Inhibitor | AX 20017  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	93	1
AMPK	103	11
ASK1	106	8
Aurora A	87	6
Aurora B	79	4
BRK	114	1
BRSK1	97	3
BRSK2	99	6
BTK	90	2
CAMK1	98	3
CAMKK beta	106	7
CDK2-Cyclin A	89	3
CHK1	95	3
CHK2	74	7
CK1 delta	96	10
CK2	94	22
CLK2	89	5
CSK	96	2
DAPK1	102	2
DYRK1A	85	4
DYRK2	109	2
DYRK3	111	9
EF2K	97	9
EPH-A2	87	9
EPH-A4	114	13
EPH-B1	117	14
EPH-B2	104	12
EPH-B3	115	5
EPH-B4	101	1
ERK1	107	15
ERK2	99	1
ERK8	106	1
FGF-R1	105	6
GCK	69	2
GSK3 beta	90	8
HER4	106	4
HIPK1	100	16
HIPK2	94	9
HIPK3	89	6
IGF-1R	86	1
IKK beta	100	4
IKK epsilon	211	147
IR	101	8
IRAK4	68	5
IRR	97	5
JAK2	104	6
JNK1	97	3
JNK2	106	5
JNK3	94	3
Lck	98	13
LKB1	91	7
MAPKAP-K2	98	15
MAPKAP-K3	100	2
MARK1	93	9
MARK2	97	5
MARK3	90	3
MARK4	105	0
MEKK1	124	42
MELK	71	16
MINK1	80	7
MKK1	92	2
MKK2	93	3
MKK6	109	2
MLK1	72	11
MLK3	89	1
MNK1	97	9
MNK2	106	4
MPSK1	107	3
MSK1	108	1
MST2	90	16
MST4	100	1
NEK2a	99	1
NEK6	107	14
NUAK1	75	0
p38 alpha MAPK	100	10
p38 beta MAPK	99	10
p38 delta MAPK	116	4
p38 gamma MAPK	93	5
PAK2	92	1
PAK4	93	2
PAK5	100	10
PAK6	83	8
PDK1	111	14
PHK	108	13
PIM1	96	4
PIM2	98	1
PIM3	111	9
PKA	100	1
PKB alpha	115	7
PKB beta	100	2
PKC alpha	93	0
PKC gamma	98	7
PKC zeta	104	0
PKD1	86	11
PLK1	98	9
PRAK	96	4
PRK2	106	0
RIPK2	86	16
ROCK 2	95	4
RSK1	101	9
RSK2	107	16
S6K1	100	3
SGK1	109	5
SmMLCK	96	5
Src	102	0
SRPK1	97	7
STK33	87	4
SYK	102	7
TAK1	92	17
TAO1	87	0
TBK1	99	15
TIE2	100	22
TrkA	90	2
TTK	100	17
VEGFR1	45	3
YES1	92	7
ZAP70	94	8

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	82	11
AMPK	86	12
ASK1	96	4
Aurora A	22	3
Aurora B	62	16
BRK	95	7
BRSK1	90	1
BRSK2	73	8
BTK	68	1
CAMK1	70	5
CAMKK beta	48	4
CDK2-Cyclin A	48	1
CHK1	84	1
CHK2	35	4
CK1 delta	81	10
CK2	106	11
CLK2	49	13
CSK	88	5
DAPK1	86	12
DYRK1A	48	2
DYRK2	86	2
DYRK3	109	11
EF2K	90	12
EPH-A2	52	6
EPH-A4	53	6
EPH-B1	76	39
EPH-B2	62	7
EPH-B3	109	6
EPH-B4	55	3
ERK1	125	16
ERK2	89	14
ERK8	67	5
FGF-R1	46	14
GCK	17	2
GSK3 beta	42	2
HER4	98	2
HIPK1	87	7
HIPK2	52	2
HIPK3	102	10
IGF-1R	79	1
IKK beta	93	5
IKK epsilon	109	11
IR	97	0
IRAK4	28	2
IRR	52	4
JAK2	60	5
JNK1	102	10
JNK2	96	2
JNK3	84	1
Lck	77	6
LKB1	81	11
MAPKAP-K2	91	22
MAPKAP-K3	93	6
MARK1	67	4
MARK2	124	73
MARK3	69	5
MARK4	69	12
MEKK1	132	51
MELK	44	5
MINK1	37	7
MKK1	88	5
MKK2	74	10
MKK6	99	1
MLK1	32	9
MLK3	37	1
MNK1	77	3
MNK2	115	13
MPSK1	92	3
MSK1	108	11
MST2	53	3
MST4	57	3
NEK2a	92	2
NEK6	93	3
NUAK1	30	2
p38 alpha MAPK	101	16
p38 beta MAPK	98	1
p38 delta MAPK	97	9
p38 gamma MAPK	94	12
PAK2	96	14
PAK4	46	4
PAK5	54	10
PAK6	80	14
PDK1	102	11
PHK	62	1
PIM1	87	2
PIM2	92	0
PIM3	68	9
PKA	102	15
PKB alpha	102	10
PKB beta	96	0
PKC alpha	86	9
PKC gamma	110	5
PKC zeta	104	11
PKD1	90	9
PLK1	100	4
PRAK	62	9
PRK2	97	13
RIPK2	36	1
ROCK 2	91	3
RSK1	95	1
RSK2	89	1
S6K1	98	6
SGK1	107	5
SmMLCK	49	4
Src	87	2
SRPK1	93	6
STK33	74	10
SYK	106	9
TAK1	53	8
TAO1	69	11
TBK1	107	2
TIE2	75	18
TrkA	30	3
TTK	80	13
VEGFR1	9	0
YES1	79	13
ZAP70	80	8