Inhibitor | TAE684  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
TAE684   C30H40ClN7O3S 614.22 761439-42-3 16038120 NPM-ALK Zhang J. (2012) Bioorg. Med. Chem. Lett. 22 1864–1869 Galkin A.V. (2007) Proc. Natl. Acad. Sci. USA 104 (1) 270-275

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 97 1
AMPK 27 3
ASK1 97 10
Aurora A 15 5
Aurora B 114 23
BRK 21 8
BRSK1 31 11
BRSK2 28 4
BTK 53 7
CAMK1 94 13
CAMKK beta
9
 1
CDK2-Cyclin A 68 6
CHK1 37 12
CHK2
3
 0
CK1 delta 102 1
CK2 87 14
CLK2 14 2
CSK 77 8
DAPK1 98 7
DYRK1A 100 9
DYRK2 105 24
DYRK3 97 4
EF2K 96 20
EIF2AK3 101 3
EPH-A2 70 7
EPH-A4 52 8
EPH-B1 50 13
EPH-B2 83 4
EPH-B3 80 34
EPH-B4 73 2
ERK1 86 16
ERK2 78 17
ERK8 47 4
FGF-R1
10
 0
GCK 45 11
GSK3 beta 104 13
HER4 36 9
HIPK1 105 2
HIPK2 86 10
HIPK3 81 6
IGF-1R
4
 1
IKK beta 98 11
IKK epsilon 89 7
IR 17 2
IRAK1 41 1
IRAK4 43 3
IRR 98 2
JAK2 21 3
JNK1 87 18
JNK2 80 11
JNK3 81 2
Lck 24 8
LKB1 94 16
MAPKAP-K2 115 3
MAPKAP-K3 94 19
MARK1 36 4
MARK2 27 0
MARK3 34 9
MARK4 37 4
MEKK1 109 13
MELK 71 2
MINK1 72 7
MKK1 91 10
MKK2 69 1
MKK6 90 16
MLK1 24 3
MLK3 64 12
MNK1 106 9
MNK2 101 33
MPSK1 102 6
MSK1 80 13
MST2 56 16
MST4 92 26
NEK2a 81 5
NEK6 83 12
NUAK1
10
 6
OSR1 61 23
p38 alpha MAPK 88 2
p38 beta MAPK 100 14
p38 delta MAPK 94 19
p38 gamma MAPK 102 10
PAK2 86 3
PAK4 75 6
PAK5 66 2
PAK6 103 11
PDK1 101 15
PHK
6
 1
PIM1 98 19
PIM2 91 14
PIM3 106 17
PKA 90 17
PKB alpha 102 8
PKB beta 82 16
PKC alpha 109 6
PKC gamma 100 9
PKC zeta 118 7
PKD1 37 15
PLK1 84 6
PRAK 101 1
PRK2 51 18
RIPK2 94 21
ROCK 2 85 17
RSK1 14 3
RSK2 24 2
S6K1 99 16
SGK1 89 11
SmMLCK 78 7
Src 44 10
SRPK1 86 4
STK33 16 3
SYK 85 26
TAK1 62 17
TAO1 61 1
TBK1 93 27
TESK1 120 2
TIE2 18 2
TLK1 100 2
TrkA 41 7
TSSK1
10
 1
TTBK1 88 15
TTK 73 18
VEGFR1 22 8
YES1 13 5
ZAP70 113 17
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 39 2
AMPK 34 0
ASK1 78 3
Aurora A
2
 0
Aurora B 76 7
BRK
5
 0
BRSK1
8
 2
BRSK2 11 1
BTK 38 4
CAMK1 37 2
CAMKK beta
5
 1
CDK2-Cyclin A 38 12
CHK1 12 1
CHK2
3
 0
CK1 delta 102 3
CK2 75 2
CLK2
3
 0
CSK 33 3
DAPK1 79 1
DYRK1A 77 6
DYRK2 106 8
DYRK3 94 15
EF2K 94 3
EIF2AK3 95 4
EPH-A2 27 1
EPH-A4 13 3
EPH-B1
7
 2
EPH-B2 23 6
EPH-B3 26 3
EPH-B4 23 7
ERK1 53 0
ERK2 40 2
ERK8 26 5
FGF-R1
2
 0
GCK 17 0
GSK3 beta 92 9
HER4
7
 1
HIPK1 97 8
HIPK2 89 20
HIPK3 83 4
IGF-1R
3
 0
IKK beta 107 14
IKK epsilon 86 14
IR 22 8
IRAK1 12 4
IRAK4 16 4
IRR 66 0
JAK2
8
 2
JNK1 28 4
JNK2 62 38
JNK3 38 3
Lck
7
 1
LKB1 77 0
MAPKAP-K2 118 13
MAPKAP-K3 100 2
MARK1 13 2
MARK2
6
 1
MARK3
7
 3
MARK4 19 3
MEKK1 104 8
MELK 21 6
MINK1 13 1
MKK1 30 3
MKK2 30 8
MKK6 75 16
MLK1
8
 2
MLK3 27 2
MNK1 97 18
MNK2 60 2
MPSK1 96 13
MSK1 45 2
MST2 23 4
MST4 55 3
NEK2a 43 2
NEK6 80 6
NUAK1
3
 0
OSR1 16 2
p38 alpha MAPK 79 9
p38 beta MAPK 92 2
p38 delta MAPK 87 5
p38 gamma MAPK 98 17
PAK2 57 10
PAK4 44 4
PAK5 35 6
PAK6 85 1
PDK1 87 16
PHK
2
 0
PIM1 101 9
PIM2 107 6
PIM3 104 22
PKA 64 13
PKB alpha 109 2
PKB beta 76 3
PKC alpha 122 31
PKC gamma 101 12
PKC zeta 99 1
PKD1 12 1
PLK1 38 3
PRAK 110 21
PRK2 18 5
RIPK2 59 0
ROCK 2 40 13
RSK1
8
 2
RSK2 15 5
S6K1 68 15
SGK1 88 1
SmMLCK 43 8
Src 20 17
SRPK1 46 9
STK33 16 1
SYK 28 1
TAK1 15 2
TAO1 23 12
TBK1 71 2
TESK1 85 19
TIE2
5
 1
TLK1 114 10
TrkA 16 5
TSSK1
8
 2
TTBK1 101 28
TTK 47 0
VEGFR1 12 1
YES1
3
 0
ZAP70 129 52