Inhibitor | SYK Inhibitor IV (BAY 61-3606)  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	100	4
Aurora B	79	4
BRSK2	121	10
BTK	85	3
CAMK1	111	3
CAMKK beta	71	1
CDK2-Cyclin A	54	4
CHK1	114	3
CHK2	93	24
CK1 delta	93	0
CK2	102	1
CSK	94	2
DYRK1A	85	9
DYRK2	95	13
DYRK3	86	10
EF2K	132	2
EPH-A2	106	1
EPH-B3	111	5
ERK1	93	7
ERK2	87	2
ERK8	71	8
FGF-R1	90	0
GSK3 beta	78	8
HIPK2	77	0
IGF-1R	72	5
IKK beta	77	1
IKK epsilon	91	6
IR	41	1
IRR	76	10
JNK1	100	2
JNK2	107	7
Lck	110	3
MAPKAP-K2	101	0
MARK3	76	5
MELK	80	3
MKK1	95	11
MNK1	88	9
MNK2	92	1
MSK1	101	13
MST2	94	8
MST4	112	1
NEK2a	87	0
NEK6	97	5
p38 alpha MAPK	101	13
p38 beta MAPK	108	8
p38 delta MAPK	101	18
p38 gamma MAPK	106	3
PAK4	74	6
PAK5	84	1
PAK6	109	1
PDK1	119	16
PHK	105	5
PIM1	103	16
PIM2	112	9
PIM3	93	23
PKA	112	6
PKB alpha	101	5
PKB beta	105	6
PKC alpha	79	8
PKC zeta	93	8
PKD1	37	2
PLK1	95	2
PRAK	107	3
PRK2	68	14
ROCK 2	49	6
RSK1	101	3
RSK2	125	5
S6K1	108	8
SGK1	104	6
SmMLCK	95	13
Src	82	5
SRPK1	101	5
SYK	67	8
TBK1	97	0
VEGFR1	83	0
YES1	86	13

Screen Conc: 0.20µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	85	2
ASK1	90	1
Aurora A	107	10
Aurora B	81	0
BRSK1	78	6
BRSK2	92	5
BTK	85	8
CAMK1	81	1
CAMKK beta	67	7
CDK2-Cyclin A	46	2
CHK1	76	6
CHK2	92	4
CK1 delta	86	3
CK2	84	6
CLK2	35	1
CSK	82	1
DAPK1	73	2
DYRK1A	80	1
DYRK2	72	7
DYRK3	50	3
EF2K	78	7
EPH-A2	74	4
EPH-A4	100	10
EPH-B1	87	1
EPH-B2	98	12
EPH-B3	82	6
EPH-B4	80	4
ERK1	71	3
ERK2	59	3
ERK8	66	6
FGF-R1	109	14
GCK	8	1
GSK3 beta	26	0
HER4	72	10
HIPK1	81	11
HIPK2	49	11
HIPK3	87	8
IGF-1R	62	3
IKK beta	62	5
IKK epsilon	52	1
IR	40	7
IRAK4	84	1
IRR	68	7
JAK2	78	4
JNK1	99	3
JNK2	81	5
JNK3	66	3
Lck	92	0
LKB1	87	6
MAPKAP-K2	89	3
MAPKAP-K3	75	12
MARK1	89	4
MARK2	95	12
MARK3	76	3
MARK4	90	1
MEKK1	89	9
MELK	63	1
MINK1	58	5
MKK1	76	2
MKK2	84	11
MKK6	84	1
MLK1	64	1
MLK3	63	5
MNK1	97	5
MNK2	78	13
MSK1	67	9
MST2	74	2
MST4	89	0
NEK2a	89	3
NEK6	102	0
NUAK1	65	12
p38 alpha MAPK	92	5
p38 beta MAPK	76	10
p38 delta MAPK	65	3
p38 gamma MAPK	87	4
PAK2	88	11
PAK4	88	6
PAK5	79	8
PAK6	86	2
PDK1	91	6
PHK	73	2
PIM1	78	5
PIM2	85	3
PIM3	76	5
PKA	92	4
PKB alpha	84	10
PKB beta	91	1
PKC alpha	57	3
PKC zeta	86	8
PKD1	42	1
PLK1	86	6
PRAK	83	3
PRK2	73	1
RIPK2	50	2
ROCK 2	42	6
RSK1	84	7
RSK2	80	2
S6K1	76	7
SGK1	88	2
SmMLCK	102	8
Src	84	7
SRPK1	83	8
SYK	54	8
TAK1	37	0
TAO1	79	4
TBK1	75	3
TrkA	78	9
TTK	64	3
VEGFR1	56	2
YES1	82	0

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	96	3
ASK1	95	2
Aurora A	99	9
Aurora B	59	1
BRSK1	88	3
BRSK2	110	0
BTK	87	12
CAMK1	90	11
CAMKK beta	56	1
CDK2-Cyclin A	29	1
CHK1	89	7
CHK2	67	10
CK1 delta	87	0
CK2	82	4
CLK2	22	4
CSK	79	7
DAPK1	77	9
DYRK1A	55	3
DYRK2	55	7
DYRK3	32	0
EF2K	85	10
EPH-A2	79	1
EPH-A4	94	2
EPH-B1	91	9
EPH-B2	92	4
EPH-B3	81	2
EPH-B4	83	4
ERK1	67	9
ERK2	73	6
ERK8	57	4
FGF-R1	71	5
GCK	5	0
GSK3 beta	17	1
HER4	70	7
HIPK1	75	3
HIPK2	34	5
HIPK3	85	4
IGF-1R	26	4
IKK beta	53	1
IKK epsilon	55	8
IR	20	4
IRAK4	74	8
IRR	63	2
JAK2	60	5
JNK1	96	2
JNK2	90	3
JNK3	74	0
Lck	105	6
LKB1	85	5
MAPKAP-K2	94	4
MAPKAP-K3	81	1
MARK1	73	7
MARK2	81	2
MARK3	72	6
MARK4	100	11
MEKK1	97	5
MELK	77	12
MINK1	65	4
MKK1	75	1
MKK2	91	10
MKK6	89	5
MLK1	54	3
MLK3	33	1
MNK1	83	6
MNK2	65	12
MSK1	82	5
MST2	50	3
MST4	93	7
NEK2a	103	8
NEK6	86	3
NUAK1	49	1
p38 alpha MAPK	99	3
p38 beta MAPK	85	6
p38 delta MAPK	89	12
p38 gamma MAPK	102	3
PAK2	89	3
PAK4	83	11
PAK5	79	4
PAK6	93	14
PDK1	83	6
PHK	78	9
PIM1	62	1
PIM2	87	2
PIM3	52	5
PKA	102	1
PKB alpha	83	2
PKB beta	89	3
PKC alpha	46	0
PKC zeta	98	13
PKD1	23	5
PLK1	90	1
PRAK	87	1
PRK2	53	3
RIPK2	32	3
ROCK 2	21	7
RSK1	81	2
RSK2	91	8
S6K1	81	1
SGK1	96	6
SmMLCK	76	2
Src	84	9
SRPK1	98	10
SYK	40	8
TAK1	24	0
TAO1	80	2
TBK1	87	2
TrkA	73	5
TTK	70	1
VEGFR1	52	1
YES1	69	7

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	93	0
Aurora B	35	1
BRSK2	71	30
BTK	61	10
CAMK1	98	5
CAMKK beta	32	3
CDK2-Cyclin A	21	1
CHK1	98	13
CHK2	70	17
CK1 delta	65	2
CK2	48	5
CSK	98	4
DYRK1A	55	0
DYRK2	58	2
DYRK3	51	3
EF2K	114	10
EPH-A2	94	3
EPH-B3	103	3
ERK1	71	4
ERK2	65	1
ERK8	27	2
FGF-R1	94	18
GSK3 beta	31	0
HIPK2	39	4
IGF-1R	16	2
IKK beta	252	262
IKK epsilon	54	1
IR	11	1
IRR	43	8
JNK1	97	9
JNK2	92	1
Lck	80	3
MAPKAP-K2	82	13
MARK3	57	4
MELK	56	3
MKK1	47	0
MNK1	57	0
MNK2	56	0
MSK1	108	7
MST2	49	1
MST4	189	157
NEK2a	131	6
NEK6	80	0
p38 alpha MAPK	109	10
p38 beta MAPK	85	8
p38 delta MAPK	88	6
p38 gamma MAPK	77	18
PAK4	67	5
PAK5	68	6
PAK6	86	3
PDK1	91	2
PHK	95	15
PIM1	71	2
PIM2	93	3
PIM3	40	4
PKA	99	13
PKB alpha	95	1
PKB beta	123	8
PKC alpha	45	17
PKC zeta	87	2
PKD1	9	1
PLK1	94	5
PRAK	72	0
PRK2	38	1
ROCK 2	18	5
RSK1	89	10
RSK2	93	2
S6K1	104	14
SGK1	88	6
SmMLCK	75	8
Src	54	2
SRPK1	102	2
SYK	27	3
TBK1	84	1
VEGFR1	70	0
YES1	80	4