Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
---|---|---|---|---|---|---|---|
SYK Inhibitor II | C14H15F3N6O • 2HCl•2H2O | 449.30 | 227449-73-2 | 16760670 | SYK | Hisamichi H. (2005) Bioorg. Med. Chem. 13 4936 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 95 | 8 |
ASK1 | 91 | 4 |
Aurora A | 106 | 1 |
Aurora B | 106 | 8 |
BRSK1 | 97 | 5 |
BRSK2 | 96 | 13 |
BTK | 86 | 3 |
CAMK1 | 58 | 1 |
CAMKK beta | 92 | 3 |
CDK2-Cyclin A | 102 | 1 |
CHK1 | 93 | 6 |
CHK2 | 37 | 7 |
CK1 delta | 106 | 8 |
CK2 | 102 | 6 |
CLK2 | 91 | 4 |
CSK | 87 | 2 |
DAPK1 | 87 | 2 |
DYRK1A | 87 | 4 |
DYRK2 | 97 | 15 |
DYRK3 | 103 | 4 |
EF2K | 97 | 3 |
EPH-A2 | 93 | 0 |
EPH-A4 | 89 | 2 |
EPH-B1 | 114 | 1 |
EPH-B2 | 102 | 1 |
EPH-B3 | 103 | 9 |
EPH-B4 | 99 | 3 |
ERK1 | 106 | 9 |
ERK2 | 86 | 3 |
ERK8 | 95 | 13 |
FGF-R1 | 95 | 3 |
GCK | 62 | 2 |
GSK3 beta | 99 | 10 |
HER4 | 98 | 6 |
HIPK1 | 87 | 2 |
HIPK2 | 98 | 10 |
HIPK3 | 107 | 6 |
IGF-1R | 95 | 0 |
IKK beta | 105 | 8 |
IKK epsilon | 95 | 2 |
IR | 92 | 7 |
IRAK4 | 98 | 1 |
IRR | 101 | 3 |
JAK2 | 96 | 14 |
JNK1 | 101 | 0 |
JNK2 | 87 | 10 |
JNK3 | 98 | 11 |
Lck | 101 | 1 |
LKB1 | 76 | 1 |
MAPKAP-K2 | 99 | 15 |
MAPKAP-K3 | 94 | 4 |
MARK1 | 111 | 7 |
MARK2 | 94 | 9 |
MARK3 | 98 | 0 |
MARK4 | 97 | 11 |
MEKK1 | 109 | 4 |
MELK | 81 | 6 |
MINK1 | 94 | 10 |
MKK1 | 85 | 5 |
MKK2 | 96 | 4 |
MKK6 | 97 | 7 |
MLK1 | 79 | 4 |
MLK3 | 88 | 6 |
MNK1 | 111 | 5 |
MNK2 | 89 | 8 |
MSK1 | 94 | 10 |
MST2 | 77 | 1 |
MST4 | 91 | 5 |
NEK2a | 97 | 3 |
NEK6 | 108 | 11 |
NUAK1 | 92 | 13 |
p38 alpha MAPK | 104 | 1 |
p38 beta MAPK | 98 | 2 |
p38 delta MAPK | 102 | 6 |
p38 gamma MAPK | 102 | 6 |
PAK2 | 94 | 3 |
PAK4 | 90 | 13 |
PAK5 | 84 | 5 |
PAK6 | 94 | 8 |
PDK1 | 104 | 7 |
PHK | 89 | 6 |
PIM1 | 97 | 4 |
PIM2 | 94 | 8 |
PIM3 | 35 | 6 |
PKA | 95 | 5 |
PKB alpha | 109 | 3 |
PKB beta | 94 | 11 |
PKC alpha | 80 | 6 |
PKC zeta | 98 | 4 |
PKD1 | 74 | 2 |
PLK1 | 99 | 9 |
PRAK | 91 | 5 |
PRK2 | 105 | 6 |
RIPK2 | 98 | 2 |
ROCK 2 | 86 | 15 |
RSK1 | 92 | 6 |
RSK2 | 98 | 6 |
S6K1 | 97 | 6 |
SGK1 | 105 | 1 |
SmMLCK | 83 | 6 |
Src | 100 | 9 |
SRPK1 | 85 | 6 |
SYK | 31 | 5 |
TAK1 | 102 | 9 |
TAO1 | 105 | 2 |
TBK1 | 110 | 15 |
TrkA | 94 | 4 |
TTK | 100 | 1 |
VEGFR1 | 90 | 2 |
YES1 | 86 | 6 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 65 | 3 |
ASK1 | 98 | 2 |
Aurora A | 94 | 4 |
Aurora B | 62 | 5 |
BRSK1 | 73 | 4 |
BRSK2 | 70 | 2 |
BTK | 72 | 1 |
CAMK1 | 19 | 3 |
CAMKK beta | 82 | 5 |
CDK2-Cyclin A | 54 | 2 |
CHK1 | 56 | 15 |
CHK2 |
8
|
1 |
CK1 delta | 89 | 4 |
CK2 | 81 | 7 |
CLK2 | 68 | 1 |
CSK | 58 | 3 |
DAPK1 | 67 | 9 |
DYRK1A | 86 | 2 |
DYRK2 | 75 | 14 |
DYRK3 | 72 | 7 |
EF2K | 67 | 2 |
EPH-A2 | 88 | 1 |
EPH-A4 | 89 | 11 |
EPH-B1 | 97 | 7 |
EPH-B2 | 100 | 4 |
EPH-B3 | 84 | 5 |
EPH-B4 | 74 | 12 |
ERK1 | 69 | 6 |
ERK2 | 63 | 1 |
ERK8 | 69 | 6 |
FGF-R1 | 83 | 5 |
GCK | 13 | 0 |
GSK3 beta | 58 | 12 |
HER4 | 91 | 8 |
HIPK1 | 80 | 5 |
HIPK2 | 70 | 2 |
HIPK3 | 96 | 6 |
IGF-1R | 61 | 4 |
IKK beta | 81 | 5 |
IKK epsilon | 70 | 13 |
IR | 59 | 6 |
IRAK4 | 69 | 5 |
IRR | 69 | 4 |
JAK2 | 62 | 7 |
JNK1 | 70 | 3 |
JNK2 | 68 | 14 |
JNK3 | 78 | 1 |
Lck | 72 | 7 |
LKB1 | 28 | 6 |
MAPKAP-K2 | 99 | 6 |
MAPKAP-K3 | 93 | 7 |
MARK1 | 77 | 6 |
MARK2 | 82 | 0 |
MARK3 | 65 | 3 |
MARK4 | 81 | 5 |
MEKK1 | 77 | 6 |
MELK | 63 | 8 |
MINK1 | 47 | 1 |
MKK1 | 55 | 8 |
MKK2 | 84 | 0 |
MKK6 | 73 | 3 |
MLK1 | 39 | 4 |
MLK3 | 33 | 5 |
MNK1 | 84 | 4 |
MNK2 | 83 | 3 |
MSK1 | 85 | 5 |
MST2 | 57 | 1 |
MST4 | 86 | 3 |
NEK2a | 78 | 4 |
NEK6 | 94 | 4 |
NUAK1 | 35 | 0 |
p38 alpha MAPK | 84 | 12 |
p38 beta MAPK | 66 | 7 |
p38 delta MAPK | 118 | 6 |
p38 gamma MAPK | 91 | 9 |
PAK2 | 88 | 8 |
PAK4 | 43 | 6 |
PAK5 | 50 | 13 |
PAK6 | 47 | 3 |
PDK1 | 92 | 0 |
PHK | 54 | 3 |
PIM1 | 61 | 0 |
PIM2 | 61 | 1 |
PIM3 | 41 | 3 |
PKA | 98 | 6 |
PKB alpha | 86 | 0 |
PKB beta | 82 | 5 |
PKC alpha | 44 | 2 |
PKC zeta | 74 | 5 |
PKD1 | 28 | 4 |
PLK1 | 98 | 0 |
PRAK | 48 | 1 |
PRK2 | 71 | 5 |
RIPK2 | 68 | 7 |
ROCK 2 | 64 | 1 |
RSK1 | 71 | 1 |
RSK2 | 52 | 4 |
S6K1 | 61 | 9 |
SGK1 | 87 | 2 |
SmMLCK | 74 | 13 |
Src | 71 | 11 |
SRPK1 | 87 | 4 |
SYK |
9
|
1 |
TAK1 | 43 | 2 |
TAO1 | 56 | 3 |
TBK1 | 91 | 11 |
TrkA | 40 | 7 |
TTK | 79 | 11 |
VEGFR1 | 83 | 0 |
YES1 | 50 | 3 |
Kinase | % Activity Remaining | Standard Deviation |
---|---|---|
AMPK | 23 | 3 |
Aurora B | 57 | 4 |
BRSK2 | 55 | 21 |
BTK | 14 | 1 |
CAMK1 |
2
|
0 |
CAMKK beta | 49 | 2 |
CDK2-Cyclin A | 24 | 1 |
CHK1 | 11 | 3 |
CHK2 |
-5
|
0 |
CK1 delta | 42 | 1 |
CK2 | 43 | 0 |
CSK | 66 | 2 |
DYRK1A | 72 | 7 |
DYRK2 | 70 | 1 |
DYRK3 | 48 | 2 |
EF2K | 114 | 10 |
EPH-A2 | 67 | 4 |
EPH-B3 | 81 | 4 |
ERK1 | 34 | 8 |
ERK2 | 30 | 0 |
ERK8 | 11 | 1 |
FGF-R1 | 65 | 6 |
GSK3 beta | 65 | 6 |
HIPK2 | 63 | 7 |
IGF-1R |
3
|
0 |
IKK beta | 66 | 0 |
IKK epsilon | 63 | 2 |
IR | 13 | 3 |
IRR | 46 | 6 |
JNK1 | 71 | 3 |
JNK2 | 99 | 5 |
Lck | 28 | 2 |
MAPKAP-K2 | 32 | 12 |
MARK3 | 25 | 3 |
MELK | 45 | 2 |
MKK1 | 11 | 2 |
MNK1 | 18 | 5 |
MNK2 | 29 | 3 |
MSK1 | 83 | 5 |
MST2 |
10
|
0 |
MST4 | 22 | 3 |
NEK2a | 48 | 2 |
NEK6 | 99 | 0 |
p38 alpha MAPK | 93 | 4 |
p38 beta MAPK | 83 | 2 |
p38 delta MAPK | 58 | 13 |
p38 gamma MAPK | 71 | 1 |
PAK4 |
6
|
0 |
PAK5 |
6
|
0 |
PAK6 | 17 | 2 |
PDK1 | 85 | 3 |
PHK | 15 | 3 |
PIM1 | 15 | 1 |
PIM2 | 53 | 1 |
PIM3 |
5
|
0 |
PKA | 95 | 5 |
PKB alpha | 72 | 3 |
PKB beta | 88 | 3 |
PKC alpha | 22 | 1 |
PKC zeta | 84 | 2 |
PKD1 |
2
|
2 |
PLK1 | 105 | 0 |
PRAK | 16 | 0 |
PRK2 | 35 | 3 |
ROCK 2 | 34 | 5 |
RSK1 | 22 | 3 |
RSK2 | 44 | 0 |
S6K1 | 63 | 4 |
SGK1 | 84 | 2 |
SmMLCK | 35 | 6 |
Src | 13 | 0 |
SRPK1 | 85 | 4 |
SYK |
0
|
0 |
TBK1 | 64 | 0 |
VEGFR1 | 62 | 6 |
YES1 |
9
|
12 |