Inhibitor | IMD-0354  

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	111	13
Aurora A	107	14
Aurora B	118	15
BRSK1	120	17
BRSK2	105	3
BTK	123	2
CAMK1	105	11
CAMKK beta	109	4
CDK2-Cyclin A	118	4
CHK1	120	10
CHK2	108	6
CK1 delta	99	1
CK2	113	4
CSK	116	17
DYRK1A	84	3
DYRK2	104	1
DYRK3	75	10
EF2K	119	4
EPH-A2	113	3
EPH-A4	120	4
EPH-B3	121	0
EPH-B4	119	14
ERK1	117	18
ERK2	109	8
ERK8	107	9
FGF-R1	118	10
GCK	108	6
GSK3 beta	121	0
HER4	110	8
HIPK1	128	2
HIPK2	136	14
HIPK3	101	6
IGF-1R	94	15
IKK beta	90	16
IKK epsilon	99	5
IR	89	5
IRAK4	109	0
IRR	106	3
JAK2	98	3
JNK1	107	3
JNK2	112	3
JNK3	111	6
Lck	114	8
LKB1	113	0
MAPKAP-K2	97	6
MAPKAP-K3	91	23
MARK1	105	11
MARK2	94	3
MARK3	97	1
MARK4	105	11
MEKK1	105	1
MELK	104	3
MINK1	134	12
MKK1	111	14
MLK1	112	5
MLK3	115	1
MNK1	116	6
MNK2	95	11
MSK1	150	12
MST2	98	4
MST4	108	4
NEK2a	113	15
NEK6	141	8
NUAK1	100	5
p38 alpha MAPK	112	4
p38 beta MAPK	104	25
p38 delta MAPK	112	1
p38 gamma MAPK	140	19
PAK2	80	5
PAK4	96	2
PAK5	104	6
PAK6	119	7
PDK1	97	11
PHK	113	10
PIM1	109	12
PIM2	131	7
PIM3	105	7
PKA	99	5
PKB alpha	130	21
PKB beta	93	3
PKC alpha	95	14
PKC zeta	114	3
PKD1	109	15
PLK1	116	0
PRAK	65	4
PRK2	116	2
RIPK2	110	7
ROCK 2	111	1
RSK1	156	9
RSK2	116	4
S6K1	171	4
SGK1	170	1
SmMLCK	104	3
Src	101	14
SRPK1	72	0
SYK	109	25
TAK1	117	1
TBK1	100	7
TrkA	130	33
TTK	97	5
VEGFR1	107	17
YES1	92	5

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	84	2
Aurora A	74	1
Aurora B	123	9
BRSK1	89	4
BRSK2	95	8
BTK	88	2
CAMK1	111	9
CAMKK beta	101	0
CDK2-Cyclin A	97	0
CHK1	161	15
CHK2	112	1
CK1 delta	104	16
CK2	97	19
CSK	76	4
DYRK1A	51	3
DYRK2	85	9
DYRK3	55	12
EF2K	110	7
EPH-A2	89	0
EPH-A4	94	9
EPH-B3	117	3
EPH-B4	130	5
ERK1	111	6
ERK2	106	6
ERK8	54	26
FGF-R1	108	7
GCK	99	1
GSK3 beta	104	11
HER4	94	16
HIPK1	106	5
HIPK2	109	12
HIPK3	100	10
IGF-1R	94	0
IKK beta	87	17
IKK epsilon	67	10
IR	94	8
IRAK4	109	0
IRR	110	6
JAK2	81	7
JNK1	92	0
JNK2	87	3
JNK3	88	5
Lck	101	6
LKB1	95	0
MAPKAP-K2	72	5
MAPKAP-K3	71	3
MARK1	82	2
MARK2	80	3
MARK3	72	6
MARK4	87	1
MEKK1	102	8
MELK	66	14
MINK1	130	10
MKK1	70	9
MLK1	89	2
MLK3	98	5
MNK1	90	14
MNK2	94	5
MSK1	107	17
MST2	106	4
MST4	82	5
NEK2a	166	4
NEK6	105	9
NUAK1	60	9
p38 alpha MAPK	99	6
p38 beta MAPK	87	10
p38 delta MAPK	107	16
p38 gamma MAPK	127	8
PAK2	65	1
PAK4	89	1
PAK5	84	2
PAK6	126	5
PDK1	80	1
PHK	84	8
PIM1	60	21
PIM2	123	27
PIM3	63	7
PKA	56	9
PKB alpha	125	76
PKB beta	55	5
PKC alpha	95	11
PKC zeta	97	2
PKD1	98	6
PLK1	92	11
PRAK	49	10
PRK2	105	5
RIPK2	106	11
ROCK 2	90	6
RSK1	119	4
RSK2	61	3
S6K1	125	16
SGK1	256	1
SmMLCK	64	4
Src	60	14
SRPK1	47	1
SYK	73	2
TAK1	61	4
TBK1	69	15
TrkA	81	2
TTK	75	13
VEGFR1	71	13
YES1	73	10