Inhibitor | GDC-0941  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	90	5
Aurora B	108	18
BRSK2	83	1
BTK	89	0
CAMK1	72	11
CAMKK beta	87	5
CDK2-Cyclin A	88	2
CHK1	92	8
CHK2	85	0
CK1 delta	106	3
CK2	99	3
CSK	97	5
DYRK1A	99	4
DYRK2	93	5
DYRK3	82	2
EF2K	81	0
EPH-A2	104	2
EPH-B3	96	1
ERK1	96	14
ERK2	86	8
ERK8	95	32
FGF-R1	92	1
GSK3 beta	76	2
HIPK2	75	9
IGF-1R	95	7
IKK beta	200	131
IKK epsilon	77	7
IR	115	7
IRR	79	6
JNK1	92	0
JNK2	99	10
Lck	91	12
MAPKAP-K2	85	3
MARK3	84	8
MELK	86	6
MKK1	12	0
MNK1	89	2
MNK2	102	1
MSK1	83	3
MST2	94	4
MST4	110	5
NEK2a	89	4
NEK6	79	4
p38 alpha MAPK	67	12
p38 beta MAPK	88	5
p38 delta MAPK	86	10
p38 gamma MAPK	98	2
PAK4	95	0
PAK5	95	3
PAK6	84	1
PDK1	97	0
PHK	101	1
PIM1	98	0
PIM2	97	5
PIM3	92	5
PKA	93	3
PKB alpha	98	4
PKB beta	75	8
PKC alpha	98	4
PKC zeta	79	9
PKD1	84	4
PLK1	91	6
PRAK	95	13
PRK2	85	8
ROCK 2	87	4
RSK1	85	7
RSK2	89	11
S6K1	89	3
SGK1	79	1
SmMLCK	99	4
Src	92	0
SRPK1	101	9
SYK	105	11
TBK1	90	4
VEGFR1	89	2
YES1	87	5

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	76	8
ASK1	83	2
Aurora A	94	12
Aurora B	82	9
BRSK1	92	8
BRSK2	87	0
BTK	79	4
CAMK1	82	11
CAMKK beta	80	0
CDK2-Cyclin A	103	6
CHK1	85	3
CHK2	99	5
CK1 delta	83	2
CK2	105	3
CLK2	30	2
CSK	83	10
DAPK1	77	11
DYRK1A	92	0
DYRK2	63	3
DYRK3	85	3
EF2K	98	4
EPH-A2	100	11
EPH-A4	107	8
EPH-B1	101	9
EPH-B2	94	1
EPH-B3	92	0
EPH-B4	88	12
ERK1	93	10
ERK2	72	3
ERK8	79	1
FGF-R1	91	12
GCK	83	4
GSK3 beta	69	6
HER4	77	8
HIPK1	83	2
HIPK2	52	2
HIPK3	81	8
IGF-1R	84	0
IKK beta	87	0
IKK epsilon	83	3
IR	93	7
IRAK4	75	1
IRR	81	15
JAK2	83	4
JNK1	97	3
JNK2	83	3
JNK3	72	4
Lck	100	6
LKB1	52	5
MAPKAP-K2	82	2
MAPKAP-K3	83	1
MARK1	97	1
MARK2	79	6
MARK3	99	0
MARK4	93	1
MEKK1	92	3
MELK	72	15
MINK1	76	1
MKK1	80	12
MKK2	82	0
MKK6	77	10
MLK1	74	3
MLK3	74	8
MNK1	95	4
MNK2	91	2
MSK1	72	1
MST2	98	11
MST4	93	2
NEK2a	78	9
NEK6	100	7
NUAK1	79	4
p38 alpha MAPK	78	4
p38 beta MAPK	90	1
p38 delta MAPK	89	9
p38 gamma MAPK	96	5
PAK2	95	5
PAK4	85	0
PAK5	80	0
PAK6	89	2
PDK1	90	9
PHK	98	7
PIM1	82	13
PIM2	87	10
PIM3	87	0
PKA	103	3
PKB alpha	89	7
PKB beta	63	8
PKC alpha	99	10
PKC zeta	82	3
PKD1	79	10
PLK1	96	5
PRAK	100	6
PRK2	71	6
RIPK2	84	1
ROCK 2	73	2
RSK1	86	2
RSK2	82	0
S6K1	81	2
SGK1	93	6
SmMLCK	70	9
Src	76	6
SRPK1	90	1
SYK	100	7
TAK1	80	8
TAO1	83	5
TBK1	80	0
TrkA	67	6
TTK	79	1
VEGFR1	74	12
YES1	84	2

Screen Conc: 10.00µM

Kinase	% Activity Remaining	Standard Deviation
AMPK	83	4
Aurora B	94	4
BRSK2	67	1
BTK	71	3
CAMK1	69	26
CAMKK beta	54	0
CDK2-Cyclin A	36	4
CHK1	88	16
CHK2	73	6
CK1 delta	95	3
CK2	87	3
CSK	80	10
DYRK1A	69	5
DYRK2	38	0
DYRK3	63	10
EF2K	76	11
EPH-A2	90	3
EPH-B3	99	6
ERK1	96	14
ERK2	53	19
ERK8	15	0
FGF-R1	55	1
GSK3 beta	59	5
HIPK2	26	6
IGF-1R	46	16
IKK beta	145	95
IKK epsilon	74	0
IR	82	1
IRR	33	18
JNK1	34	7
JNK2	48	2
Lck	64	0
MAPKAP-K2	75	11
MARK3	75	12
MELK	67	8
MKK1	11	0
MNK1	80	4
MNK2	96	2
MSK1	59	2
MST2	86	0
MST4	75	3
NEK2a	96	4
NEK6	65	11
p38 alpha MAPK	64	11
p38 beta MAPK	84	2
p38 delta MAPK	75	0
p38 gamma MAPK	75	0
PAK4	90	0
PAK5	83	8
PAK6	74	3
PDK1	87	7
PHK	79	18
PIM1	60	6
PIM2	73	15
PIM3	66	2
PKA	85	4
PKB alpha	85	0
PKB beta	57	10
PKC alpha	98	11
PKC zeta	77	2
PKD1	79	8
PLK1	76	3
PRAK	108	1
PRK2	84	12
ROCK 2	74	3
RSK1	52	0
RSK2	69	15
S6K1	46	3
SGK1	45	1
SmMLCK	67	8
Src	58	10
SRPK1	92	18
SYK	80	19
TBK1	98	6
VEGFR1	78	4
YES1	40	7