Inhibitor | Genentech LRRK2 inhibitor compound 19  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
Genentech LRRK2 inhibitor compound 19   C20H21F4N5O3 455.41 LRRK2 Estrada AA (2012) J Med Chem 55(22) 9416-33

Screening Results Chart

Screening Results Tables

Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 106 18
AMPK 92 20
AMPK (hum) 82 12
ASK1 66 8
Aurora A 105 12
Aurora B 68 8
BRK 53 0
BRSK1 85 1
BRSK2 88 5
BTK 115 11
CAMK1 92 8
CAMKK beta 40 8
CDK2-Cyclin A 94 14
CDK9-Cyclin T1 87 3
CHK1 58 1
CHK2 18 1
CK1 delta 95 1
CK1 gamma 2 90 6
CK2 96 15
CLK2 36 1
CSK 102 17
DAPK1 53 9
DDR2 105 9
DYRK1A 78 5
DYRK2 40 7
DYRK3 88 6
EF2K 103 0
EIF2AK3 87 4
EPH-A2 81 17
EPH-A4 86 7
EPH-B1 93 4
EPH-B2 92 8
EPH-B3 91 5
EPH-B4 94 0
ERK1 79 8
ERK2 95 7
ERK5 66 1
ERK8 81 4
FGF-R1 97 10
GCK 73 0
GSK3 beta 73 19
HER4 74 5
HIPK1 92 1
HIPK2 70 8
HIPK3 101 5
IGF-1R 35 1
IKK beta 97 10
IKK epsilon 94 7
IR 50 4
IRAK1 98 2
IRAK4 90 6
IRR 84 3
JAK2 79 1
JNK1 83 7
JNK2 108 3
JNK3 80 2
Lck 104 23
LKB1 88 7
MAP4K3 76 10
MAP4K5 107 9
MAPKAP-K2 102 2
MAPKAP-K3 108 5
MARK1 88 4
MARK2 100 12
MARK3 91 9
MARK4 95 5
MEKK1 90 9
MELK 91 10
MINK1 124 9
MKK1 95 0
MKK2 118 2
MKK6 71 0
MLK1 39 11
MLK3 35 4
MNK1 74 5
MNK2 58 2
MPSK1 115 16
MSK1 85 2
MST2 111 13
MST3 96 8
MST4 89 5
NEK2a 97 7
NEK6 112 1
NUAK1 41 4
OSR1 95 1
p38 alpha MAPK 84 9
p38 beta MAPK 98 9
p38 delta MAPK 97 6
p38 gamma MAPK 98 1
PAK2 89 3
PAK4 85 9
PAK5 94 1
PAK6 94 10
PDGFRA 81 9
PDK1 104 16
PHK 45 11
PIM1 101 1
PIM2 100 1
PIM3 101 0
PKA 102 10
PKB alpha 93 3
PKB beta 99 4
PKC alpha 96 3
PKC gamma 100 25
PKC zeta 101 2
PKD1 41 7
PLK1 78 5
PRAK 77 9
PRK2 84 9
RIPK2 94 8
ROCK 2 95 2
RSK1 54 6
RSK2 77 1
S6K1 89 1
SGK1 88 13
SIK2 84 10
SIK3 95 3
SmMLCK 44 6
Src 107 19
SRPK1 84 4
STK33 47 3
SYK 87 24
TAK1 11 2
TAO1 99 6
TBK1 57 22
TESK1 102 4
TGFBR1 99 0
TIE2 85 5
TLK1 106 5
TrkA 70 8
TSSK1 31 4
TTBK1 96 5
TTBK2 91 7
TTK 56 7
ULK1 98 7
ULK2 88 5
VEGFR1 55 3
WNK1 97 0
YES1 89 7
ZAP70 88 6
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 97 10
AMPK 70 11
AMPK (hum) 44 17
ASK1 13 1
Aurora A 81 13
Aurora B 24 2
BRK 22 3
BRSK1 69 11
BRSK2 51 0
BTK 98 24
CAMK1 51 4
CAMKK beta
10
 1
CDK2-Cyclin A 72 6
CDK9-Cyclin T1 90 10
CHK1 25 0
CHK2
3
 0
CK1 delta 67 2
CK1 gamma 2 89 5
CK2 74 7
CLK2
5
 2
CSK 101 12
DAPK1 11 4
DDR2 100 8
DYRK1A 38 6
DYRK2
9
 2
DYRK3 51 9
EF2K 107 1
EIF2AK3 82 3
EPH-A2 93 6
EPH-A4 98 6
EPH-B1 91 14
EPH-B2 97 3
EPH-B3 105 11
EPH-B4 94 3
ERK1 49 5
ERK2 55 2
ERK5 42 3
ERK8 28 3
FGF-R1 104 6
GCK 25 6
GSK3 beta 43 1
HER4 65 5
HIPK1 49 5
HIPK2 28 9
HIPK3 70 20
IGF-1R
8
 1
IKK beta 89 4
IKK epsilon 55 8
IR
3
 0
IRAK1 94 4
IRAK4 93 9
IRR 67 6
JAK2 52 3
JNK1 47 6
JNK2 84 6
JNK3 48 1
Lck 102 15
LKB1 92 7
MAP4K3 36 0
MAP4K5 91 2
MAPKAP-K2 97 3
MAPKAP-K3 124 9
MARK1 85 18
MARK2 81 1
MARK3 61 6
MARK4 52 4
MEKK1 109 15
MELK 39 3
MINK1 109 12
MKK1 81 7
MKK2 98 6
MKK6 31 2
MLK1
7
 0
MLK3
9
 1
MNK1 26 0
MNK2 22 4
MPSK1 101 14
MSK1 65 7
MST2 92 3
MST3 85 2
MST4 87 4
NEK2a 72 19
NEK6 90 6
NUAK1
9
 1
OSR1 51 1
p38 alpha MAPK 119 2
p38 beta MAPK 101 10
p38 delta MAPK 79 20
p38 gamma MAPK 96 3
PAK2 88 2
PAK4 42 7
PAK5 79 1
PAK6 94 6
PDGFRA 76 4
PDK1 88 7
PHK
8
 0
PIM1 94 3
PIM2 107 6
PIM3 78 0
PKA 107 22
PKB alpha 97 6
PKB beta 98 3
PKC alpha 101 2
PKC gamma 98 21
PKC zeta 86 3
PKD1
10
 3
PLK1 40 6
PRAK 49 3
PRK2 82 6
RIPK2 79 2
ROCK 2 78 1
RSK1 14 1
RSK2 25 7
S6K1 68 2
SGK1 70 7
SIK2 34 12
SIK3 93 9
SmMLCK
8
 2
Src 81 0
SRPK1 69 5
STK33 30 8
SYK 44 11
TAK1
2
 0
TAO1 80 3
TBK1 26 5
TESK1 118 3
TGFBR1 103 3
TIE2 91 5
TLK1 96 8
TrkA 54 12
TSSK1
7
 0
TTBK1 93 6
TTBK2 97 13
TTK 31 8
ULK1 56 2
ULK2 70 1
VEGFR1 14 1
WNK1 106 5
YES1 110 8
ZAP70 86 1