Inhibitor | SYK Inhibitor I  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
SYK Inhibitor I   C18H15N3O3S 353.40 622387-85-3 6419747 SYK Lai J.Y. (2003) Bioorg. Med. Chem. Lett. 13 3111

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
AMPK 53 4
ASK1 68 0
Aurora A 54 12
Aurora B 75 2
BRSK1 78 3
BRSK2 84 4
BTK 48 0
CAMK1 95 3
CAMKK beta 47 1
CDK2-Cyclin A 64 7
CHK1 39 0
CHK2
8
 4
CK1 delta 93 7
CK2 85 11
CLK2 40 11
CSK 92 14
DAPK1 85 8
DYRK1A 96 2
DYRK2 89 2
DYRK3 89 10
EF2K 79 6
EPH-A2 100 1
EPH-A4 83 8
EPH-B1 101 1
EPH-B2 84 8
EPH-B3 95 11
EPH-B4 85 2
ERK1 87 0
ERK2 86 3
ERK8 63 2
FGF-R1 61 5
GCK 24 1
GSK3 beta 78 7
HER4 105 8
HIPK1 96 11
HIPK2 66 1
HIPK3 108 1
IGF-1R 89 14
IKK beta 83 3
IKK epsilon 41 1
IR 56 10
IRAK4
9
 1
IRR 87 2
JAK2 29 2
JNK1 95 7
JNK2 79 5
JNK3 72 10
Lck 71 5
LKB1 81 7
MAPKAP-K2 99 7
MAPKAP-K3 85 12
MARK1 83 7
MARK2 95 1
MARK3 83 6
MARK4 99 9
MEKK1 39 5
MELK 81 10
MINK1 54 11
MKK1 45 2
MKK2 88 1
MKK6 102 2
MLK1 45 0
MLK3 24 1
MNK1 85 12
MNK2 97 9
MSK1 77 4
MST2 26 0
MST4 93 2
NEK2a 88 5
NEK6 84 5
NUAK1 30 0
p38 alpha MAPK 94 7
p38 beta MAPK 85 11
p38 delta MAPK 107 3
p38 gamma MAPK 81 4
PAK2 93 7
PAK4 79 11
PAK5 70 3
PAK6 84 2
PDK1 83 6
PHK 32 2
PIM1 101 4
PIM2 79 1
PIM3 92 10
PKA 89 9
PKB alpha 82 8
PKB beta 107 14
PKC alpha 100 5
PKC zeta 110 1
PKD1 91 1
PLK1 82 0
PRAK 87 4
PRK2 78 4
RIPK2 68 2
ROCK 2 59 3
RSK1 34 2
RSK2 41 5
S6K1 64 1
SGK1 85 2
SmMLCK 86 11
Src 68 3
SRPK1 89 5
SYK 52 2
TAK1 48 2
TAO1 85 5
TBK1 56 7
TrkA 12 4
TTK 77 4
VEGFR1 56 10
YES1 42 3
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
AMPK 20 2
ASK1 16 2
Aurora A
5
 1
Aurora B 38 3
BRSK1 51 3
BRSK2 33 9
BTK 21 1
CAMK1 40 4
CAMKK beta 24 4
CDK2-Cyclin A 27 4
CHK1
8
 1
CHK2
4
 3
CK1 delta 81 2
CK2 89 11
CLK2
6
 3
CSK 63 15
DAPK1 83 1
DYRK1A 74 2
DYRK2 78 4
DYRK3 91 1
EF2K 70 2
EPH-A2 80 0
EPH-A4 41 3
EPH-B1 83 2
EPH-B2 37 2
EPH-B3 69 2
EPH-B4 45 1
ERK1 70 3
ERK2 78 1
ERK8 15 1
FGF-R1 14 0
GCK
8
 1
GSK3 beta 46 1
HER4 81 1
HIPK1 68 7
HIPK2 25 2
HIPK3 78 6
IGF-1R 84 13
IKK beta 68 11
IKK epsilon 20 1
IR 24 2
IRAK4
5
 1
IRR 78 3
JAK2
7
 0
JNK1 83 11
JNK2 72 0
JNK3 60 7
Lck 17 2
LKB1 62 9
MAPKAP-K2 109 8
MAPKAP-K3 80 9
MARK1 42 3
MARK2 63 2
MARK3 32 3
MARK4 49 7
MEKK1 21 1
MELK 56 7
MINK1 23 9
MKK1 14 1
MKK2 48 3
MKK6 93 4
MLK1 32 0
MLK3
7
 0
MNK1 68 4
MNK2 90 6
MSK1 55 3
MST2
7
 0
MST4 51 2
NEK2a 42 5
NEK6 100 11
NUAK1 22 3
p38 alpha MAPK 79 3
p38 beta MAPK 69 3
p38 delta MAPK 108 10
p38 gamma MAPK 77 0
PAK2 92 3
PAK4 37 0
PAK5 32 0
PAK6 69 0
PDK1 63 0
PHK
6
 0
PIM1 83 1
PIM2 84 5
PIM3 58 4
PKA 87 2
PKB alpha 75 1
PKB beta 74 12
PKC alpha 92 6
PKC zeta 93 4
PKD1 69 3
PLK1 87 11
PRAK 72 7
PRK2 45 3
RIPK2 24 6
ROCK 2 22 0
RSK1
6
 0
RSK2 11 0
S6K1 25 1
SGK1 67 2
SmMLCK 53 4
Src 24 9
SRPK1 42 0
SYK 18 4
TAK1 11 0
TAO1 53 1
TBK1 22 6
TrkA
10
 0
TTK 41 1
VEGFR1 24 10
YES1 21 3
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
AMPK
8
 0
Aurora B
2
 0
BRSK2
9
 2
BTK
5
 1
CAMK1 30 13
CAMKK beta
7
 0
CDK2-Cyclin A 44 1
CHK1
1
 5
CHK2
-7
 2
CK1 delta 96 4
CK2 67 7
CSK 61 2
DYRK1A 68 5
DYRK2 63 4
DYRK3 84 5
EF2K 115 4
EPH-A2 35 2
EPH-B3 56 0
ERK1 84 7
ERK2 72 3
ERK8
2
 2
FGF-R1
3
 0
GSK3 beta 56 13
HIPK2 19 0
IGF-1R 64 13
IKK beta 79 5
IKK epsilon
4
 2
IR 13 5
IRR 42 11
JNK1 91 0
JNK2 78 0
Lck 13 12
MAPKAP-K2 58 6
MARK3 18 3
MELK 19 4
MKK1
10
 2
MNK1 40 0
MNK2 68 5
MSK1 55 5
MST2
1
 0
MST4 11 3
NEK2a
6
 0
NEK6 93 14
p38 alpha MAPK 87 0
p38 beta MAPK 65 3
p38 delta MAPK 51 4
p38 gamma MAPK 66 5
PAK4
9
 4
PAK5 11 1
PAK6 15 3
PDK1 44 5
PHK
3
 1
PIM1 70 0
PIM2 108 7
PIM3 31 2
PKA 66 11
PKB alpha 67 17
PKB beta 95 0
PKC alpha 81 11
PKC zeta 85 0
PKD1 36 6
PLK1 80 14
PRAK 39 3
PRK2 11 2
ROCK 2
9
 2
RSK1
6
 0
RSK2
3
 0
S6K1 35 14
SGK1 28 3
SmMLCK 45 3
Src
2
 0
SRPK1 19 1
SYK 50 63
TBK1
3
 0
VEGFR1
7
 0
YES1
-5
 13