Inhibitor | IKK-2 Inhibitor IV (TPCA-1)  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
IKK-2 Inhibitor IV (TPCA-1)   C12H10FN3O2S 279.30 507475-17-4 9903786 IKK2 Podolin P.L. (2005) J. Pharmacol. Exp. Ther. 312 373 Karin M. (2004) Nat. Rev. Drug Discov. 3 17

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 83 7
ASK1 62 1
Aurora A 54 8
Aurora B 21 2
BRSK1 77 10
BRSK2 98 6
BTK 26 1
CAMK1 82 2
CAMKK beta 66 2
CDK2-Cyclin A 35 5
CHK1 83 1
CHK2 51 8
CK1 delta 97 1
CK2 109 8
CLK2 84 5
CSK 101 12
DAPK1 62 3
DYRK1A 97 1
DYRK2 100 8
DYRK3 101 4
EF2K 103 6
EPH-A2 59 11
EPH-A4 73 10
EPH-B1 68 6
EPH-B2 83 10
EPH-B3 37 2
EPH-B4 85 8
ERK1 107 10
ERK2 102 11
ERK8 83 2
FGF-R1 61 3
GCK 48 1
GSK3 beta 87 1
HER4 70 11
HIPK1 109 0
HIPK2 101 5
HIPK3 100 12
IGF-1R 64 14
IKK beta 15 0
IKK epsilon 86 3
IR 94 14
IRAK4 61 0
IRR 96 7
JAK2 11 1
JNK1 93 8
JNK2 106 4
JNK3 93 2
Lck 80 2
LKB1 71 0
MAPKAP-K2 98 9
MAPKAP-K3 94 10
MARK1 98 10
MARK2 76 10
MARK3 81 2
MARK4 91 7
MEKK1 61 6
MELK 89 2
MINK1 69 12
MKK1 74 1
MKK2 54 0
MKK6 89 8
MLK1 21 0
MLK3 19 0
MNK1 100 3
MNK2 105 5
MSK1 97 0
MST2 50 7
MST4 79 0
NEK2a 94 8
NEK6 108 3
NUAK1 31 1
p38 alpha MAPK 101 9
p38 beta MAPK 96 4
p38 delta MAPK 122 11
p38 gamma MAPK 92 4
PAK2 97 13
PAK4 74 2
PAK5 88 8
PAK6 90 0
PDK1 87 0
PHK 90 3
PIM1 85 4
PIM2 104 8
PIM3 78 6
PKA 98 3
PKB alpha 97 7
PKB beta 90 15
PKC alpha 81 1
PKC zeta 102 3
PKD1 86 5
PLK1 91 0
PRAK 100 7
PRK2 71 4
RIPK2 90 4
ROCK 2 80 3
RSK1 77 3
RSK2 76 5
S6K1 102 1
SGK1 108 6
SmMLCK 104 7
Src 39 2
SRPK1 92 8
SYK 91 3
TAK1 21 0
TAO1 71 4
TBK1 75 0
TrkA 32 1
TTK 94 3
VEGFR1 23 0
YES1 57 11
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 26 1
ASK1 14 1
Aurora A 11 1
Aurora B
5
 1
BRSK1 27 2
BRSK2 42 4
BTK
10
 0
CAMK1 35 9
CAMKK beta 77 2
CDK2-Cyclin A
8
 2
CHK1 39 2
CHK2 17 10
CK1 delta 81 7
CK2 67 0
CLK2 35 1
CSK 90 9
DAPK1 21 0
DYRK1A 65 5
DYRK2 50 3
DYRK3 73 2
EF2K 54 8
EPH-A2 31 0
EPH-A4 21 1
EPH-B1 17 1
EPH-B2 18 1
EPH-B3 12 5
EPH-B4 34 1
ERK1 62 5
ERK2 68 9
ERK8 25 1
FGF-R1 17 1
GCK
8
 0
GSK3 beta 47 2
HER4 22 2
HIPK1 87 7
HIPK2 49 15
HIPK3 81 6
IGF-1R
9
 2
IKK beta
8
 0
IKK epsilon 30 1
IR 46 5
IRAK4 13 1
IRR 57 6
JAK2
9
 3
JNK1 83 4
JNK2 83 1
JNK3 65 1
Lck 36 3
LKB1 32 0
MAPKAP-K2 85 1
MAPKAP-K3 74 1
MARK1 44 3
MARK2 52 12
MARK3 45 1
MARK4 57 6
MEKK1 17 4
MELK 45 1
MINK1 13 1
MKK1 23 2
MKK2 13 1
MKK6 62 7
MLK1
4
 1
MLK3
2
 0
MNK1 56 11
MNK2 58 3
MSK1 80 4
MST2 12 0
MST4 19 2
NEK2a 65 2
NEK6 98 8
NUAK1
8
 1
p38 alpha MAPK 81 3
p38 beta MAPK 65 8
p38 delta MAPK 85 7
p38 gamma MAPK 59 13
PAK2 72 5
PAK4 33 2
PAK5 40 8
PAK6 49 4
PDK1 34 3
PHK 31 2
PIM1 40 5
PIM2 37 1
PIM3 38 2
PKA 85 6
PKB alpha 85 4
PKB beta 60 10
PKC alpha 44 3
PKC zeta 94 12
PKD1 46 0
PLK1 77 2
PRAK 77 1
PRK2 41 7
RIPK2 29 1
ROCK 2 56 4
RSK1 23 4
RSK2 36 1
S6K1 81 4
SGK1 91 2
SmMLCK 42 3
Src 14 3
SRPK1 76 4
SYK 38 2
TAK1
5
 2
TAO1 21 2
TBK1 38 8
TrkA 26 3
TTK 64 4
VEGFR1
4
 0
YES1 15 1