Inhibitor | Purvalanol A  

Screen Conc: 0.10µM

Kinase	% Activity Remaining	Standard Deviation
ABL	95	5
AMPK	101	6
ASK1	112	2
Aurora A	125	9
Aurora B	116	9
BRK	133	8
BRSK1	100	0
BRSK2	76	6
BTK	66	7
CAMK1	113	10
CAMKK beta	60	2
CDK2-Cyclin A	10	1
CHK1	103	1
CHK2	90	8
CK1 delta	91	10
CK2	92	0
CLK2	17	4
CSK	97	7
DAPK1	106	7
DYRK1A	79	3
DYRK2	117	3
DYRK3	94	6
EF2K	83	6
EPH-A2	119	14
EPH-A4	122	2
EPH-B1	127	3
EPH-B2	100	1
EPH-B3	100	0
EPH-B4	101	1
ERK1	121	14
ERK2	98	11
ERK8	59	1
FGF-R1	118	6
GCK	83	9
GSK3 beta	109	8
HER4	123	10
HIPK1	114	5
HIPK2	99	11
HIPK3	109	6
IGF-1R	71	7
IKK beta	101	0
IKK epsilon	91	13
IR	106	18
IRAK4	60	5
IRR	73	12
JAK2	95	14
JNK1	104	3
JNK2	89	4
JNK3	108	1
Lck	95	10
LKB1	92	9
MAPKAP-K2	98	15
MAPKAP-K3	119	10
MARK1	106	1
MARK2	96	3
MARK3	101	15
MARK4	118	7
MEKK1	80	5
MELK	72	3
MINK1	104	10
MKK1	115	3
MKK2	108	5
MKK6	94	3
MLK1	51	1
MLK3	65	9
MNK1	92	5
MNK2	98	1
MPSK1	112	9
MSK1	113	11
MST2	77	0
MST4	91	13
NEK2a	95	1
NEK6	107	1
NUAK1	106	0
p38 alpha MAPK	99	3
p38 beta MAPK	105	10
p38 delta MAPK	99	10
p38 gamma MAPK	98	13
PAK2	94	2
PAK4	34	2
PAK5	78	3
PAK6	107	1
PDK1	118	6
PHK	99	0
PIM1	97	4
PIM2	112	12
PIM3	119	12
PKA	107	2
PKB alpha	125	14
PKB beta	105	15
PKC alpha	100	1
PKC gamma	97	1
PKC zeta	105	2
PKD1	118	14
PLK1	94	1
PRAK	118	14
PRK2	81	9
RIPK2	110	5
ROCK 2	101	5
RSK1	98	13
RSK2	97	13
S6K1	106	12
SGK1	89	1
SmMLCK	106	3
Src	19	1
SRPK1	80	5
STK33	99	13
SYK	118	4
TAK1	61	9
TAO1	118	8
TBK1	109	11
TIE2	164	21
TrkA	45	4
TTK	102	5
VEGFR1	81	6
YES1	34	6
ZAP70	131	4

Screen Conc: 1.00µM

Kinase	% Activity Remaining	Standard Deviation
ABL	41	8
AMPK	93	6
ASK1	100	1
Aurora A	100	5
Aurora B	95	9
BRK	111	2
BRSK1	76	1
BRSK2	107	6
BTK	33	3
CAMK1	96	2
CAMKK beta	21	5
CDK2-Cyclin A	3	0
CHK1	90	1
CHK2	64	12
CK1 delta	78	1
CK2	72	11
CLK2	4	1
CSK	89	13
DAPK1	104	12
DYRK1A	24	1
DYRK2	103	1
DYRK3	82	10
EF2K	87	7
EPH-A2	66	7
EPH-A4	45	9
EPH-B1	83	8
EPH-B2	30	2
EPH-B3	63	1
EPH-B4	37	15
ERK1	87	5
ERK2	57	2
ERK8	11	0
FGF-R1	69	5
GCK	40	2
GSK3 beta	71	7
HER4	109	20
HIPK1	85	15
HIPK2	52	2
HIPK3	119	6
IGF-1R	38	11
IKK beta	84	10
IKK epsilon	99	23
IR	53	15
IRAK4	21	0
IRR	34	3
JAK2	73	3
JNK1	90	9
JNK2	88	2
JNK3	92	2
Lck	35	3
LKB1	60	3
MAPKAP-K2	94	14
MAPKAP-K3	116	1
MARK1	90	6
MARK2	89	5
MARK3	73	6
MARK4	78	2
MEKK1	36	7
MELK	57	0
MINK1	80	1
MKK1	93	24
MKK2	108	8
MKK6	101	23
MLK1	7	0
MLK3	11	0
MNK1	94	11
MNK2	112	1
MPSK1	100	2
MSK1	110	9
MST2	28	2
MST4	48	0
NEK2a	94	12
NEK6	90	3
NUAK1	60	2
p38 alpha MAPK	86	10
p38 beta MAPK	109	6
p38 delta MAPK	97	1
p38 gamma MAPK	87	10
PAK2	95	6
PAK4	8	1
PAK5	29	1
PAK6	59	3
PDK1	110	2
PHK	79	1
PIM1	87	9
PIM2	98	0
PIM3	93	13
PKA	105	1
PKB alpha	116	10
PKB beta	91	14
PKC alpha	98	4
PKC gamma	91	4
PKC zeta	98	6
PKD1	121	2
PLK1	108	10
PRAK	65	2
PRK2	70	9
RIPK2	111	3
ROCK 2	101	3
RSK1	47	7
RSK2	59	2
S6K1	110	0
SGK1	76	15
SmMLCK	36	1
Src	2	1
SRPK1	32	0
STK33	62	7
SYK	109	14
TAK1	19	1
TAO1	70	5
TBK1	97	7
TIE2	120	12
TrkA	13	1
TTK	53	3
VEGFR1	70	1
YES1	9	1
ZAP70	119	6