8
MAP4K3	84	0
MAP4K5	65	8
MAPKAP-K2	97	10
MAPKAP-K3	84	8
MARK1	87	12
MARK2	88	0
MARK3	86	10
MARK4	96	11
MEKK1	100	8
MELK	91	7
MINK1	85	3
MKK1	97	2
MKK2	90	3
MKK6	77	1
MLK1	18	1
MLK3	10	0
MNK1	94	4
MNK2	89	0
MPSK1	98	7
MSK1	111	2
MST2	85	1
MST3	73	6
MST4	82	6
NEK2a	92	8
NEK6	103	1
NUAK1	116	12
OSR1	105	8
p38 alpha MAPK	119	3
p38 beta MAPK	99	5
p38 delta MAPK	95	2
p38 gamma MAPK	104	1
PAK2	105	8
PAK4	82	13
PAK5	93	4
PAK6	105	2
PDGFRA	106	2
PDK1	96	11
PHK	108	4
PIM1	91	7
PIM2	105	9
PIM3	53	4
PINK	96	2
PKA	97	2
PKB alpha	98	4
PKB beta	87	0
PKC alpha	91	10
PKC gamma	89	11
PKC zeta	102	6
PKD1	115	16
PLK1	98	3
PRAK	87	18
PRK2	106	3
RIPK2	94	3
ROCK 2	74	7
RSK1	87	5
RSK2	95	7
S6K1	79	10
SGK1	93	8
SIK2	87	8
SIK3	97	3
SmMLCK	53	7
Src	103	3
SRPK1	58	3
STK33	94	11
SYK	81	12
TAK1	103	13
TAO1	90	0
TBK1	73	9
TESK1	79	8
TGFBR1	110	16
TIE2	78	2
TLK1	106	4
TrkA	80	9
TSSK1	96	5
TTBK1	95	3
TTBK2	98	7
TTK	82	2
ULK1	77	6
ULK2	98	11
VEGFR1	49	4
WNK1	107	6
YES1	74	7
ZAP70	98	4

Screen Conc: 10.00µM
Kinase	% Activity Remaining	Standard Deviation
ABL	86	12
AMPK	113	16
AMPK (hum)	55	5
ASK1	116	6
Aurora A	110	8
Aurora B	93	15
BRK	66	4
BRSK1	91	7
BRSK2	87	2
BTK	51	6
CAMK1	66	10
CAMKK beta	40	1
CDK2-Cyclin A	85	11
CDK9-Cyclin T1	97	0
CHK1	113	1
CHK2	12	0
CK1 delta	85	4
CK1 gamma 2	36	0
CK2	65	3
CLK2	88	12
CSK	81	7
DAPK1	43	12
DDR2	90	4
DYRK1A	69	2
DYRK2	79	17
DYRK3	93	7
EF2K	102	12
EIF2AK3	108	1
EPH-A2	98	9
EPH-A4	71	3
EPH-B1	102	1
EPH-B2	105	3
EPH-B3	95	13
EPH-B4	88	6
ERK1	101	22
ERK2	96	4
ERK5	95	1
ERK8	79	4
FGF-R1	96	13
GCK	87	2
GSK3 beta	96	10
HER4	73	8
HIPK1	82	1
HIPK2	93	23
HIPK3	93	4
IGF-1R	31	0
IKK beta	96	8
IKK epsilon	28	4
IR	36	2
IRAK1	83	2
IRAK4	97	16
IRR	53	1
JAK2	74	0
JNK1	104	0
JNK2	98	3
JNK3	98	1
Lck	102	10
LKB1	122	30
MAP4K3	79	6
MAP4K5	46	0
MAPKAP-K2	84	8
MAPKAP-K3	74	10
MARK1	95	14
MARK2	94	4
MARK3	100	12
MARK4	85	6
MEKK1	102	16
MELK	64	14
MINK1	89	16
MKK1	102	12
MKK2	93	0
MKK6	103	8
MLK1	6	2
MLK3	5	0
MNK1	73	11
MNK2	91	4
MPSK1	99	6
MSK1	103	3
MST2	84	4
MST3	92	11
MST4	89	11
NEK2a	97	10
NEK6	108	0
NUAK1	91	8
OSR1	103	8
p38 alpha MAPK	103	9
p38 beta MAPK	94	1
p38 delta MAPK	91	5
p38 gamma MAPK	93	5
PAK2	109	2
PAK4	98	3
PAK5	102	7
PAK6	110	3
PDGFRA	84	12
PDK1	102	16
PHK	95	1
PIM1	67	1
PIM2	112	15
PIM3	14	0
PINK	102	10
PKA	98	6
PKB alpha	91	2
PKB beta	82	8
PKC alpha	98	4
PKC gamma	83	5
PKC zeta	85	8
PKD1	102	13
PLK1	92	3
PRAK	88	1
PRK2	113	25
RIPK2	56	2
ROCK 2	86	13
RSK1	70	1
RSK2	90	2
S6K1	69	2
SGK1	79	1
SIK2	84	2
SIK3	100	3
SmMLCK	13	1
Src	85	6
SRPK1	16	1
STK33	79	5
SYK	79	10
TAK1	86	6
TAO1	109	6
TBK1	22	0
TESK1	86	6
TGFBR1	98	10
TIE2	85	2
TLK1	109	2
TrkA	49	7
TSSK1	86	2
TTBK1	107	12
TTBK2	86	8
TTK	67	0
ULK1	93	8
ULK2	89	7
VEGFR1	15	0
WNK1	105	0
YES1	94	10
ZAP70	109	7