Inhibitor | Amgen-NIK-28  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Amgen-NIK-28   C20H20N4O 332.40 NIK Li K. (2013) Bioorganic and Medicinal Chemistry Letters 23 1238-1244

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 104 13
AMPK (hum) 109 14
ASK1 110 1
Aurora A 102 5
Aurora B 90 5
BRK 98 4
BRSK1 94 1
BRSK2 101 0
BTK 113 2
CAMK1 98 19
CAMKK beta 94 7
CDK2-Cyclin A 101 1
CDK9-Cyclin T1 100 3
CHK1 105 3
CHK2 65 5
CK1 delta 45 6
CK1 gamma 2 103 3
CK2 100 9
CLK2 73 3
CSK 124 3
DAPK1 97 14
DDR2 92 10
DYRK1A 93 12
DYRK2 91 0
DYRK3 88 6
EF2K 97 4
EIF2AK3 71 7
EPH-A2 82 7
EPH-A4 106 21
EPH-B1 105 6
EPH-B2 124 7
EPH-B3 87 2
EPH-B4 89 2
ERK1 97 8
ERK2 115 5
ERK5 81 2
ERK8 96 0
FGF-R1 101 14
GCK 99 0
GSK3 beta 85 2
HER4 104 4
HIPK1
7
 0
HIPK2 77 5
HIPK3 100 1
IGF-1R 106 21
IKK beta 95 18
IKK epsilon 87 5
IR 96 8
IRAK1 103 8
IRAK4 75 6
IRR 116 6
JAK2 39 4
JNK1 86 4
JNK2 85 12
JNK3 93 14
Lck 97 5
LKB1 92 15
MAP4K3 11 3
MAP4K5
5
 0
MAPKAP-K2 108 10
MAPKAP-K3 94 21
MARK1 76 16
MARK2 72 4
MARK3 41 6
MARK4 79 0
MEKK1 96 1
MELK 87 13
MINK1 58 4
MKK1 57 3
MKK2 75 6
MKK6 79 16
MLK1 30 4
MLK3 12 1
MNK1 89 0
MNK2 95 1
MPSK1 104 0
MSK1 105 13
MST2 99 1
MST3 99 2
MST4 107 1
NEK2a 105 3
NEK6 103 21
NUAK1 77 6
OSR1 83 1
p38 alpha MAPK 117 13
p38 beta MAPK 95 5
p38 delta MAPK 86 1
p38 gamma MAPK 76 0
PAK2 110 2
PAK4 13 3
PAK5 16 1
PAK6 29 1
PDGFRA 88 4
PDK1 111 11
PHK 97 5
PIM1 108 3
PIM2 115 10
PIM3 109 0
PINK 110 6
PKA 102 1
PKB alpha 91 1
PKB beta 90 2
PKC alpha 102 15
PKC gamma 105 3
PKC zeta 93 5
PKD1 42 1
PLK1 104 16
PRAK 109 12
PRK2 95 3
RIPK2 88 4
ROCK 2 97 1
RSK1 83 20
RSK2 89 5
S6K1 97 12
SGK1 110 1
SIK2 81 3
SIK3 103 13
SmMLCK 85 1
Src 107 0
SRPK1 97 10
STK33 87 8
SYK 108 4
TAK1 29 1
TAO1 30 0
TBK1 104 2
TESK1 105 3
TGFBR1 83 1
TIE2 113 11
TLK1 101 4
TrkA 127 6
TSSK1 49 2
TTBK1 47 10
TTBK2 52 10
TTK 109 0
ULK1 89 14
ULK2 79 13
VEGFR1 67 5
WNK1 107 3
YES1 118 8
ZAP70 98 3
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 95 7
AMPK (hum) 71 5
ASK1 101 6
Aurora A 107 1
Aurora B 72 3
BRK 87 4
BRSK1 91 5
BRSK2 84 7
BTK 117 21
CAMK1 69 12
CAMKK beta 99 2
CDK2-Cyclin A 97 21
CDK9-Cyclin T1 126 1
CHK1 102 5
CHK2 16 3
CK1 delta 15 3
CK1 gamma 2 92 1
CK2 90 3
CLK2 27 5
CSK 119 19
DAPK1 82 1
DDR2 104 4
DYRK1A 72 13
DYRK2 76 1
DYRK3 61 2
EF2K 83 9
EIF2AK3 24 4
EPH-A2 90 2
EPH-A4 119 30
EPH-B1 101 11
EPH-B2 131 16
EPH-B3 87 3
EPH-B4 98 1
ERK1 96 6
ERK2 95 5
ERK5 47 3
ERK8 85 0
FGF-R1 62 2
GCK 37 1
GSK3 beta 30 2
HER4 108 10
HIPK1
3
 0
HIPK2 39 2
HIPK3 86 26
IGF-1R 118 8
IKK beta 82 4
IKK epsilon 28 10
IR 72 5
IRAK1 97 7
IRAK4 53 10
IRR 103 9
JAK2
10
 2
JNK1 86 17
JNK2 86 6
JNK3 89 10
Lck 94 6
LKB1 81 6
MAP4K3
2
 1
MAP4K5
5
 1
MAPKAP-K2 108 10
MAPKAP-K3 104 7
MARK1 38 15
MARK2 42 1
MARK3
10
 1
MARK4 39 3
MEKK1 94 2
MELK 71 2
MINK1 16 0
MKK1 22 2
MKK2 39 7
MKK6 46 24
MLK1
5
 0
MLK3
2
 0
MNK1 108 4
MNK2 92 1
MPSK1 89 7
MSK1 102 7
MST2 65 2
MST3 72 2
MST4 63 3
NEK2a 92 5
NEK6 92 13
NUAK1 33 3
OSR1 88 8
p38 alpha MAPK 113 7
p38 beta MAPK 100 0
p38 delta MAPK 88 6
p38 gamma MAPK 34 1
PAK2 96 11
PAK4
2
 2
PAK5
3
 1
PAK6
5
 1
PDGFRA 96 13
PDK1 101 1
PHK 80 3
PIM1 92 5
PIM2 108 7
PIM3 89 3
PINK 102 4
PKA 89 2
PKB alpha 54 1
PKB beta 46 4
PKC alpha 102 7
PKC gamma 97 2
PKC zeta 89 8
PKD1
9
 3
PLK1 103 1
PRAK 103 10
PRK2 86 6
RIPK2 73 5
ROCK 2 94 1
RSK1 81 15
RSK2 94 4
S6K1 101 8
SGK1 68 0
SIK2 77 5
SIK3 87 10
SmMLCK 31 0
Src 82 10
SRPK1 94 17
STK33 52 0
SYK 117 7
TAK1
6
 0
TAO1
7
 2
TBK1 90 5
TESK1 97 4
TGFBR1 84 9
TIE2 97 12
TLK1 99 17
TrkA 115 11
TSSK1 13 0
TTBK1
8
 1
TTBK2 12 5
TTK 100 1
ULK1 81 16
ULK2 61 7
VEGFR1 22 2
WNK1 103 15
YES1 107 14
ZAP70 103 11