Inhibitor | HG-9-91-01  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
HG-9-91-01   C32H38ClN7O3 604.14 SIK Clark K. (2012) Proc Natl Acad Sci USA 109(42) 16986-91

Screening Results Chart

Screening Results Tables

Screen Conc: 0.01µM
Kinase % Activity Remaining Standard Deviation
ABL 87 6
AMPK 97 3
ASK1 110 16
Aurora A 98 10
Aurora B 93 5
BRK 97 12
BRSK1 103 13
BRSK2 99 24
BTK 91 0
CAMK1 97 11
CAMKK beta 105 16
CDK2-Cyclin A 120 12
CDK9-Cyclin T1 104 8
CHK1 95 3
CHK2 89 12
CK1 delta 89 2
CK1 gamma 2 96 3
CK2 98 9
CLK2 97 14
CSK 119 2
DAPK1 98 21
DDR2 17 1
DYRK1A 100 3
DYRK2 89 6
DYRK3 92 10
EF2K 95 30
EIF2AK3 91 4
EPH-A2 51 4
EPH-A4 71 12
EPH-B1 62 4
EPH-B2 109 10
EPH-B3 108 5
EPH-B4 110 4
ERK1 104 3
ERK2 103 11
ERK8 108 16
FGF-R1 102 9
GCK 103 3
GSK3 beta 107 29
HER4 90 8
HIPK1 69 6
HIPK2 119 29
HIPK3 80 3
IGF-1R 120 38
IKK beta 83 14
IKK epsilon 112 25
IR 115 10
IRAK1 98 7
IRAK4 90 7
IRR 113 6
JAK2 99 2
JNK1 94 8
JNK2 103 2
JNK3 93 7
Lck 63 16
LKB1 108 10
MAPKAP-K2 101 2
MAPKAP-K3 96 8
MARK1 88 8
MARK2 101 9
MARK3 92 0
MARK4 120 6
MEKK1 94 15
MELK 105 4
MINK1 94 3
MKK1 107 1
MKK2 101 6
MKK6 110 22
MLK1 101 5
MLK3 105 6
MNK1 109 4
MNK2 107 10
MPSK1 106 2
MSK1 104 2
MST2 112 6
MST3 105 2
MST4 100 3
NEK2a 112 4
NEK6 102 6
NUAK1 97 0
OSR1 101 1
p38 alpha MAPK 121 8
p38 beta MAPK 89 6
p38 delta MAPK 102 0
p38 gamma MAPK 110 1
PAK2 87 19
PAK4 116 2
PAK5 95 7
PAK6 94 2
PDK1 112 10
PHK 125 2
PIM1 107 6
PIM2 109 36
PIM3 103 15
PKA 91 17
PKB alpha 98 9
PKB beta 83 11
PKC alpha 102 14
PKC gamma 101 4
PKC zeta 97 12
PKD1 96 17
PLK1 98 16
PRAK 119 6
PRK2 106 25
RIPK2 77 6
ROCK 2 90 4
RSK1 106 10
RSK2 100 1
S6K1 88 10
SGK1 94 7
SIK2 62 1
SIK3 83 0
SmMLCK 99 13
Src 45 4
SRPK1 96 3
STK33 113 6
SYK 112 10
TAK1 121 21
TAO1 85 6
TBK1 101 1
TESK1 82 5
TIE2 116 8
TLK1 98 4
TrkA 98 16
TSSK1 108 0
TTBK1 100 13
TTK 100 3
VEGFR1 95 1
WNK1 100 13
YES1 34 2
ZAP70 96 1
Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 39 5
AMPK 97 4
ASK1 119 11
Aurora A 91 15
Aurora B 92 2
BRK 24 2
BRSK1 99 4
BRSK2 97 2
BTK 38 4
CAMK1 90 5
CAMKK beta 102 2
CDK2-Cyclin A 121 5
CDK9-Cyclin T1 87 11
CHK1 100 18
CHK2 75 4
CK1 delta 85 7
CK1 gamma 2 93 2
CK2 100 4
CLK2 100 2
CSK 101 5
DAPK1 88 19
DDR2
8
 0
DYRK1A 95 9
DYRK2 85 18
DYRK3 92 7
EF2K 108 11
EIF2AK3 97 2
EPH-A2 15 0
EPH-A4 12 3
EPH-B1 49 8
EPH-B2 43 15
EPH-B3 61 9
EPH-B4 80 4
ERK1 101 17
ERK2 110 13
ERK8 112 4
FGF-R1 34 2
GCK 72 12
GSK3 beta 103 21
HER4 66 21
HIPK1 60 12
HIPK2 115 24
HIPK3 86 10
IGF-1R 119 25
IKK beta 95 12
IKK epsilon 94 2
IR 106 3
IRAK1 95 3
IRAK4 97 5
IRR 112 11
JAK2 88 9
JNK1 107 3
JNK2 90 4
JNK3 77 2
Lck 54 4
LKB1 106 0
MAPKAP-K2 100 3
MAPKAP-K3 90 4
MARK1 87 8
MARK2 90 5
MARK3 73 2
MARK4 101 7
MEKK1 97 29
MELK 93 19
MINK1 76 2
MKK1 106 4
MKK2 96 0
MKK6 101 9
MLK1 97 2
MLK3 100 8
MNK1 116 13
MNK2 107 6
MPSK1 106 9
MSK1 105 3
MST2 109 13
MST3 81 33
MST4 95 16
NEK2a 93 5
NEK6 90 8
NUAK1 93 0
OSR1 93 4
p38 alpha MAPK 79 7
p38 beta MAPK 42 2
p38 delta MAPK 97 0
p38 gamma MAPK 112 2
PAK2 59 17
PAK4 97 13
PAK5 91 8
PAK6 101 8
PDK1 96 8
PHK 104 2
PIM1 113 14
PIM2 79 23
PIM3 110 0
PKA 96 10
PKB alpha 92 8
PKB beta 83 5
PKC alpha 102 7
PKC gamma 104 2
PKC zeta 104 5
PKD1 36 0
PLK1 102 6
PRAK 115 2
PRK2 99 8
RIPK2 37 3
ROCK 2 103 25
RSK1 91 13
RSK2 92 1
S6K1 99 6
SGK1 103 26
SIK2 13 3
SIK3 36 7
SmMLCK 89 9
Src
9
 2
SRPK1 85 13
STK33 106 4
SYK 104 4
TAK1 110 5
TAO1 69 0
TBK1 91 8
TESK1 29 3
TIE2 82 14
TLK1 93 8
TrkA 100 23
TSSK1 102 12
TTBK1 117 5
TTK 92 2
VEGFR1 64 2
WNK1 107 2
YES1 11 1
ZAP70 98 0
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL
7
 3
AMPK 96 6
ASK1 128 39
Aurora A 70 1
Aurora B 91 6
BRK
3
 0
BRSK1 86 4
BRSK2 88 4
BTK 21 7
CAMK1 90 10
CAMKK beta 89 7
CDK2-Cyclin A 106 3
CDK9-Cyclin T1 95 6
CHK1 86 3
CHK2 34 0
CK1 delta 79 13
CK1 gamma 2 99 20
CK2 100 6
CLK2 108 5
CSK 38 0
DAPK1 96 15
DDR2
6
 1
DYRK1A 93 8
DYRK2 93 3
DYRK3 97 0
EF2K 89 5
EIF2AK3 95 7
EPH-A2
6
 0
EPH-A4
6
 2
EPH-B1
2
 0
EPH-B2
1
 0
EPH-B3 18 1
EPH-B4
5
 1
ERK1 95 0
ERK2 109 15
ERK8 94 14
FGF-R1
2
 0
GCK 21 4
GSK3 beta 88 6
HER4 18 3
HIPK1 56 5
HIPK2 114 24
HIPK3 74 8
IGF-1R 115 36
IKK beta 99 16
IKK epsilon 102 13
IR 106 3
IRAK1 95 10
IRAK4 90 1
IRR 107 5
JAK2 89 8
JNK1 86 12
JNK2 21 2
JNK3 38 7
Lck 47 0
LKB1 96 19
MAPKAP-K2 97 3
MAPKAP-K3 75 8
MARK1 53 4
MARK2 63 12
MARK3 28 5
MARK4 67 18
MEKK1 99 22
MELK 71 4
MINK1 18 1
MKK1 97 19
MKK2 85 4
MKK6 92 6
MLK1 42 6
MLK3 70 12
MNK1 112 15
MNK2 102 1
MPSK1 106 15
MSK1 110 21
MST2 118 5
MST3 40 13
MST4 78 8
NEK2a 95 6
NEK6 91 17
NUAK1 64 4
OSR1 57 4
p38 alpha MAPK 26 1
p38 beta MAPK 19 5
p38 delta MAPK 98 1
p38 gamma MAPK 105 2
PAK2 18 10
PAK4 94 12
PAK5 72 16
PAK6 88 8
PDK1 103 12
PHK 107 11
PIM1 111 8
PIM2 117 1
PIM3 103 7
PKA 79 11
PKB alpha 91 10
PKB beta 75 16
PKC alpha 104 6
PKC gamma 96 6
PKC zeta 102 2
PKD1 15 1
PLK1 97 9
PRAK 125 3
PRK2 90 10
RIPK2
8
 3
ROCK 2 68 5
RSK1 38 5
RSK2 54 10
S6K1 93 6
SGK1 93 8
SIK2
6
 5
SIK3
5
 1
SmMLCK 91 4
Src
3
 1
SRPK1 90 11
STK33 107 9
SYK 100 19
TAK1 84 6
TAO1 33 6
TBK1 91 9
TESK1 16 5
TIE2 42 12
TLK1 93 3
TrkA 89 3
TSSK1 62 4
TTBK1 112 12
TTK 75 1
VEGFR1 15 2
WNK1 102 4
YES1
8
 3
ZAP70 94 9