

Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
Amgen TBK 1 inhibitor (Compound II) | C28H35N7O4 | 533.62 | TBK1 | Ou Y.H. (2011) Molecular Cell 41 458-470 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL | 31 | 2 |
AMPK | 25 | 4 |
ASK1 | 99 | 3 |
Aurora A | 18 | 3 |
Aurora B | 36 | 1 |
BRK | 46 | 4 |
BRSK1 | 74 | 2 |
BRSK2 | 84 | 5 |
BTK | 22 | 2 |
CAMK1 | 67 | 2 |
CAMKK beta | 58 | 4 |
CDK2-Cyclin A | 34 | 2 |
CHK1 | 72 | 0 |
CHK2 | 48 | 0 |
CK1 delta | 95 | 1 |
CK2 | 33 | 2 |
CLK2 | 30 | 10 |
CSK | 65 | 5 |
DAPK1 | 51 | 5 |
DYRK1A | 57 | 3 |
DYRK2 | 50 | 5 |
DYRK3 | 75 | 30 |
EF2K | 100 | 13 |
EIF2AK3 | 90 | 20 |
EPH-A2 | 28 | 12 |
EPH-A4 | 14 | 0 |
EPH-B1 |
8
|
0 |
EPH-B2 | 23 | 11 |
EPH-B3 | 86 | 16 |
EPH-B4 | 69 | 13 |
ERK1 | 111 | 12 |
ERK2 | 84 | 13 |
ERK8 | 22 | 6 |
FGF-R1 | 20 | 1 |
GCK | 29 | 9 |
GSK3 beta | 37 | 6 |
HER4 | 60 | 4 |
HIPK1 | 44 | 13 |
HIPK2 | 31 | 11 |
HIPK3 | 69 | 12 |
IGF-1R | 104 | 19 |
IKK beta | 86 | 8 |
IKK epsilon | 28 | 6 |
IR | 79 | 4 |
IRAK1 | 19 | 3 |
IRAK4 | 64 | 11 |
IRR | 78 | 9 |
JAK2 |
4
|
0 |
JNK1 | 89 | 13 |
JNK2 | 85 | 21 |
JNK3 | 65 | 13 |
Lck |
10
|
2 |
LKB1 | 119 | 14 |
MAPKAP-K2 | 105 | 25 |
MAPKAP-K3 | 97 | 3 |
MARK1 | 63 | 6 |
MARK2 | 67 | 4 |
MARK3 | 41 | 9 |
MARK4 | 92 | 24 |
MEKK1 | 103 | 7 |
MELK | 37 | 0 |
MINK1 | 104 | 14 |
MKK1 | 40 | 8 |
MKK2 | 55 | 7 |
MKK6 | 99 | 5 |
MLK1 |
7
|
1 |
MLK3 | 15 | 5 |
MNK1 | 59 | 5 |
MNK2 | 67 | 9 |
MPSK1 | 101 | 1 |
MSK1 | 76 | 8 |
MST2 | 78 | 5 |
MST4 | 90 | 18 |
NEK2a | 22 | 2 |
NEK6 | 89 | 2 |
NUAK1 | 16 | 2 |
OSR1 | 101 | 14 |
p38 alpha MAPK | 98 | 4 |
p38 beta MAPK | 103 | 2 |
p38 delta MAPK | 93 | 21 |
p38 gamma MAPK | 113 | 16 |
PAK2 | 50 | 14 |
PAK4 | 29 | 1 |
PAK5 | 53 | 0 |
PAK6 | 62 | 8 |
PDK1 | 96 | 4 |
PHK | 56 | 1 |
PIM1 | 96 | 17 |
PIM2 | 108 | 16 |
PIM3 | 91 | 6 |
PKA | 78 | 11 |
PKB alpha | 99 | 12 |
PKB beta | 88 | 17 |
PKC alpha | 95 | 15 |
PKC gamma | 117 | 7 |
PKC zeta | 94 | 21 |
PKD1 | 100 | 0 |
PLK1 | 90 | 11 |
PRAK | 98 | 12 |
PRK2 | 57 | 3 |
RIPK2 | 28 | 5 |
ROCK 2 | 49 | 5 |
RSK1 | 62 | 44 |
RSK2 | 38 | 1 |
S6K1 | 70 | 15 |
SGK1 | 107 | 10 |
SmMLCK | 100 | 6 |
Src |
7
|
1 |
SRPK1 | 104 | 4 |
STK33 | 30 | 2 |
SYK | 58 | 7 |
TAK1 | 14 | 3 |
TAO1 | 95 | 7 |
TBK1 | 14 | 0 |
TESK1 | 59 | 10 |
TIE2 | 60 | 4 |
TLK1 | 79 | 1 |
TrkA | 32 | 4 |
TSSK1 | 31 | 7 |
TTBK1 | 104 | 11 |
TTK | 81 | 1 |
VEGFR1 |
5
|
1 |
YES1 | 16 | 9 |
ZAP70 | 54 | 1 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
ABL |
7
|
3 |
AMPK | 22 | 0 |
ASK1 | 77 | 5 |
Aurora A |
3
|
1 |
Aurora B | 11 | 3 |
BRK |
6
|
1 |
BRSK1 | 17 | 1 |
BRSK2 | 35 | 7 |
BTK | 14 | 1 |
CAMK1 | 26 | 2 |
CAMKK beta | 28 | 1 |
CDK2-Cyclin A |
7
|
1 |
CHK1 | 20 | 1 |
CHK2 | 12 | 2 |
CK1 delta | 69 | 8 |
CK2 |
6
|
5 |
CLK2 | 11 | 4 |
CSK | 38 | 15 |
DAPK1 | 15 | 1 |
DYRK1A | 12 | 1 |
DYRK2 | 16 | 2 |
DYRK3 |
10
|
2 |
EF2K | 91 | 5 |
EIF2AK3 | 31 | 0 |
EPH-A2 | 32 | 26 |
EPH-A4 |
5
|
1 |
EPH-B1 |
3
|
1 |
EPH-B2 |
6
|
2 |
EPH-B3 | 16 | 4 |
EPH-B4 |
3
|
0 |
ERK1 | 82 | 0 |
ERK2 | 57 | 5 |
ERK8 |
4
|
1 |
FGF-R1 |
8
|
4 |
GCK | 56 | 22 |
GSK3 beta |
6
|
1 |
HER4 | 17 | 1 |
HIPK1 | 17 | 4 |
HIPK2 |
10
|
1 |
HIPK3 | 19 | 0 |
IGF-1R |
6
|
1 |
IKK beta | 55 | 6 |
IKK epsilon | 18 | 4 |
IR | 21 | 7 |
IRAK1 |
5
|
2 |
IRAK4 | 20 | 1 |
IRR | 35 | 3 |
JAK2 |
3
|
1 |
JNK1 | 38 | 0 |
JNK2 | 33 | 1 |
JNK3 | 39 | 0 |
Lck |
4
|
0 |
LKB1 | 73 | 2 |
MAPKAP-K2 | 108 | 5 |
MAPKAP-K3 | 81 | 12 |
MARK1 | 31 | 14 |
MARK2 | 28 | 9 |
MARK3 | 16 | 1 |
MARK4 | 24 | 5 |
MEKK1 | 92 | 9 |
MELK | 27 | 4 |
MINK1 | 57 | 5 |
MKK1 | 13 | 2 |
MKK2 | 28 | 4 |
MKK6 | 75 | 4 |
MLK1 |
6
|
0 |
MLK3 |
8
|
0 |
MNK1 | 17 | 0 |
MNK2 | 17 | 5 |
MPSK1 | 42 | 5 |
MSK1 | 34 | 4 |
MST2 | 61 | 39 |
MST4 | 67 | 2 |
NEK2a |
3
|
1 |
NEK6 | 59 | 5 |
NUAK1 | 13 | 1 |
OSR1 | 71 | 4 |
p38 alpha MAPK | 85 | 12 |
p38 beta MAPK | 95 | 14 |
p38 delta MAPK | 68 | 2 |
p38 gamma MAPK | 95 | 1 |
PAK2 | 14 | 1 |
PAK4 |
9
|
0 |
PAK5 | 18 | 0 |
PAK6 | 24 | 2 |
PDK1 | 36 | 3 |
PHK | 12 | 1 |
PIM1 | 62 | 0 |
PIM2 | 106 | 6 |
PIM3 | 63 | 4 |
PKA | 26 | 5 |
PKB alpha | 89 | 7 |
PKB beta | 77 | 0 |
PKC alpha | 56 | 9 |
PKC gamma | 71 | 19 |
PKC zeta | 78 | 5 |
PKD1 | 48 | 6 |
PLK1 | 91 | 7 |
PRAK | 85 | 1 |
PRK2 | 27 | 4 |
RIPK2 | 14 | 1 |
ROCK 2 | 25 | 5 |
RSK1 |
7
|
0 |
RSK2 |
9
|
1 |
S6K1 | 28 | 3 |
SGK1 | 61 | 1 |
SmMLCK | 72 | 11 |
Src |
3
|
0 |
SRPK1 | 87 | 1 |
STK33 | 23 | 3 |
SYK | 13 | 0 |
TAK1 | 19 | 12 |
TAO1 | 74 | 8 |
TBK1 |
8
|
1 |
TESK1 | 24 | 5 |
TIE2 | 11 | 4 |
TLK1 | 39 | 0 |
TrkA | 11 | 1 |
TSSK1 |
5
|
0 |
TTBK1 | 102 | 8 |
TTK | 64 | 4 |
VEGFR1 |
2
|
0 |
YES1 |
7
|
2 |
ZAP70 | 22 | 4 |