Inhibitor | Hypothemycin  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Hypothemycin   C19H22O8 378.37 76958-67-3 6474405 cyclin D1 H. Sonoda (1999) Life Sci. 65 381 A. Zhao (1999) J. Antibiot. 52 1086

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
ABL 96 6
AMPK 105 2
ASK1 105 12
Aurora A 106 5
Aurora B 90 5
BRK 101 12
BRSK1 90 17
BRSK2 114 11
BTK 105 9
CAMK1 96 0
CAMKK beta 102 10
CDK2-Cyclin A 91 6
CDK9-Cyclin T1 97 5
CHK1 93 15
CHK2 91 3
CK1 delta 116 5
CK1 gamma 2 100 10
CK2 123 1
CLK2 94 2
CSK 97 25
DAPK1 82 18
DDR2 91 11
DYRK1A 98 1
DYRK2 109 4
DYRK3 113 6
EF2K 91 6
EIF2AK3 105 6
EPH-A2 97 3
EPH-A4 109 10
EPH-B1 97 5
EPH-B2 124 15
EPH-B3 118 19
EPH-B4 109 1
ERK1 111 5
ERK2 96 9
ERK8 80 14
FGF-R1 118 7
GCK 114 7
GSK3 beta 91 5
HER4 132 24
HIPK1 111 9
HIPK2 96 12
HIPK3 104 1
IGF-1R 103 14
IKK beta 103 3
IKK epsilon 108 9
IR 112 18
IRAK1 97 4
IRAK4 112 3
IRR 104 2
JAK2 84 2
JNK1 104 14
JNK2 105 14
JNK3 89 11
Lck 79 6
LKB1 119 10
MAPKAP-K2 93 7
MAPKAP-K3 105 19
MARK1 101 5
MARK2 90 7
MARK3 98 5
MARK4 103 1
MEKK1 112 1
MELK 92 2
MINK1 106 7
MKK1 101 3
MKK2 74 0
MKK6 59 0
MLK1 112 12
MLK3 91 20
MNK1 100 6
MNK2 91 2
MPSK1 94 5
MSK1 108 11
MST2 97 6
MST3 106 10
MST4 96 9
NEK2a 103 11
NEK6 97 19
NUAK1 93 5
OSR1 104 3
p38 alpha MAPK 108 18
p38 beta MAPK 88 6
p38 delta MAPK 101 6
p38 gamma MAPK 100 1
PAK2 99 1
PAK4 81 9
PAK5 102 0
PAK6 92 1
PDK1 89 5
PHK 100 7
PIM1 90 6
PIM2 93 3
PIM3 92 7
PKA 91 10
PKB alpha 109 2
PKB beta 105 2
PKC alpha 88 15
PKC gamma 103 17
PKC zeta 97 11
PKD1 89 13
PLK1 102 0
PRAK 74 11
PRK2 93 8
RIPK2 104 10
ROCK 2 91 5
RSK1 97 22
RSK2 129 16
S6K1 87 11
SGK1 93 2
SIK2 106 9
SIK3 102 4
SmMLCK 108 7
Src 96 15
SRPK1 111 19
STK33 113 9
SYK 112 26
TAK1 101 5
TAO1 106 3
TBK1 110 7
TESK1 120 36
TIE2 122 14
TLK1 95 5
TrkA 97 0
TSSK1 112 9
TTBK1 89 4
TTK 101 4
ULK1 91 2
ULK2 94 3
VEGFR1 65 15
WNK1 94 2
YES1 87 0
ZAP70 99 20
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 97 4
AMPK 105 14
ASK1 103 3
Aurora A 103 6
Aurora B 92 4
BRK 100 24
BRSK1 90 9
BRSK2 93 12
BTK 115 11
CAMK1 96 13
CAMKK beta 99 9
CDK2-Cyclin A 81 9
CDK9-Cyclin T1 117 17
CHK1 93 14
CHK2 91 12
CK1 delta 101 3
CK1 gamma 2 100 2
CK2 121 5
CLK2 100 3
CSK 105 9
DAPK1 108 10
DDR2 113 10
DYRK1A 105 4
DYRK2 105 6
DYRK3 109 3
EF2K 103 4
EIF2AK3 92 5
EPH-A2 98 5
EPH-A4 122 2
EPH-B1 110 3
EPH-B2 118 2
EPH-B3 130 12
EPH-B4 116 14
ERK1 102 9
ERK2 87 17
ERK8 27 0
FGF-R1 154 18
GCK 105 3
GSK3 beta 106 5
HER4 104 14
HIPK1 99 19
HIPK2 86 5
HIPK3 100 0
IGF-1R 100 14
IKK beta 100 3
IKK epsilon 105 4
IR 116 1
IRAK1 97 7
IRAK4 99 5
IRR 108 3
JAK2 101 6
JNK1 98 8
JNK2 106 6
JNK3 101 18
Lck 93 1
LKB1 120 19
MAPKAP-K2 101 4
MAPKAP-K3 99 2
MARK1 99 2
MARK2 100 1
MARK3 102 3
MARK4 99 3
MEKK1 101 13
MELK 100 2
MINK1 111 8
MKK1 21 5
MKK2 21 1
MKK6 21 12
MLK1 117 4
MLK3 102 0
MNK1 87 5
MNK2 62 16
MPSK1 86 30
MSK1 104 10
MST2 89 9
MST3 104 3
MST4 106 9
NEK2a 127 7
NEK6 90 12
NUAK1 99 3
OSR1 99 4
p38 alpha MAPK 105 6
p38 beta MAPK 93 1
p38 delta MAPK 100 3
p38 gamma MAPK 105 18
PAK2 94 6
PAK4 100 5
PAK5 115 2
PAK6 95 4
PDK1 88 22
PHK 98 2
PIM1 87 10
PIM2 114 2
PIM3 98 6
PKA 99 3
PKB alpha 124 2
PKB beta 103 7
PKC alpha 88 3
PKC gamma 109 4
PKC zeta 78 12
PKD1 41 1
PLK1 107 7
PRAK 72 17
PRK2 101 23
RIPK2 102 8
ROCK 2 94 15
RSK1 92 10
RSK2 125 19
S6K1 92 9
SGK1 91 15
SIK2 107 2
SIK3 93 7
SmMLCK 102 4
Src 91 5
SRPK1 95 11
STK33 105 1
SYK 108 2
TAK1 48 5
TAO1 101 2
TBK1 112 6
TESK1 107 6
TIE2 101 11
TLK1 101 7
TrkA 90 19
TSSK1 110 8
TTBK1 82 15
TTK 95 13
ULK1 88 1
ULK2 96 2
VEGFR1
5
 2
WNK1 107 1
YES1 85 18
ZAP70 101 7
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 105 5
AMPK 94 3
ASK1 109 4
Aurora A 108 5
Aurora B 107 1
BRK 48 2
BRSK1 82 9
BRSK2 96 3
BTK 109 2
CAMK1 112 6
CAMKK beta 94 29
CDK2-Cyclin A 76 2
CDK9-Cyclin T1 111 3
CHK1 94 12
CHK2 106 20
CK1 delta 92 22
CK1 gamma 2 109 6
CK2 133 7
CLK2 114 24
CSK 95 24
DAPK1 96 14
DDR2 133 55
DYRK1A 101 11
DYRK2 102 24
DYRK3 124 6
EF2K 133 26
EIF2AK3 121 48
EPH-A2 56 3
EPH-A4 107 3
EPH-B1 84 9
EPH-B2 115 0
EPH-B3 92 6
EPH-B4 116 35
ERK1 57 3
ERK2 36 3
ERK8 11 0
FGF-R1 132 24
GCK 97 7
GSK3 beta 113 48
HER4 105 3
HIPK1 95 12
HIPK2 72 12
HIPK3 102 4
IGF-1R 119 44
IKK beta 112 10
IKK epsilon 92 9
IR 97 4
IRAK1 109 43
IRAK4 57 2
IRR 113 11
JAK2 109 25
JNK1 80 3
JNK2 99 3
JNK3 107 5
Lck 69 8
LKB1 104 2
MAPKAP-K2 109 22
MAPKAP-K3 99 9
MARK1 101 9
MARK2 100 4
MARK3 95 13
MARK4 94 23
MEKK1 102 13
MELK 104 7
MINK1 102 16
MKK1
1
 1
MKK2
9
 0
MKK6 20 15
MLK1 101 7
MLK3 90 9
MNK1 55 3
MNK2 44 6
MPSK1 102 4
MSK1 104 8
MST2 102 3
MST3 114 13
MST4 86 1
NEK2a 105 4
NEK6 98 7
NUAK1 105 16
OSR1 129 30
p38 alpha MAPK 105 13
p38 beta MAPK 98 3
p38 delta MAPK 108 0
p38 gamma MAPK 114 28
PAK2 95 13
PAK4 104 31
PAK5 103 20
PAK6 95 13
PDK1 93 9
PHK 107 7
PIM1 92 5
PIM2 117 29
PIM3 99 6
PKA 100 18
PKB alpha 107 3
PKB beta 99 21
PKC alpha 92 13
PKC gamma 89 0
PKC zeta 105 5
PKD1 11 1
PLK1 114 2
PRAK 32 3
PRK2 89 27
RIPK2 85 6
ROCK 2 99 13
RSK1 85 4
RSK2 129 19
S6K1 106 5
SGK1 104 17
SIK2 88 10
SIK3 94 7
SmMLCK 96 2
Src 86 3
SRPK1 100 4
STK33 113 5
SYK 85 2
TAK1
2
 1
TAO1 100 5
TBK1 93 5
TESK1 92 12
TIE2 122 11
TLK1 120 31
TrkA 67 9
TSSK1 99 7
TTBK1 112 35
TTK 101 5
ULK1 92 15
ULK2 118 35
VEGFR1
3
 0
WNK1 106 3
YES1 81 21
ZAP70 103 10