Inhibitor | R-406  

Compound name Brutto MW CAS PubChem CID Action Reference Reference
R-406   C23H24FN5O5 469.46 841290-80-0 11213558 SYK Braselmann S. (2006) J Pharmacol Exp Ther. 319(3) 998-1008

Screening Results Chart

Screening Results Tables

Screen Conc: 0.10µM
Kinase % Activity Remaining Standard Deviation
ABL 101 10
AMPK (hum) 95 2
ASK1 101 3
Aurora A 49 5
Aurora B 43 4
BRK 76 2
BRSK1 96 2
BRSK2 102 4
BTK 34 5
CAMK1 92 9
CAMKK beta 109 11
CDK2-Cyclin A 77 2
CDK9-Cyclin T1 105 1
CHK1 94 5
CHK2 86 7
CK1 delta 101 3
CK1 gamma 2 98 6
CK2 77 3
CLK2 107 11
CSK 85 8
DAPK1 50 6
DDR2 24 9
DYRK1A 87 7
DYRK2 102 13
DYRK3 92 2
EF2K 97 7
EIF2AK3 97 4
EPH-A2 77 3
EPH-A4 64 7
EPH-B1 91 3
EPH-B2 106 7
EPH-B3 97 9
EPH-B4 85 2
ERK1 96 4
ERK2 113 1
ERK5 76 12
ERK8 61 6
FGF-R1 49 11
GCK 90 5
GSK3 beta 73 5
HER4 77 11
HIPK1 92 3
HIPK2 95 2
HIPK3 114 4
IGF-1R 126 12
IKK beta 62 8
IKK epsilon 25 1
IR 106 7
IRAK1 24 0
IRAK4 66 7
IRR 74 1
JAK2
3
 1
JNK1 86 13
JNK2 67 8
JNK3 73 2
Lck 27 9
LKB1 87 5
MAP4K3 89 6
MAP4K5 114 16
MAPKAP-K2 98 2
MAPKAP-K3 98 7
MARK1 103 10
MARK2 89 14
MARK3 78 8
MARK4 76 0
MEKK1 89 11
MELK 91 3
MINK1 96 12
MKK1 71 1
MKK2 81 13
MKK6 94 0
MLK1
4
 1
MLK3
8
 0
MNK1 84 1
MNK2 75 2
MPSK1 106 2
MSK1 95 8
MST2 94 15
MST3 114 0
MST4 103 8
NEK2a 87 6
NEK6 98 3
NUAK1 75 8
OSR1 92 2
p38 alpha MAPK 99 5
p38 beta MAPK 103 10
p38 delta MAPK 74 9
p38 gamma MAPK 120 13
PAK2 101 2
PAK4 52 1
PAK5 80 4
PAK6 104 2
PDGFRA 39 2
PDK1 67 6
PHK 99 4
PIM1 100 9
PIM2 94 1
PIM3 97 2
PINK 85 24
PKA 106 4
PKB alpha 90 10
PKB beta 109 15
PKC alpha 100 1
PKC gamma 96 9
PKC zeta 105 6
PKD1 89 2
PLK1 81 1
PRAK 99 1
PRK2 93 9
RIPK2 74 4
ROCK 2 90 1
RSK1 63 12
RSK2 98 14
S6K1 66 1
SGK1 100 10
SIK2 45 8
SIK3 97 3
SmMLCK 91 10
Src 13 4
SRPK1 95 1
STK33 89 8
SYK 38 1
TAK1 56 2
TAO1 97 2
TBK1 40 7
TESK1 102 4
TGFBR1 98 5
TIE2 73 7
TLK1 90 7
TrkA 26 2
TSSK1 44 1
TTBK1 112 6
TTBK2 118 6
TTK 85 1
ULK1 13 1
ULK2 29 4
VEGFR1 11 2
WNK1 107 15
YES1 48 4
ZAP70 88 9
Screen Conc: 1.00µM
Kinase % Activity Remaining Standard Deviation
ABL 89 14
AMPK (hum) 42 3
ASK1 94 3
Aurora A
10
 6
Aurora B 11 0
BRK 55 6
BRSK1 93 0
BRSK2 94 3
BTK 12 0
CAMK1 55 9
CAMKK beta 66 7
CDK2-Cyclin A 32 1
CDK9-Cyclin T1 94 7
CHK1 59 2
CHK2 30 2
CK1 delta 99 13
CK1 gamma 2 100 3
CK2 19 1
CLK2 28 0
CSK 15 2
DAPK1 26 6
DDR2
5
 2
DYRK1A 47 11
DYRK2 58 2
DYRK3 82 4
EF2K 101 6
EIF2AK3 60 1
EPH-A2 30 0
EPH-A4 17 2
EPH-B1 22 0
EPH-B2 49 12
EPH-B3 83 8
EPH-B4 61 0
ERK1 85 1
ERK2 108 10
ERK5 39 1
ERK8 19 3
FGF-R1
8
 0
GCK 58 1
GSK3 beta 24 2
HER4 24 0
HIPK1 40 1
HIPK2 83 0
HIPK3 98 7
IGF-1R 30 2
IKK beta 28 7
IKK epsilon
3
 0
IR 62 2
IRAK1
4
 1
IRAK4 21 7
IRR 55 16
JAK2
2
 1
JNK1 25 2
JNK2 17 4
JNK3 22 1
Lck
4
 1
LKB1 33 1
MAP4K3 34 4
MAP4K5 89 15
MAPKAP-K2 103 5
MAPKAP-K3 110 14
MARK1 84 5
MARK2 53 5
MARK3 24 2
MARK4 52 5
MEKK1 89 5
MELK 52 1
MINK1 77 0
MKK1 18 1
MKK2 39 3
MKK6 85 9
MLK1
2
 1
MLK3
3
 0
MNK1 55 3
MNK2 21 1
MPSK1 54 11
MSK1 78 3
MST2 69 13
MST3 100 7
MST4 67 6
NEK2a 38 3
NEK6 58 2
NUAK1 22 1
OSR1 61 11
p38 alpha MAPK 87 10
p38 beta MAPK 85 15
p38 delta MAPK 21 1
p38 gamma MAPK 69 14
PAK2 74 3
PAK4
9
 1
PAK5 27 3
PAK6 50 3
PDGFRA
9
 2
PDK1 24 2
PHK 62 1
PIM1 96 10
PIM2 84 8
PIM3 77 4
PINK 94 19
PKA 57 4
PKB alpha 78 5
PKB beta 110 2
PKC alpha 82 9
PKC gamma 78 4
PKC zeta 103 1
PKD1 69 1
PLK1 38 3
PRAK 102 5
PRK2 48 4
RIPK2 24 2
ROCK 2 50 4
RSK1 29 7
RSK2 54 7
S6K1 36 2
SGK1 94 15
SIK2
9
 1
SIK3 63 10
SmMLCK 91 4
Src
3
 2
SRPK1 100 6
STK33 44 7
SYK
6
 2
TAK1
10
 12
TAO1 52 2
TBK1
9
 1
TESK1 49 3
TGFBR1 107 5
TIE2 40 1
TLK1 54 0
TrkA
5
 1
TSSK1
10
 0
TTBK1 106 15
TTBK2 120 3
TTK 54 1
ULK1
3
 0
ULK2
7
 0
VEGFR1
5
 2
WNK1 94 11
YES1 12 1
ZAP70 36 2
Screen Conc: 10.00µM
Kinase % Activity Remaining Standard Deviation
ABL 110 6
AMPK (hum) 53 2
ASK1 109 16
Aurora A 20 8
Aurora B 12 1
BRK 70 21
BRSK1 103 12
BRSK2 103 2
BTK
9
 1
CAMK1 33 4
CAMKK beta 48 10
CDK2-Cyclin A 66 9
CDK9-Cyclin T1 98 5
CHK1 55 3
CHK2 31 3
CK1 delta 105 15
CK1 gamma 2 98 5
CK2 16 1
CLK2 71 3
CSK
10
 1
DAPK1 32 9
DDR2
8
 1
DYRK1A 50 14
DYRK2 53 2
DYRK3 58 9
EF2K 114 1
EIF2AK3 22 1
EPH-A2 17 8
EPH-A4 20 5
EPH-B1 11 0
EPH-B2 14 2
EPH-B3 50 7
EPH-B4 81 1
ERK1 96 1
ERK2 97 7
ERK5 39 1
ERK8 21 0
FGF-R1
3
 0
GCK 73 10
GSK3 beta 23 1
HER4
7
 0
HIPK1 72 11
HIPK2 32 2
HIPK3 98 20
IGF-1R 63 9
IKK beta 39 2
IKK epsilon
1
 0
IR 44 2
IRAK1
2
 0
IRAK4
6
 1
IRR 72 14
JAK2
-8
 12
JNK1 22 2
JNK2 13 2
JNK3 34 2
Lck
5
 0
LKB1 66 4
MAP4K3
2
 0
MAP4K5 56 7
MAPKAP-K2 97 14
MAPKAP-K3 116 18
MARK1 98 3
MARK2 75 1
MARK3
10
 5
MARK4 25 2
MEKK1 101 4
MELK 18 2
MINK1 83 9
MKK1 27 12
MKK2 59 14
MKK6 74 0
MLK1
1
 0
MLK3
2
 0
MNK1 60 7
MNK2 18 1
MPSK1 24 0
MSK1 92 2
MST2 30 2
MST3 117 12
MST4 27 1
NEK2a
8
 0
NEK6 49 9
NUAK1
5
 1
OSR1 71 5
p38 alpha MAPK 94 18
p38 beta MAPK 81 1
p38 delta MAPK 32 1
p38 gamma MAPK 38 4
PAK2 28 2
PAK4
2
 0
PAK5
9
 1
PAK6 55 15
PDGFRA 16 2
PDK1 23 1
PHK 46 6
PIM1 102 12
PIM2 95 6
PIM3 38 1
PINK 84 13
PKA 62 7
PKB alpha 122 29
PKB beta 104 1
PKC alpha 45 8
PKC gamma 47 8
PKC zeta 83 4
PKD1 56 19
PLK1 11 0
PRAK 92 3
PRK2 20 3
RIPK2 23 2
ROCK 2 26 2
RSK1 26 8
RSK2 55 0
S6K1 30 4
SGK1 94 9
SIK2
8
 1
SIK3 63 3
SmMLCK 69 0
Src
1
 2
SRPK1 108 7
STK33 42 6
SYK
8
 2
TAK1
-2
 11
TAO1 28 0
TBK1
10
 0
TESK1 43 2
TGFBR1 131 26
TIE2 52 4
TLK1 70 5
TrkA
3
 2
TSSK1
5
 1
TTBK1 100 1
TTBK2 107 4
TTK 49 2
ULK1
2
 0
ULK2
10
 0
VEGFR1
4
 1
WNK1 108 1
YES1
5
 1
ZAP70 60 9