Inhibitor | Amgen TBK 1 inhibitor (Compound II)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen TBK 1 inhibitor (Compound II)   C28H35N7O4 533.62 TBK1 Ou Y.H. (2011) Molecular Cell 41 458-470 https://pubmed.ncbi.nlm.nih.gov/[pmid2]

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 31 2
AMPK 25 4
ASK1 99 3
Aurora A 18 3
Aurora B 36 1
BRK 46 4
BRSK1 74 2
BRSK2 84 5
BTK 22 2
CAMK1 67 2
CAMKK beta 58 4
CDK2-Cyclin A 34 2
CHK1 72 0
CHK2 48 0
CK1 delta 95 1
CK2 33 2
CLK2 30 10
CSK 65 5
DAPK1 51 5
DYRK1A 57 3
DYRK2 50 5
DYRK3 75 30
EF2K 100 13
EIF2AK3 90 20
EPH-A2 28 12
EPH-A4 14 0
EPH-B1
8
0
EPH-B2 23 11
EPH-B3 86 16
EPH-B4 69 13
ERK1 111 12
ERK2 84 13
ERK8 22 6
FGF-R1 20 1
GCK 29 9
GSK3 beta 37 6
HER4 60 4
HIPK1 44 13
HIPK2 31 11
HIPK3 69 12
IGF-1R 104 19
IKK beta 86 8
IKK epsilon 28 6
IR 79 4
IRAK1 19 3
IRAK4 64 11
IRR 78 9
JAK2
4
0
JNK1 89 13
JNK2 85 21
JNK3 65 13
Lck
10
2
LKB1 119 14
MAPKAP-K2 105 25
MAPKAP-K3 97 3
MARK1 63 6
MARK2 67 4
MARK3 41 9
MARK4 92 24
MEKK1 103 7
MELK 37 0
MINK1 104 14
MKK1 40 8
MKK2 55 7
MKK6 99 5
MLK1
7
1
MLK3 15 5
MNK1 59 5
MNK2 67 9
MPSK1 101 1
MSK1 76 8
MST2 78 5
MST4 90 18
NEK2a 22 2
NEK6 89 2
NUAK1 16 2
OSR1 101 14
p38 alpha MAPK 98 4
p38 beta MAPK 103 2
p38 delta MAPK 93 21
p38 gamma MAPK 113 16
PAK2 50 14
PAK4 29 1
PAK5 53 0
PAK6 62 8
PDK1 96 4
PHK 56 1
PIM1 96 17
PIM2 108 16
PIM3 91 6
PKA 78 11
PKB alpha 99 12
PKB beta 88 17
PKC alpha 95 15
PKC gamma 117 7
PKC zeta 94 21
PKD1 100 0
PLK1 90 11
PRAK 98 12
PRK2 57 3
RIPK2 28 5
ROCK 2 49 5
RSK1 62 44
RSK2 38 1
S6K1 70 15
SGK1 107 10
SmMLCK 100 6
Src
7
1
SRPK1 104 4
STK33 30 2
SYK 58 7
TAK1 14 3
TAO1 95 7
TBK1 14 0
TESK1 59 10
TIE2 60 4
TLK1 79 1
TrkA 32 4
TSSK1 31 7
TTBK1 104 11
TTK 81 1
VEGFR1
5
1
YES1 16 9
ZAP70 54 1
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL
7
3
AMPK 22 0
ASK1 77 5
Aurora A
3
1
Aurora B 11 3
BRK
6
1
BRSK1 17 1
BRSK2 35 7
BTK 14 1
CAMK1 26 2
CAMKK beta 28 1
CDK2-Cyclin A
7
1
CHK1 20 1
CHK2 12 2
CK1 delta 69 8
CK2
6
5
CLK2 11 4
CSK 38 15
DAPK1 15 1
DYRK1A 12 1
DYRK2 16 2
DYRK3
10
2
EF2K 91 5
EIF2AK3 31 0
EPH-A2 32 26
EPH-A4
5
1
EPH-B1
3
1
EPH-B2
6
2
EPH-B3 16 4
EPH-B4
3
0
ERK1 82 0
ERK2 57 5
ERK8
4
1
FGF-R1
8
4
GCK 56 22
GSK3 beta
6
1
HER4 17 1
HIPK1 17 4
HIPK2
10
1
HIPK3 19 0
IGF-1R
6
1
IKK beta 55 6
IKK epsilon 18 4
IR 21 7
IRAK1
5
2
IRAK4 20 1
IRR 35 3
JAK2
3
1
JNK1 38 0
JNK2 33 1
JNK3 39 0
Lck
4
0
LKB1 73 2
MAPKAP-K2 108 5
MAPKAP-K3 81 12
MARK1 31 14
MARK2 28 9
MARK3 16 1
MARK4 24 5
MEKK1 92 9
MELK 27 4
MINK1 57 5
MKK1 13 2
MKK2 28 4
MKK6 75 4
MLK1
6
0
MLK3
8
0
MNK1 17 0
MNK2 17 5
MPSK1 42 5
MSK1 34 4
MST2 61 39
MST4 67 2
NEK2a
3
1
NEK6 59 5
NUAK1 13 1
OSR1 71 4
p38 alpha MAPK 85 12
p38 beta MAPK 95 14
p38 delta MAPK 68 2
p38 gamma MAPK 95 1
PAK2 14 1
PAK4
9
0
PAK5 18 0
PAK6 24 2
PDK1 36 3
PHK 12 1
PIM1 62 0
PIM2 106 6
PIM3 63 4
PKA 26 5
PKB alpha 89 7
PKB beta 77 0
PKC alpha 56 9
PKC gamma 71 19
PKC zeta 78 5
PKD1 48 6
PLK1 91 7
PRAK 85 1
PRK2 27 4
RIPK2 14 1
ROCK 2 25 5
RSK1
7
0
RSK2
9
1
S6K1 28 3
SGK1 61 1
SmMLCK 72 11
Src
3
0
SRPK1 87 1
STK33 23 3
SYK 13 0
TAK1 19 12
TAO1 74 8
TBK1
8
1
TESK1 24 5
TIE2 11 4
TLK1 39 0
TrkA 11 1
TSSK1
5
0
TTBK1 102 8
TTK 64 4
VEGFR1
2
0
YES1
7
2
ZAP70 22 4