| Compound name | Brutto | MW | CAS | PubChem CID | Action | Reference | Reference |
|---|---|---|---|---|---|---|---|
| RO-3306 | C₁₈H₁₃N₃OS₂ | 351.50 | 872573-93-8 | 71433937 | Cdk1 | Vassilev, L.T. (2006) Proc. Natl. Acad. Sci. USA 103 10660 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL | 100 | 15 |
| AMPK (hum) | 40 | 1 |
| ASK1 | 66 | 2 |
| Aurora A | 117 | 5 |
| Aurora B | 49 | 5 |
| BRK | 112 | 3 |
| BRSK1 | 59 | 9 |
| BRSK2 | 60 | 6 |
| BTK | 103 | 8 |
| CAMK1 | 96 | 10 |
| CAMKK beta | 21 | 1 |
| CDK2-Cyclin A | 21 | 0 |
| CDK9-Cyclin T1 | 82 | 5 |
| CHK1 | 37 | 1 |
| CHK2 | 36 | 2 |
| CK1 delta | 81 | 15 |
| CK1 gamma 2 | 88 | 8 |
| CK2 | 66 | 7 |
| CLK2 |
6
|
0 |
| CSK | 93 | 16 |
| DAPK1 | 62 | 4 |
| DDR2 | 92 | 27 |
| DYRK1A |
2
|
0 |
| DYRK2 | 20 | 3 |
| DYRK3 | 14 | 1 |
| EF2K | 93 | 2 |
| EIF2AK3 | 98 | 7 |
| EPH-A2 | 105 | 5 |
| EPH-A4 | 115 | 1 |
| EPH-B1 | 81 | 21 |
| EPH-B2 | 99 | 4 |
| EPH-B3 | 101 | 2 |
| EPH-B4 | 95 | 11 |
| ERK1 | 68 | 1 |
| ERK2 | 80 | 16 |
| ERK5 | 40 | 1 |
| ERK8 |
8
|
0 |
| FGF-R1 | 93 | 3 |
| GCK |
8
|
1 |
| GSK3 beta | 64 | 6 |
| HER4 | 81 | 17 |
| HIPK1 | 62 | 9 |
| HIPK2 | 43 | 2 |
| HIPK3 | 52 | 5 |
| IGF-1R | 49 | 1 |
| IKK beta | 80 | 9 |
| IKK epsilon | 64 | 6 |
| IR | 97 | 7 |
| IRAK1 | 25 | 2 |
| IRAK4 | 83 | 8 |
| IRR | 86 | 9 |
| JAK2 | 97 | 5 |
| JNK1 | 89 | 8 |
| JNK2 | 89 | 12 |
| JNK3 | 95 | 13 |
| Lck | 93 | 3 |
| LKB1 | 90 | 6 |
| MAP4K3 | 53 | 3 |
| MAP4K5 | 69 | 2 |
| MAPKAP-K2 | 86 | 11 |
| MAPKAP-K3 | 90 | 14 |
| MARK1 | 81 | 3 |
| MARK2 | 97 | 11 |
| MARK3 | 75 | 2 |
| MARK4 | 81 | 3 |
| MEKK1 | 96 | 8 |
| MELK | 52 | 1 |
| MINK1 | 12 | 1 |
| MKK1 | 52 | 1 |
| MKK2 | 78 | 20 |
| MKK6 | 88 | 7 |
| MLK1 | 88 | 4 |
| MLK3 | 63 | 7 |
| MNK1 | 63 | 0 |
| MNK2 | 27 | 4 |
| MPSK1 | 99 | 9 |
| MSK1 | 65 | 6 |
| MST2 | 85 | 6 |
| MST3 | 80 | 2 |
| MST4 | 54 | 8 |
| NEK2a | 49 | 2 |
| NEK6 | 101 | 24 |
| NUAK1 | 44 | 1 |
| OSR1 | 103 | 1 |
| p38 alpha MAPK | 93 | 4 |
| p38 beta MAPK | 101 | 11 |
| p38 delta MAPK | 68 | 12 |
| p38 gamma MAPK | 26 | 2 |
| PAK2 | 100 | 9 |
| PAK4 | 79 | 5 |
| PAK5 | 98 | 4 |
| PAK6 | 102 | 9 |
| PDGFRA | 103 | 9 |
| PDK1 | 102 | 34 |
| PHK | 50 | 2 |
| PIM1 | 12 | 1 |
| PIM2 | 92 | 1 |
| PIM3 | 50 | 7 |
| PINK | 107 | 6 |
| PKA | 89 | 0 |
| PKB alpha | 86 | 5 |
| PKB beta | 78 | 6 |
| PKC alpha | 111 | 1 |
| PKC gamma | 69 | 1 |
| PKC zeta | 114 | 4 |
| PKD1 | 38 | 4 |
| PLK1 | 95 | 8 |
| PRAK | 110 | 24 |
| PRK2 |
8
|
0 |
| RIPK2 | 12 | 1 |
| ROCK 2 | 34 | 1 |
| RSK1 | 49 | 1 |
| RSK2 | 61 | 2 |
| S6K1 | 43 | 11 |
| SGK1 | 51 | 0 |
| SIK2 | 92 | 4 |
| SIK3 | 83 | 4 |
| SmMLCK | 43 | 8 |
| Src | 90 | 9 |
| SRPK1 | 89 | 8 |
| STK33 | 72 | 15 |
| SYK | 106 | 7 |
| TAK1 | 83 | 2 |
| TAO1 | 51 | 6 |
| TBK1 | 60 | 8 |
| TESK1 | 72 | 16 |
| TGFBR1 | 96 | 9 |
| TIE2 | 78 | 6 |
| TLK1 | 113 | 8 |
| TrkA | 96 | 15 |
| TSSK1 | 41 | 3 |
| TTBK1 | 88 | 8 |
| TTBK2 | 103 | 0 |
| TTK | 65 | 2 |
| ULK1 | 89 | 5 |
| ULK2 | 77 | 10 |
| VEGFR1 | 59 | 1 |
| WNK1 | 105 | 3 |
| YES1 | 82 | 0 |
| ZAP70 | 96 | 5 |
| Kinase | % Activity Remaining | Standard Deviation |
|---|---|---|
| ABL | 70 | 9 |
| AMPK (hum) |
10
|
1 |
| ASK1 | 26 | 0 |
| Aurora A | 127 | 20 |
| Aurora B | 13 | 4 |
| BRK | 115 | 6 |
| BRSK1 | 23 | 1 |
| BRSK2 | 21 | 2 |
| BTK | 78 | 6 |
| CAMK1 | 73 | 5 |
| CAMKK beta |
7
|
0 |
| CDK2-Cyclin A |
5
|
0 |
| CDK9-Cyclin T1 | 42 | 1 |
| CHK1 | 13 | 1 |
| CHK2 |
8
|
0 |
| CK1 delta | 86 | 3 |
| CK1 gamma 2 | 49 | 4 |
| CK2 | 20 | 3 |
| CLK2 |
1
|
0 |
| CSK | 81 | 1 |
| DAPK1 | 26 | 1 |
| DDR2 | 100 | 3 |
| DYRK1A |
1
|
0 |
| DYRK2 |
4
|
0 |
| DYRK3 |
4
|
0 |
| EF2K | 89 | 4 |
| EIF2AK3 | 102 | 16 |
| EPH-A2 | 98 | 6 |
| EPH-A4 | 107 | 9 |
| EPH-B1 | 75 | 8 |
| EPH-B2 | 93 | 14 |
| EPH-B3 | 99 | 6 |
| EPH-B4 | 108 | 12 |
| ERK1 | 27 | 0 |
| ERK2 | 44 | 4 |
| ERK5 | 24 | 1 |
| ERK8 |
2
|
1 |
| FGF-R1 | 88 | 1 |
| GCK |
3
|
1 |
| GSK3 beta | 27 | 4 |
| HER4 | 81 | 13 |
| HIPK1 | 18 | 3 |
| HIPK2 | 13 | 0 |
| HIPK3 | 18 | 2 |
| IGF-1R | 46 | 8 |
| IKK beta | 71 | 2 |
| IKK epsilon | 16 | 0 |
| IR | 90 | 4 |
| IRAK1 |
5
|
1 |
| IRAK4 | 41 | 0 |
| IRR | 71 | 6 |
| JAK2 | 41 | 2 |
| JNK1 | 99 | 8 |
| JNK2 | 78 | 8 |
| JNK3 | 96 | 11 |
| Lck | 63 | 2 |
| LKB1 | 58 | 4 |
| MAP4K3 | 11 | 1 |
| MAP4K5 | 35 | 5 |
| MAPKAP-K2 | 40 | 5 |
| MAPKAP-K3 | 77 | 2 |
| MARK1 | 48 | 3 |
| MARK2 | 83 | 6 |
| MARK3 | 35 | 4 |
| MARK4 | 73 | 4 |
| MEKK1 | 103 | 2 |
| MELK | 12 | 2 |
| MINK1 |
4
|
0 |
| MKK1 | 17 | 4 |
| MKK2 | 37 | 4 |
| MKK6 | 81 | 2 |
| MLK1 | 55 | 2 |
| MLK3 | 30 | 5 |
| MNK1 | 43 | 18 |
| MNK2 | 14 | 7 |
| MPSK1 | 119 | 17 |
| MSK1 | 24 | 2 |
| MST2 | 48 | 13 |
| MST3 | 67 | 4 |
| MST4 | 22 | 2 |
| NEK2a |
10
|
2 |
| NEK6 | 108 | 11 |
| NUAK1 | 12 | 0 |
| OSR1 | 104 | 1 |
| p38 alpha MAPK | 95 | 11 |
| p38 beta MAPK | 96 | 9 |
| p38 delta MAPK | 25 | 1 |
| p38 gamma MAPK | 11 | 2 |
| PAK2 | 82 | 7 |
| PAK4 | 35 | 7 |
| PAK5 | 62 | 0 |
| PAK6 | 61 | 2 |
| PDGFRA | 96 | 10 |
| PDK1 | 98 | 19 |
| PHK | 22 | 1 |
| PIM1 |
2
|
0 |
| PIM2 | 45 | 3 |
| PIM3 | 14 | 3 |
| PINK | 112 | 9 |
| PKA | 48 | 4 |
| PKB alpha | 71 | 1 |
| PKB beta | 57 | 4 |
| PKC alpha | 88 | 6 |
| PKC gamma | 22 | 1 |
| PKC zeta | 99 | 16 |
| PKD1 | 15 | 0 |
| PLK1 | 107 | 4 |
| PRAK | 76 | 22 |
| PRK2 |
3
|
1 |
| RIPK2 |
5
|
1 |
| ROCK 2 |
10
|
0 |
| RSK1 | 15 | 1 |
| RSK2 | 37 | 6 |
| S6K1 | 16 | 0 |
| SGK1 | 14 | 1 |
| SIK2 | 54 | 4 |
| SIK3 | 55 | 0 |
| SmMLCK | 14 | 0 |
| Src | 77 | 5 |
| SRPK1 | 79 | 7 |
| STK33 | 34 | 2 |
| SYK | 116 | 11 |
| TAK1 | 53 | 1 |
| TAO1 | 13 | 2 |
| TBK1 | 20 | 2 |
| TESK1 | 82 | 4 |
| TGFBR1 | 115 | 3 |
| TIE2 | 62 | 0 |
| TLK1 | 120 | 14 |
| TrkA | 60 | 6 |
| TSSK1 |
9
|
0 |
| TTBK1 | 92 | 2 |
| TTBK2 | 102 | 12 |
| TTK | 51 | 11 |
| ULK1 | 47 | 4 |
| ULK2 | 38 | 0 |
| VEGFR1 | 22 | 4 |
| WNK1 | 109 | 15 |
| YES1 | 46 | 2 |
| ZAP70 | 104 | 1 |