Inhibitor | BAY 61-3606  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	100	6
AMPK	87	3
AMPK (hum)	89	12
ASK1	82	7
Aurora A	110	12
Aurora B	40	3
BRK	89	1
BRSK1	89	11
BRSK2	77	10
BTK	59	1
CAMK1	101	3
CAMKK beta	37	8
CDK2-Cyclin A	25	3
CDK9-Cyclin T1	26	7
CHK1	91	18
CHK2	68	3
CK1 delta	72	4
CK1 gamma 2	92	4
CK2	96	9
CLK2	14	1
CSK	85	8
DAPK1	77	9
DDR2	93	1
DYRK1A	51	0
DYRK2	40	0
DYRK3	24	2
EF2K	71	1
EIF2AK3	95	2
EPH-A2	96	15
EPH-A4	88	10
EPH-B1	78	2
EPH-B2	87	1
EPH-B3	89	1
EPH-B4	89	8
ERK1	69	7
ERK2	68	7
ERK5	67	1
ERK8	55	23
FGF-R1	69	11
GCK	4	1
GSK3 beta	15	5
HER4	103	2
HIPK1	62	12
HIPK2	25	1
HIPK3	71	2
IGF-1R	10	4
IKK beta	56	4
IKK epsilon	51	1
IR	16	1
IRAK1	31	0
IRAK4	78	9
IRR	29	2
JAK2	69	7
JNK1	85	3
JNK2	72	11
JNK3	73	11
Lck	74	8
LKB1	50	5
MAP4K3	34	4
MAP4K5	56	5
MAPKAP-K2	99	4
MAPKAP-K3	95	21
MARK1	89	2
MARK2	56	5
MARK3	49	7
MARK4	64	3
MEKK1	88	10
MELK	63	13
MINK1	78	7
MKK1	82	6
MKK2	80	6
MKK6	62	3
MLK1	36	2
MLK3	20	1
MNK1	83	4
MNK2	69	11
MPSK1	98	24
MSK1	74	5
MST2	50	8
MST3	75	10
MST4	83	5
NEK2a	79	7
NEK6	99	17
NUAK1	26	1
OSR1	93	13
p38 alpha MAPK	103	10
p38 beta MAPK	71	2
p38 delta MAPK	87	0
p38 gamma MAPK	76	8
PAK2	89	1
PAK4	74	7
PAK5	74	2
PAK6	82	3
PDGFRA	40	1
PDK1	94	3
PHK	84	12
PIM1	59	9
PIM2	83	9
PIM3	70	41
PKA	84	2
PKB alpha	92	6
PKB beta	106	19
PKC alpha	56	1
PKC gamma	99	4
PKC zeta	76	5
PKD1	27	1
PLK1	79	9
PRAK	101	7
PRK2	32	3
RIPK2	32	0
ROCK 2	18	0
RSK1	102	21
RSK2	117	3
S6K1	75	4
SGK1	100	1
SIK2	75	2
SIK3	90	4
SmMLCK	111	10
Src	54	12
SRPK1	81	1
STK33	75	5
SYK	36	2
TAK1	16	1
TAO1	75	2
TBK1	85	13
TESK1	75	7
TGFBR1	98	7
TIE2	105	0
TLK1	80	12
TrkA	80	30
TSSK1	65	17
TTBK1	93	19
TTBK2	98	10
TTK	74	10
ULK1	73	1
ULK2	96	4
VEGFR1	71	15
WNK1	95	9
YES1	63	15
ZAP70	79	7

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	91	9
AMPK	101	2
AMPK (hum)	59	35
ASK1	77	0
Aurora A	114	17
Aurora B	48	1
BRK	73	14
BRSK1	86	2
BRSK2	78	12
BTK	46	1
CAMK1	100	11
CAMKK beta	43	3
CDK2-Cyclin A	23	1
CDK9-Cyclin T1	21	9
CHK1	108	12
CHK2	83	5
CK1 delta	75	2
CK1 gamma 2	93	11
CK2	93	9
CLK2	12	2
CSK	88	9
DAPK1	74	1
DDR2	92	9
DYRK1A	58	1
DYRK2	36	2
DYRK3	24	4
EF2K	90	3
EIF2AK3	82	1
EPH-A2	76	5
EPH-A4	78	1
EPH-B1	86	2
EPH-B2	86	3
EPH-B3	99	8
EPH-B4	93	2
ERK1	71	12
ERK2	65	7
ERK5	67	4
ERK8	39	7
FGF-R1	67	15
GCK	5	1
GSK3 beta	16	2
HER4	84	4
HIPK1	56	6
HIPK2	24	8
HIPK3	73	4
IGF-1R	6	1
IKK beta	55	2
IKK epsilon	60	9
IR	13	1
IRAK1	31	3
IRAK4	68	8
IRR	25	4
JAK2	58	7
JNK1	94	3
JNK2	75	9
JNK3	62	5
Lck	76	1
LKB1	59	0
MAP4K3	29	4
MAP4K5	52	0
MAPKAP-K2	146	51
MAPKAP-K3	82	5
MARK1	89	5
MARK2	69	10
MARK3	44	2
MARK4	74	12
MEKK1	82	2
MELK	71	6
MINK1	59	4
MKK1	92	10
MKK2	83	18
MKK6	55	2
MLK1	33	3
MLK3	22	4
MNK1	73	0
MNK2	56	1
MPSK1	103	13
MSK1	81	4
MST2	55	3
MST3	79	1
MST4	78	16
NEK2a	82	7
NEK6	82	10
NUAK1	1	0
OSR1	89	11
p38 alpha MAPK	107	10
p38 beta MAPK	84	11
p38 delta MAPK	85	3
p38 gamma MAPK	84	13
PAK2	102	6
PAK4	75	12
PAK5	71	3
PAK6	80	9
PDGFRA	38	5
PDK1	94	17
PHK	80	4
PIM1	69	1
PIM2	81	10
PIM3	45	2
PKA	99	12
PKB alpha	106	12
PKB beta	79	15
PKC alpha	46	1
PKC gamma	103	12
PKC zeta	85	7
PKD1	29	6
PLK1	86	12
PRAK	103	18
PRK2	21	3
RIPK2	29	1
ROCK 2	14	1
RSK1	82	7
RSK2	113	12
S6K1	75	7
SGK1	89	6
SIK2	72	2
SIK3	79	2
SmMLCK	94	16
Src	63	6
SRPK1	82	3
STK33	66	2
SYK	32	1
TAK1	14	0
TAO1	69	5
TBK1	78	8
TESK1	84	2
TGFBR1	94	2
TIE2	113	2
TLK1	93	4
TrkA	92	47
TSSK1	88	14
TTBK1	87	10
TTBK2	98	2
TTK	71	1
ULK1	68	5
ULK2	91	14
VEGFR1	50	9
WNK1	96	7
YES1	51	15
ZAP70	82	5